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dc.contributor.authorKapoor, Manav
dc.contributor.authorWang, Jen-Chyong
dc.contributor.authorFarris, Sean P
dc.contributor.authorLiu, Yunlong
dc.contributor.authorMcClintick, Jeanette
dc.contributor.authorGupta, Ishaan
dc.contributor.authorMeyers, Jacquelyn L
dc.contributor.authorBertelsen, Sarah
dc.contributor.authorChao, Michael
dc.contributor.authorNurnberger, John
dc.contributor.authorTischfield, Jay
dc.contributor.authorHarari, Oscar
dc.contributor.authorZeran, Li
dc.contributor.authorHesselbrock, Victor
dc.contributor.authorBauer, Lance
dc.contributor.authorRaj, Towfique
dc.contributor.authorPorjesz, Bernice
dc.contributor.authorAgrawal, Arpana
dc.contributor.authorForoud, Tatiana
dc.contributor.authorEdenberg, Howard J
dc.contributor.authorMayfield, R Dayne
dc.contributor.authorGoate, Alison
dc.date.accessioned2022-12-09T17:19:54Z
dc.date.available2022-12-09T17:19:54Z
dc.date.issued2019-02-14
dc.identifier.citationKapoor M, Wang JC, Farris SP, Liu Y, McClintick J, Gupta I, Meyers JL, Bertelsen S, Chao M, Nurnberger J, Tischfield J, Harari O, Zeran L, Hesselbrock V, Bauer L, Raj T, Porjesz B, Agrawal A, Foroud T, Edenberg HJ, Mayfield RD, Goate A. Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism. Transl Psychiatry. 2019 Feb 14;9(1):89. doi: 10.1038/s41398-019-0384-y. PMID: 30765688; PMCID: PMC6376002.en_US
dc.identifier.eissn2158-3188
dc.identifier.doi10.1038/s41398-019-0384-y
dc.identifier.pmid30765688
dc.identifier.urihttp://hdl.handle.net/20.500.12648/7935
dc.description.abstractAlcohol exposure triggers changes in gene expression and biological pathways in human brain. We explored alterations in gene expression in the Pre-Frontal Cortex (PFC) of 65 alcoholics and 73 controls of European descent, and identified 129 genes that showed altered expression (FDR < 0.05) in subjects with alcohol dependence. Differentially expressed genes were enriched for pathways related to interferon signaling and Growth Arrest and DNA Damage-inducible 45 (GADD45) signaling. A coexpression module (thistle2) identified by weighted gene co-expression network analysis (WGCNA) was significantly correlated with alcohol dependence, alcohol consumption, and AUDIT scores. Genes in the thistle2 module were enriched with genes related to calcium signaling pathways and showed significant downregulation of these pathways, as well as enrichment for biological processes related to nicotine response and opioid signaling. A second module (brown4) showed significant upregulation of pathways related to immune signaling. Expression quantitative trait loci (eQTLs) for genes in the brown4 module were also enriched for genetic associations with alcohol dependence and alcohol consumption in large genome-wide studies included in the Psychiatric Genetic Consortium and the UK Biobank's alcohol consumption dataset. By leveraging multi-omics data, this transcriptome analysis has identified genes and biological pathways that could provide insight for identifying therapeutic targets for alcohol dependence.en_US
dc.language.isoenen_US
dc.relation.urlhttps://www.nature.com/articles/s41398-019-0384-yen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleAnalysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleTranslational psychiatryen_US
dc.source.volume9
dc.source.issue1
dc.source.beginpage89
dc.source.endpage
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.description.versionVoRen_US
refterms.dateFOA2022-12-09T17:19:54Z
dc.description.institutionSUNY Downstateen_US
dc.description.departmentHenri Begleiter Neurodynamics Laboratoryen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalTranslational psychiatry


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