• Login
    View Item 
    •   Home
    • University Colleges
    • SUNY Brockport
    • Theses
    • Brockport Senior Honors Theses
    • View Item
    •   Home
    • University Colleges
    • SUNY Brockport
    • Theses
    • Brockport Senior Honors Theses
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of SUNY Open Access RepositoryCommunitiesPublication DateAuthorsTitlesSubjectsDepartmentThis CollectionPublication DateAuthorsTitlesSubjectsDepartmentAuthor ProfilesView

    My Account

    LoginRegister

    Campus Communities in SOAR

    Alfred State CollegeBrockportBroomeCantonDownstateDutchessEmpireFarmingdaleFinger LakesFredoniaMaritimeNew PaltzNiagaraOld WestburyOneontaOnondagaOptometryOswegoPlattsburghPurchase CollegePolytechnic InstituteSUNY Office of Workforce Development and Upward MobilitySUNY PressUpstate Medical

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    EFFECT OF ARGININE METHYLATION ON THE ENZYMATIC ACTIVITY AND FUNCTION OF TbLpn IN TRYPANOSOMA BRUCEI

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    case_z_biology_2020may13.pdf
    Size:
    501.3Kb
    Format:
    PDF
    Download
    Average rating
     
       votes
    Cast your vote
    You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
    Star rating
     
    Your vote was cast
    Thank you for your feedback
    Author
    Zachary M.F Case, Zachary M.F
    Keyword
    Trypanosoma brucei
    Human African trypanosomiasis
    African Sleeping Sickness
    Readers/Advisors
    Pelletier, Michel
    Date Published
    2020-05
    
    Metadata
    Show full item record
    URI
    http://hdl.handle.net/20.500.12648/7997
    Abstract
    Trypanosoma brucei is a protozoan parasite which causes Human African trypanosomiasis (HAT). Trypanosoma brucei is vector borne carrier by the tsetse fly of Sub-Saharan Africa. If left untreated, Human African trypanosomiasis is almost always fatal and represents a very serious health risk. Another version of the disease known as Animal African trypanosomiasis (AAT) also exist and threatens the livestock of farmers. There are two stage of the disease, the first blood steam phase and the second central nervous system phase. In the second phase, T.brucei is able to penetrate the blood brain barrier and cause very pronounced disturbances. This phase is where the disease gets its less formal name, "African Sleeping Sickness" due to the sleep disturbances and neurological symptoms prevalent in the second phase. Treatment options and outlooks are better in the first phase and get significantly worse in the second phase. Many of the treatments available are incredibly toxic, have very pronounced side effects, and often involve painful injections. As a result, a more effective means of treating HAT is necessary. The research in this paper seeks to determine the role of protein arginine methylation of specific arginine residues in TbLpn expression and subcellular localization. TbLpn is a lipin protein found in T.brucei that is homologous to human and yeast lipins. TbLpn is likely involved in membrane biosynthesis and is regulated post transcriptionally by protein arginine methylation. Utilizing site directed mutagenesis, specific arginine residues on a wild type plew TbLpn plasmid were mutated into lysine residues. These specifically changed arginine residues will then be used in T.brucei in order to observe the effects on protein interaction and sub cellular localization.
    Collections
    Brockport Senior Honors Theses

    entitlement

     

    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.