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dc.contributor.authorBucholz, Kathleen K
dc.contributor.authorMcCutcheon, Vivia V
dc.contributor.authorAgrawal, Arpana
dc.contributor.authorDick, Danielle M
dc.contributor.authorHesselbrock, Victor M
dc.contributor.authorKramer, John R
dc.contributor.authorKuperman, Samuel
dc.contributor.authorNurnberger, John I
dc.contributor.authorSalvatore, Jessica E
dc.contributor.authorSchuckit, Marc A
dc.contributor.authorBierut, Laura J
dc.contributor.authorForoud, Tatiana M
dc.contributor.authorChan, Grace
dc.contributor.authorHesselbrock, Michie
dc.contributor.authorMeyers, Jacquelyn L
dc.contributor.authorEdenberg, Howard J
dc.contributor.authorPorjesz, Bernice
dc.date.accessioned2023-01-09T17:46:25Z
dc.date.available2023-01-09T17:46:25Z
dc.date.issued2017-01-10
dc.identifier.citationBucholz KK, McCutcheon VV, Agrawal A, Dick DM, Hesselbrock VM, Kramer JR, Kuperman S, Nurnberger JI Jr, Salvatore JE, Schuckit MA, Bierut LJ, Foroud TM, Chan G, Hesselbrock M, Meyers JL, Edenberg HJ, Porjesz B. Comparison of Parent, Peer, Psychiatric, and Cannabis Use Influences Across Stages of Offspring Alcohol Involvement: Evidence from the COGA Prospective Study. Alcohol Clin Exp Res. 2017 Feb;41(2):359-368. doi: 10.1111/acer.13293. Epub 2017 Jan 10. PMID: 28073157; PMCID: PMC5272776.en_US
dc.identifier.eissn1530-0277
dc.identifier.doi10.1111/acer.13293
dc.identifier.pmid28073157
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8074
dc.description.abstractAll stages of development of alcohol use disorder (AUD) have not been equally studied. While initiation of drinking has been given considerable attention, other stages have not been as thoroughly investigated. It is not clear whether the same factors are associated consistently across early and late transitions in AUD involvement. High-risk family samples that are enriched for AUD vulnerability and transitions in AUD development offer an opportunity to examine influences across multiple stages of AUD development.
dc.description.abstractData from adolescents and young adults from high-risk families were used to study 4 transitions in AUD development-time to first drink, first drink to first problem, first drink to first diagnosis, and first problem to first diagnosis. Cox modeling was used to compare associations of parental AUD, parental separation, peer substance use, offspring ever-use of cannabis, trauma exposures, and internalizing and externalizing psychopathology across transitions.
dc.description.abstractHazards of most transitions were elevated for those who had ever used cannabis, those who attributed substance use to their peers, those with externalizing disorders, and those with parents with AUD. Many risk factors were linked to early initiation of alcohol, particularly cannabis use. Internalizing disorders were associated with later stages. Nonassaultive trauma was associated only with early initiation; assaultive trauma was not associated with any transition.
dc.description.abstractIn this large, ethnically diverse sample of high-risk youth, significant influences across transitions were fairly consistent, with externalizing disorders and cannabis ever-use elevating the likelihood of each stage, and peer and parental (and especially maternal AUD) influences linked to initiation and some later stages. Finally, in light of the increasingly permissive legal and social stances toward cannabis in the United States, the marked elevations of all alcohol outcomes observed for cannabis use underscore the importance of studying the underpinnings of this relationship.
dc.language.isoenen_US
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/10.1111/acer.13293en_US
dc.rightsCopyright © 2017 by the Research Society on Alcoholism.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAlcohol Involvementen_US
dc.subjectExternalizing Disordersen_US
dc.subjectHigh-Risk Familiesen_US
dc.subjectInternalizing Disordersen_US
dc.subjectParental Alcohol Use Disorderen_US
dc.titleComparison of Parent, Peer, Psychiatric, and Cannabis Use Influences Across Stages of Offspring Alcohol Involvement: Evidence from the COGA Prospective Study.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleAlcoholism, clinical and experimental researchen_US
dc.source.volume41
dc.source.issue2
dc.source.beginpage359
dc.source.endpage368
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryEngland
dc.description.versionAMen_US
refterms.dateFOA2023-01-09T17:46:26Z
html.description.abstractAll stages of development of alcohol use disorder (AUD) have not been equally studied. While initiation of drinking has been given considerable attention, other stages have not been as thoroughly investigated. It is not clear whether the same factors are associated consistently across early and late transitions in AUD involvement. High-risk family samples that are enriched for AUD vulnerability and transitions in AUD development offer an opportunity to examine influences across multiple stages of AUD development.
html.description.abstractData from adolescents and young adults from high-risk families were used to study 4 transitions in AUD development-time to first drink, first drink to first problem, first drink to first diagnosis, and first problem to first diagnosis. Cox modeling was used to compare associations of parental AUD, parental separation, peer substance use, offspring ever-use of cannabis, trauma exposures, and internalizing and externalizing psychopathology across transitions.
html.description.abstractHazards of most transitions were elevated for those who had ever used cannabis, those who attributed substance use to their peers, those with externalizing disorders, and those with parents with AUD. Many risk factors were linked to early initiation of alcohol, particularly cannabis use. Internalizing disorders were associated with later stages. Nonassaultive trauma was associated only with early initiation; assaultive trauma was not associated with any transition.
html.description.abstractIn this large, ethnically diverse sample of high-risk youth, significant influences across transitions were fairly consistent, with externalizing disorders and cannabis ever-use elevating the likelihood of each stage, and peer and parental (and especially maternal AUD) influences linked to initiation and some later stages. Finally, in light of the increasingly permissive legal and social stances toward cannabis in the United States, the marked elevations of all alcohol outcomes observed for cannabis use underscore the importance of studying the underpinnings of this relationship.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentHenri Begleiter Neurodynamics Laboratoryen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalAlcoholism, clinical and experimental research


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Copyright © 2017 by the Research Society on Alcoholism.
Except where otherwise noted, this item's license is described as Copyright © 2017 by the Research Society on Alcoholism.