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dc.contributor.authorMeyers, Jacquelyn L
dc.contributor.authorZhang, Jian
dc.contributor.authorManz, Niklas
dc.contributor.authorRangaswamy, Madhavi
dc.contributor.authorKamarajan, Chella
dc.contributor.authorWetherill, Leah
dc.contributor.authorChorlian, David B
dc.contributor.authorKang, Sun J
dc.contributor.authorBauer, Lance
dc.contributor.authorHesselbrock, Victor
dc.contributor.authorKramer, John
dc.contributor.authorKuperman, Samuel
dc.contributor.authorNurnberger, John I
dc.contributor.authorTischfield, Jay
dc.contributor.authorWang, Jen Chyong
dc.contributor.authorEdenberg, Howard J
dc.contributor.authorGoate, Alison
dc.contributor.authorForoud, Tatiana
dc.contributor.authorPorjesz, Bernice
dc.date.accessioned2023-01-09T17:34:00Z
dc.date.available2023-01-09T17:34:00Z
dc.date.issued2016-12-28
dc.identifier.citationMeyers JL, Zhang J, Manz N, Rangaswamy M, Kamarajan C, Wetherill L, Chorlian DB, Kang SJ, Bauer L, Hesselbrock V, Kramer J, Kuperman S, Nurnberger JI Jr, Tischfield J, Wang JC, Edenberg HJ, Goate A, Foroud T, Porjesz B. A genome wide association study of fast beta EEG in families of European ancestry. Int J Psychophysiol. 2017 May;115:74-85. doi: 10.1016/j.ijpsycho.2016.12.008. Epub 2016 Dec 28. PMID: 28040410; PMCID: PMC5426060.en_US
dc.identifier.eissn1872-7697
dc.identifier.doi10.1016/j.ijpsycho.2016.12.008
dc.identifier.pmid28040410
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8071
dc.description.abstractDifferences in fast beta (20-28Hz) electroencephalogram (EEG) oscillatory activity distinguish some individuals with psychiatric and substance use disorders, suggesting that it may be a useful endophenotype for studying the genetics of disorders characterized by neural hyper-excitability. Despite the high heritability estimates provided by twin and family studies, there have been relatively few genetic studies of beta EEG, and to date only one genetic association finding has replicated (i.e., GABRA2).
dc.description.abstractIn a sample of 1564 individuals from 117 families of European Ancestry (EA) drawn from the Collaborative Study on the Genetics of Alcoholism (COGA), we performed a Genome-Wide Association Study (GWAS) on resting-state fronto-central fast beta EEG power, adjusting regression models for family relatedness, age, sex, and ancestry. To further characterize genetic findings, we examined the functional and behavioral significance of GWAS findings.
dc.description.abstractThree intronic variants located within DSE (dermatan sulfate epimerase) on 6q22 were associated with fast beta EEG at a genome wide significant level (p<5×10). The most significant SNP was rs2252790 (p<2.6×10; MAF=0.36; β=0.135). rs2252790 is an eQTL for ROS1 expressed most robustly in the temporal cortex (p=1.2×10) and for DSE/TSPYL4 expressed most robustly in the hippocampus (p=7.3×10; β=0.29). Previous studies have indicated that DSE is involved in a network of genes integral to membrane organization; gene-based tests indicated that several variants within this network (i.e., DSE, ZEB2, RND3, MCTP1, and CTBP2) were also associated with beta EEG (empirical p<0.05), and of these genes, ZEB2 and CTBP2 were associated with DSM-V Alcohol Use Disorder (AUD; empirical p<0.05).'
dc.description.abstractIn this sample of EA families enriched for AUDs, fast beta EEG is associated with variants within DSE on 6q22; the most significant SNP influences the mRNA expression of DSE and ROS1 in hippocampus and temporal cortex, brain regions important for beta EEG activity. Gene-based tests suggest evidence of association with related genes, ZEB2, RND3, MCTP1, CTBP2, and beta EEG. Converging data from GWAS, gene expression, and gene-networks presented in this study provide support for the role of genetic variants within DSE and related genes in neural hyperexcitability, and has highlighted two potential candidate genes for AUD and/or related neurological conditions: ZEB2 and CTBP2. However, results must be replicated in large, independent samples.
dc.language.isoenen_US
dc.relation.urlhttps://www.sciencedirect.com/science/article/abs/pii/S0167876016308625en_US
dc.rightsCopyright © 2016 Elsevier B.V. All rights reserved.
dc.rightsAn error occurred on the license name.*
dc.rights.uriAn error occurred getting the license - uri.*
dc.subjectElectrophysiologyen_US
dc.subjectEndophenotypeen_US
dc.subjectGenome-Wide Association Study (GWAS)en_US
dc.subjectResting EEGen_US
dc.titleA genome wide association study of fast beta EEG in families of European ancestry.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleInternational journal of psychophysiology : official journal of the International Organization of Psychophysiologyen_US
dc.source.volume115
dc.source.beginpage74
dc.source.endpage85
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryNetherlands
dc.description.versionAMen_US
refterms.dateFOA2023-01-09T17:34:00Z
html.description.abstractDifferences in fast beta (20-28Hz) electroencephalogram (EEG) oscillatory activity distinguish some individuals with psychiatric and substance use disorders, suggesting that it may be a useful endophenotype for studying the genetics of disorders characterized by neural hyper-excitability. Despite the high heritability estimates provided by twin and family studies, there have been relatively few genetic studies of beta EEG, and to date only one genetic association finding has replicated (i.e., GABRA2).
html.description.abstractIn a sample of 1564 individuals from 117 families of European Ancestry (EA) drawn from the Collaborative Study on the Genetics of Alcoholism (COGA), we performed a Genome-Wide Association Study (GWAS) on resting-state fronto-central fast beta EEG power, adjusting regression models for family relatedness, age, sex, and ancestry. To further characterize genetic findings, we examined the functional and behavioral significance of GWAS findings.
html.description.abstractThree intronic variants located within DSE (dermatan sulfate epimerase) on 6q22 were associated with fast beta EEG at a genome wide significant level (p<5×10). The most significant SNP was rs2252790 (p<2.6×10; MAF=0.36; β=0.135). rs2252790 is an eQTL for ROS1 expressed most robustly in the temporal cortex (p=1.2×10) and for DSE/TSPYL4 expressed most robustly in the hippocampus (p=7.3×10; β=0.29). Previous studies have indicated that DSE is involved in a network of genes integral to membrane organization; gene-based tests indicated that several variants within this network (i.e., DSE, ZEB2, RND3, MCTP1, and CTBP2) were also associated with beta EEG (empirical p<0.05), and of these genes, ZEB2 and CTBP2 were associated with DSM-V Alcohol Use Disorder (AUD; empirical p<0.05).'
html.description.abstractIn this sample of EA families enriched for AUDs, fast beta EEG is associated with variants within DSE on 6q22; the most significant SNP influences the mRNA expression of DSE and ROS1 in hippocampus and temporal cortex, brain regions important for beta EEG activity. Gene-based tests suggest evidence of association with related genes, ZEB2, RND3, MCTP1, CTBP2, and beta EEG. Converging data from GWAS, gene expression, and gene-networks presented in this study provide support for the role of genetic variants within DSE and related genes in neural hyperexcitability, and has highlighted two potential candidate genes for AUD and/or related neurological conditions: ZEB2 and CTBP2. However, results must be replicated in large, independent samples.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentHenri Begleiter Neurodynamics Laboratoryen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalInternational journal of psychophysiology : official journal of the International Organization of Psychophysiology


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