Associations between Suicidal Thoughts and Behaviors and Genetic Liability for Cognitive Performance, Depression, and Risk-Taking in a High-Risk Sample.
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Author
Johnson, Emma CAliev, Fazil
Meyers, Jacquelyn L
Salvatore, Jessica E
Tillman, Rebecca
Chang, Yoonhoo
Docherty, Anna R
Bogdan, Ryan
Acion, Laura
Chan, Grace
Chorlian, David B
Kamarajan, Chella
Kuperman, Samuel
Pandey, Ashwini
Plawecki, Martin H
Schuckit, Marc
Tischfield, Jay
Edenberg, Howard J
Bucholz, Kathleen K
Nurnberger, John I
Porjesz, Bernice
Hesselbrock, Victor
Dick, Danielle M
Kramer, John R
Agrawal, Arpana
Journal title
Complex psychiatryDate Published
2021-05-18Publication Volume
7Publication Issue
1-2Publication Begin page
34Publication End page
44
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Show full item recordAbstract
Background: Suicidal thoughts and behaviors (STBs) and nonsuicidal self-injury (NSSI) behaviors are moderately heritable and may reflect an underlying predisposition to depression, impulsivity, and cognitive vulnerabilities to varying degrees. Objectives: We aimed to estimate the degrees of association between genetic liability to depression, impulsivity, and cognitive performance and STBs and NSSI in a high-risk sample. Methods: We used data on 7,482 individuals of European ancestry and 3,359 individuals of African ancestry from the Collaborative Study on the Genetics of Alcoholism to examine the links between polygenic scores (PGSs) for depression, impulsivity/risk-taking, and cognitive performance with 3 self-reported indices of STBs (suicidal ideation, persistent suicidal ideation defined as ideation occurring on at least 7 consecutive days, and suicide attempt) and with NSSI. Results: The PGS for depression was significantly associated with all 4 primary self-harm measures, explaining 0.6-2.5% of the variance. The PGS for risk-taking behaviors was also associated with all 4 self-harm behaviors in baseline models, but was no longer associated after controlling for a lifetime measure of DSM-IV alcohol dependence and abuse symptom counts. Polygenic predisposition for cognitive performance was negatively associated with suicide attempts (q = 3.8e-4) but was not significantly associated with suicidal ideation nor NSSI. We did not find any significant associations in the African ancestry subset, likely due to smaller sample sizes. Conclusions: Our results encourage the study of STB as transdiagnostic outcomes that show genetic overlap with a range of risk factors.Citation
Johnson EC, Aliev F, Meyers JL, Salvatore JE, Tillman R, Chang Y, Docherty AR, Bogdan R, Acion L, Chan G, Chorlian DB, Kamarajan C, Kuperman S, Pandey A, Plawecki MH, Schuckit M, Tischfield J, Edenberg HJ, Bucholz KK, Nurnberger JI, Porjesz B, Hesselbrock V, Dick DM, Kramer JR, Agrawal A. Associations between Suicidal Thoughts and Behaviors and Genetic Liability for Cognitive Performance, Depression, and Risk-Taking in a High-Risk Sample. Complex Psychiatry. 2021 Aug;7(1-2):34-44. doi: 10.1159/000517169. Epub 2021 May 18. PMID: 35592092; PMCID: PMC8443930.DOI
10.1159/000517169ae974a485f413a2113503eed53cd6c53
10.1159/000517169
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Except where otherwise noted, this item's license is described as Copyright © 2021 by S. Karger AG, Basel.