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dc.contributor.authorMeyers, Jacquelyn L
dc.contributor.authorSalvatore, Jessica E
dc.contributor.authorAliev, Fazil
dc.contributor.authorJohnson, Emma C
dc.contributor.authorMcCutcheon, Vivia V
dc.contributor.authorSu, Jinni
dc.contributor.authorKuo, Sally I-Chun
dc.contributor.authorLai, Dongbing
dc.contributor.authorWetherill, Leah
dc.contributor.authorWang, Jen C
dc.contributor.authorChan, Grace
dc.contributor.authorHesselbrock, Victor
dc.contributor.authorForoud, Tatiana
dc.contributor.authorBucholz, Kathleen K
dc.contributor.authorEdenberg, Howard J
dc.contributor.authorDick, Danielle M
dc.contributor.authorPorjesz, Bernice
dc.contributor.authorAgrawal, Arpana
dc.date.accessioned2022-12-09T17:01:36Z
dc.date.available2022-12-09T17:01:36Z
dc.date.issued2019-10-21
dc.identifier.citationMeyers JL, Salvatore JE, Aliev F, Johnson EC, McCutcheon VV, Su J, Kuo SI, Lai D, Wetherill L, Wang JC, Chan G, Hesselbrock V, Foroud T, Bucholz KK, Edenberg HJ, Dick DM, Porjesz B, Agrawal A. Psychosocial moderation of polygenic risk for cannabis involvement: the role of trauma exposure and frequency of religious service attendance. Transl Psychiatry. 2019 Oct 21;9(1):269. doi: 10.1038/s41398-019-0598-z. PMID: 31636251; PMCID: PMC6803671.en_US
dc.identifier.eissn2158-3188
dc.identifier.doi10.1038/s41398-019-0598-z
dc.identifier.pmid31636251
dc.identifier.urihttp://hdl.handle.net/20.500.12648/7931
dc.description.abstractCannabis use and disorders (CUD) are influenced by multiple genetic variants of small effect and by the psychosocial environment. However, this information has not been effectively incorporated into studies of gene-environment interaction (GxE). Polygenic risk scores (PRS) that aggregate the effects of genetic variants can aid in identifying the links between genetic risk and psychosocial factors. Using data from the Pasman et al. GWAS of cannabis use (meta-analysis of data from the International Cannabis Consortium and UK Biobank), we constructed PRS in the Collaborative Study on the Genetics of Alcoholism (COGA) participants of European (N: 7591) and African (N: 3359) ancestry. The primary analyses included only individuals of European ancestry, reflecting the ancestral composition of the discovery GWAS from which the PRS was derived. Secondary analyses included the African ancestry sample. Associations of PRS with cannabis use and DSM-5 CUD symptom count (CUDsx) and interactions with trauma exposure and frequency of religious service attendance were examined. Models were adjusted for sex, birth cohort, genotype array, and ancestry. Robustness models were adjusted for cross-term interactions. Higher PRS were associated with a greater likelihood of cannabis use and with CUDsx among participants of European ancestry (p < 0.05 and p < 0.1 thresholds, respectively). PRS only influenced cannabis use among those exposed to trauma (R: 0.011 among the trauma exposed vs. R: 0.002 in unexposed). PRS less consistently influenced cannabis use among those who attend religious services less frequently; PRS × religious service attendance effects were attenuated when cross-term interactions with ancestry and sex were included in the model. Polygenic liability to cannabis use was related to cannabis use and, less robustly, progression to symptoms of CUD. This study provides the first evidence of PRS × trauma for cannabis use and demonstrates that ignoring important aspects of the psychosocial environment may mask genetic influences on polygenic traits.en_US
dc.language.isoenen_US
dc.relation.urlhttps://www.nature.com/articles/s41398-019-0598-zen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titlePsychosocial moderation of polygenic risk for cannabis involvement: the role of trauma exposure and frequency of religious service attendance.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleTranslational psychiatryen_US
dc.source.volume9
dc.source.issue1
dc.source.beginpage269
dc.source.endpage
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.description.versionVoRen_US
refterms.dateFOA2022-12-09T17:01:37Z
dc.description.institutionSUNY Downstateen_US
dc.description.departmentHenri Begleiter Neurodynamics Laboratoryen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalTranslational psychiatry


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