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dc.contributor.authorKamarajan, Chella
dc.contributor.authorPandey, Ashwini K
dc.contributor.authorChorlian, David B
dc.contributor.authorManz, Niklas
dc.contributor.authorStimus, Arthur T
dc.contributor.authorEdenberg, Howard J
dc.contributor.authorWetherill, Leah
dc.contributor.authorSchuckit, Marc
dc.contributor.authorWang, Jen-Chyong
dc.contributor.authorKuperman, Samuel
dc.contributor.authorKramer, John
dc.contributor.authorTischfield, Jay A
dc.contributor.authorPorjesz, Bernice
dc.date.accessioned2023-01-09T17:31:06Z
dc.date.available2023-01-09T17:31:06Z
dc.date.issued2016-12-16
dc.identifier.citationKamarajan C, Pandey AK, Chorlian DB, Manz N, Stimus AT, Edenberg HJ, Wetherill L, Schuckit M, Wang JC, Kuperman S, Kramer J, Tischfield JA, Porjesz B. A KCNJ6 gene polymorphism modulates theta oscillations during reward processing. Int J Psychophysiol. 2017 May;115:13-23. doi: 10.1016/j.ijpsycho.2016.12.007. Epub 2016 Dec 16. PMID: 27993610; PMCID: PMC5392377.en_US
dc.identifier.eissn1872-7697
dc.identifier.doi10.1016/j.ijpsycho.2016.12.007
dc.identifier.pmid27993610
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8070
dc.description.abstractEvent related oscillations (EROs) are heritable measures of neurocognitive function that have served as useful phenotype in genetic research. A recent family genome-wide association study (GWAS) by the Collaborative Study on the Genetics of Alcoholism (COGA) found that theta EROs during visual target detection were associated at genome-wide levels with several single nucleotide polymorphisms (SNPs), including a synonymous SNP, rs702859, in the KCNJ6 gene that encodes GIRK2, a G-protein inward rectifying potassium channel that regulates excitability of neuronal networks. The present study examined the effect of the KCNJ6 SNP (rs702859), previously associated with theta ERO to targets in a visual oddball task, on theta EROs during reward processing in a monetary gambling task. The participants were 1601 adolescent and young adult offspring within the age-range of 17-25years (800 males and 801 females) from high-dense alcoholism families as well as control families of the COGA prospective study. Theta ERO power (3.5-7.5Hz, 200-500ms post-stimulus) was compared across genotype groups. ERO theta power at central and parietal regions increased as a function of the minor allele (A) dose in the genotype (AA>AG>GG) in both loss and gain conditions. These findings indicate that variations in the KCNJ6 SNP influence magnitude of theta oscillations at posterior loci during the evaluation of loss and gain, reflecting a genetic influence on neuronal circuits involved in reward-processing. Increased theta power as a function of minor allele dose suggests more efficient cognitive processing in those carrying the minor allele of the KCNJ6 SNPs. Future studies are needed to determine the implications of these genetic effects on posterior theta EROs as possible "protective" factors, or as indices of delays in brain maturation (i.e., lack of frontalization).
dc.language.isoenen_US
dc.relation.urlhttps://www.sciencedirect.com/science/article/abs/pii/S0167876016308613en_US
dc.rightsCopyright © 2016 Elsevier B.V. All rights reserved.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAlcoholismen_US
dc.subjectCOGAen_US
dc.subjectEvent-related oscillations (EROs)en_US
dc.subjectGIRK2en_US
dc.subjectKCNJ6en_US
dc.subjectMonetary gambling tasken_US
dc.subjectReward processingen_US
dc.subjectTheta poweren_US
dc.titleA KCNJ6 gene polymorphism modulates theta oscillations during reward processing.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleInternational journal of psychophysiology : official journal of the International Organization of Psychophysiologyen_US
dc.source.volume115
dc.source.beginpage13
dc.source.endpage23
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryNetherlands
dc.description.versionAMen_US
refterms.dateFOA2023-01-09T17:31:07Z
html.description.abstractEvent related oscillations (EROs) are heritable measures of neurocognitive function that have served as useful phenotype in genetic research. A recent family genome-wide association study (GWAS) by the Collaborative Study on the Genetics of Alcoholism (COGA) found that theta EROs during visual target detection were associated at genome-wide levels with several single nucleotide polymorphisms (SNPs), including a synonymous SNP, rs702859, in the KCNJ6 gene that encodes GIRK2, a G-protein inward rectifying potassium channel that regulates excitability of neuronal networks. The present study examined the effect of the KCNJ6 SNP (rs702859), previously associated with theta ERO to targets in a visual oddball task, on theta EROs during reward processing in a monetary gambling task. The participants were 1601 adolescent and young adult offspring within the age-range of 17-25years (800 males and 801 females) from high-dense alcoholism families as well as control families of the COGA prospective study. Theta ERO power (3.5-7.5Hz, 200-500ms post-stimulus) was compared across genotype groups. ERO theta power at central and parietal regions increased as a function of the minor allele (A) dose in the genotype (AA>AG>GG) in both loss and gain conditions. These findings indicate that variations in the KCNJ6 SNP influence magnitude of theta oscillations at posterior loci during the evaluation of loss and gain, reflecting a genetic influence on neuronal circuits involved in reward-processing. Increased theta power as a function of minor allele dose suggests more efficient cognitive processing in those carrying the minor allele of the KCNJ6 SNPs. Future studies are needed to determine the implications of these genetic effects on posterior theta EROs as possible "protective" factors, or as indices of delays in brain maturation (i.e., lack of frontalization).
dc.description.institutionSUNY Downstateen_US
dc.description.departmentHenri Begleiter Neurodynamics Laboratoryen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalInternational journal of psychophysiology : official journal of the International Organization of Psychophysiology


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Copyright © 2016 Elsevier B.V. All rights reserved.
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