Association of Polygenic Liability for Alcohol Dependence and EEG Connectivity in Adolescence and Young Adulthood.
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Author
Meyers, Jacquelyn LChorlian, David B
Johnson, Emma C
Pandey, Ashwini K
Kamarajan, Chella
Salvatore, Jessica E
Aliev, Fazil
Subbie-Saenz de Viteri, Stacey
Zhang, Jian
Chao, Michael
Kapoor, Manav
Hesselbrock, Victor
Kramer, John
Kuperman, Samuel
Nurnberger, John
Tischfield, Jay
Goate, Alison
Foroud, Tatiana
Dick, Danielle M
Edenberg, Howard J
Agrawal, Arpana
Porjesz, Bernice
Journal title
Brain sciencesDate Published
2019-10-17Publication Volume
9Publication Issue
10
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Show full item recordAbstract
Differences in the connectivity of large-scale functional brain networks among individuals with alcohol use disorders (AUD), as well as those at risk for AUD, point to dysfunctional neural communication and related cognitive impairments. In this study, we examined how polygenic risk scores (PRS), derived from a recent GWAS of DSM-IV Alcohol Dependence (AD) conducted by the Psychiatric Genomics Consortium, relate to longitudinal measures of interhemispheric and intrahemispheric EEG connectivity (alpha, theta, and beta frequencies) in adolescent and young adult offspring from the Collaborative Study on the Genetics of Alcoholism (COGA) assessed between ages 12 and 31. Our findings indicate that AD PRS (-threshold < 0.001) was associated with increased fronto-central, tempo-parietal, centro-parietal, and parietal-occipital interhemispheric theta and alpha connectivity in males only from ages 18-31 (beta coefficients ranged from 0.02-0.06, -values ranged from 10-10), but not in females. Individuals with higher AD PRS also demonstrated more performance deficits on neuropsychological tasks (Tower of London task, visual span test) as well as increased risk for lifetime DSM-5 alcohol and opioid use disorders. We conclude that measures of neural connectivity, together with neurocognitive performance and substance use behavior, can be used to further understanding of how genetic risk variants from large GWAS of AUD may influence brain function. In addition, these data indicate the importance of examining sex and developmental effects, which otherwise may be masked. Understanding of neural mechanisms linking genetic variants emerging from GWAS to risk for AUD throughout development may help to identify specific points when neurocognitive prevention and intervention efforts may be most effective.Citation
Meyers JL, Chorlian DB, Johnson EC, Pandey AK, Kamarajan C, Salvatore JE, Aliev F, Subbie-Saenz de Viteri S, Zhang J, Chao M, Kapoor M, Hesselbrock V, Kramer J, Kuperman S, Nurnberger J, Tischfield J, Goate A, Foroud T, Dick DM, Edenberg HJ, Agrawal A, Porjesz B. Association of Polygenic Liability for Alcohol Dependence and EEG Connectivity in Adolescence and Young Adulthood. Brain Sci. 2019 Oct 17;9(10):280. doi: 10.3390/brainsci9100280. PMID: 31627376; PMCID: PMC6826735.DOI
10.3390/brainsci9100280ae974a485f413a2113503eed53cd6c53
10.3390/brainsci9100280
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International
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