Comparison of Parent, Peer, Psychiatric, and Cannabis Use Influences Across Stages of Offspring Alcohol Involvement: Evidence from the COGA Prospective Study.
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AuthorBucholz, Kathleen K
McCutcheon, Vivia V
Dick, Danielle M
Hesselbrock, Victor M
Kramer, John R
Nurnberger, John I
Salvatore, Jessica E
Schuckit, Marc A
Bierut, Laura J
Foroud, Tatiana M
Meyers, Jacquelyn L
Edenberg, Howard J
Parental Alcohol Use Disorder
Journal titleAlcoholism, clinical and experimental research
Publication Begin page359
Publication End page368
MetadataShow full item record
AbstractAll stages of development of alcohol use disorder (AUD) have not been equally studied. While initiation of drinking has been given considerable attention, other stages have not been as thoroughly investigated. It is not clear whether the same factors are associated consistently across early and late transitions in AUD involvement. High-risk family samples that are enriched for AUD vulnerability and transitions in AUD development offer an opportunity to examine influences across multiple stages of AUD development.
Data from adolescents and young adults from high-risk families were used to study 4 transitions in AUD development-time to first drink, first drink to first problem, first drink to first diagnosis, and first problem to first diagnosis. Cox modeling was used to compare associations of parental AUD, parental separation, peer substance use, offspring ever-use of cannabis, trauma exposures, and internalizing and externalizing psychopathology across transitions.
Hazards of most transitions were elevated for those who had ever used cannabis, those who attributed substance use to their peers, those with externalizing disorders, and those with parents with AUD. Many risk factors were linked to early initiation of alcohol, particularly cannabis use. Internalizing disorders were associated with later stages. Nonassaultive trauma was associated only with early initiation; assaultive trauma was not associated with any transition.
In this large, ethnically diverse sample of high-risk youth, significant influences across transitions were fairly consistent, with externalizing disorders and cannabis ever-use elevating the likelihood of each stage, and peer and parental (and especially maternal AUD) influences linked to initiation and some later stages. Finally, in light of the increasingly permissive legal and social stances toward cannabis in the United States, the marked elevations of all alcohol outcomes observed for cannabis use underscore the importance of studying the underpinnings of this relationship.
CitationBucholz KK, McCutcheon VV, Agrawal A, Dick DM, Hesselbrock VM, Kramer JR, Kuperman S, Nurnberger JI Jr, Salvatore JE, Schuckit MA, Bierut LJ, Foroud TM, Chan G, Hesselbrock M, Meyers JL, Edenberg HJ, Porjesz B. Comparison of Parent, Peer, Psychiatric, and Cannabis Use Influences Across Stages of Offspring Alcohol Involvement: Evidence from the COGA Prospective Study. Alcohol Clin Exp Res. 2017 Feb;41(2):359-368. doi: 10.1111/acer.13293. Epub 2017 Jan 10. PMID: 28073157; PMCID: PMC5272776.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Copyright © 2017 by the Research Society on Alcoholism.
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