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dc.contributor.authorChartier, Karen G
dc.contributor.authorDick, Danielle M
dc.contributor.authorAlmasy, Laura
dc.contributor.authorChan, Grace
dc.contributor.authorAliev, Fazil
dc.contributor.authorSchuckit, Marc A
dc.contributor.authorScott, Denise M
dc.contributor.authorKramer, John
dc.contributor.authorBucholz, Kathleen K
dc.contributor.authorBierut, Laura J
dc.contributor.authorNurnberger, John
dc.contributor.authorPorjesz, Bernice
dc.contributor.authorHesselbrock, Victor M
dc.date.accessioned2023-01-09T17:53:29Z
dc.date.available2023-01-09T17:53:29Z
dc.identifier.citationChartier KG, Dick DM, Almasy L, Chan G, Aliev F, Schuckit MA, Scott DM, Kramer J, Bucholz KK, Bierut LJ, Nurnberger J Jr, Porjesz B, Hesselbrock VM. Interactions Between Alcohol Metabolism Genes and Religious Involvement in Association With Maximum Drinks and Alcohol Dependence Symptoms. J Stud Alcohol Drugs. 2016 May;77(3):393-404. doi: 10.15288/jsad.2016.77.393. PMID: 27172571; PMCID: PMC4869897.en_US
dc.identifier.eissn1938-4114
dc.identifier.pmid27172571
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8076
dc.description.abstractVariations in the genes encoding alcohol dehydrogenase (ADH) enzymes are associated with both alcohol consumption and dependence in multiple populations. Additionally, some environmental factors have been recognized as modifiers of these relationships. This study examined the modifying effect of religious involvement on relationships between ADH gene variants and alcohol consumption-related phenotypes.
dc.description.abstractSubjects were African American, European American, and Hispanic American adults with lifetime exposure to alcohol (N = 7,716; 53% female) from the Collaborative Study on the Genetics of Alcoholism. Genetic markers included ADH1Brs1229984, ADH1B-rs2066702, ADH1C-rs698, ADH4-rs1042364, and ADH4-rs1800759. Phenotypes were maximum drinks consumed in a 24-hour period and total number of alcohol dependence symptoms according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Religious involvement was defined by self-reported religious services attendance.
dc.description.abstractBoth religious involvement and ADH1B-rs1229984 were negatively associated with the number of maximum drinks consumed and the number of lifetime alcohol dependence symptoms endorsed. The interactions of religious involvement with ADH1B-rs2066702, ADH1C-rs698, and ADH4-rs1042364 were significantly associated with maximum drinks and alcohol dependence symptoms. Risk variants had weaker associations with maximum drinks and alcohol dependence symptoms as a function of increasing religious involvement.
dc.description.abstractThis study provided initial evidence of a modifying effect for religious involvement on relationships between ADH variants and maximum drinks and alcohol dependence symptoms.
dc.language.isoenen_US
dc.relation.urlhttps://www.jsad.com/doi/abs/10.15288/jsad.2016.77.393en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleInteractions Between Alcohol Metabolism Genes and Religious Involvement in Association With Maximum Drinks and Alcohol Dependence Symptoms.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleJournal of studies on alcohol and drugsen_US
dc.source.volume77
dc.source.issue3
dc.source.beginpage393
dc.source.endpage404
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.description.versionAMen_US
refterms.dateFOA2023-01-09T17:53:30Z
html.description.abstractVariations in the genes encoding alcohol dehydrogenase (ADH) enzymes are associated with both alcohol consumption and dependence in multiple populations. Additionally, some environmental factors have been recognized as modifiers of these relationships. This study examined the modifying effect of religious involvement on relationships between ADH gene variants and alcohol consumption-related phenotypes.
html.description.abstractSubjects were African American, European American, and Hispanic American adults with lifetime exposure to alcohol (N = 7,716; 53% female) from the Collaborative Study on the Genetics of Alcoholism. Genetic markers included ADH1Brs1229984, ADH1B-rs2066702, ADH1C-rs698, ADH4-rs1042364, and ADH4-rs1800759. Phenotypes were maximum drinks consumed in a 24-hour period and total number of alcohol dependence symptoms according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Religious involvement was defined by self-reported religious services attendance.
html.description.abstractBoth religious involvement and ADH1B-rs1229984 were negatively associated with the number of maximum drinks consumed and the number of lifetime alcohol dependence symptoms endorsed. The interactions of religious involvement with ADH1B-rs2066702, ADH1C-rs698, and ADH4-rs1042364 were significantly associated with maximum drinks and alcohol dependence symptoms. Risk variants had weaker associations with maximum drinks and alcohol dependence symptoms as a function of increasing religious involvement.
html.description.abstractThis study provided initial evidence of a modifying effect for religious involvement on relationships between ADH variants and maximum drinks and alcohol dependence symptoms.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentHenri Begleiter Neurodynamics Laboratoryen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalJournal of studies on alcohol and drugs


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