The potential utility of integrated reflectance confocal microscopy-optical coherence tomography for guiding triage and therapy of basal cell carcinomas.
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Author
Iftimia, NicusorSahu, Aditi
Cordova, Miguel
Maguluri, Gopi
Gill, Melissa
Alessi-Fox, Christi
Gonzalez, Salvador
Navarrete-Dechent, Cristian
Marghoob, Ashfaq
Chen, Chih-Shan J
Rajadhyaksha, Milind
Keyword
basal cell carcinomasinvasive non-surgical treatments
optical coherence tomography
reflectance confocal microscopy
Journal title
Journal of CancerDate Published
2020-08-18Publication Volume
11Publication Issue
20Publication Begin page
6019Publication End page
6024
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Show full item recordAbstract
The increasing rate of incidence and prevalence of basal cell carcinomas (BCCs) worldwide, combined with the morbidity associated with conventional surgical treatment has led to the development and use of alternative minimally invasive non-surgical treatments. Biopsy and pathology are used to guide BCC diagnosis and assess margins and subtypes, which then guide the decision and choice of surgical or non-surgical treatment. However, alternatively, a noninvasive optical approach based on combined reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) imaging may be used. Optical imaging may be used to guide diagnosis and margin assessment at the bedside, and potentially facilitate non-surgical management, along with long-term monitoring of treatment response. Noninvasive imaging may also complement minimally invasive treatments and help further reduce morbidity. In this paper, we highlight the current state of an integrated RCM/OCT imaging approach for diagnosis and triage of BCCs, as well as for assessing margins, which therefore may be ultimately used for guiding therapy.Citation
Iftimia N, Sahu A, Cordova M, Maguluri G, Gill M, Alessi-Fox C, Gonzalez S, Navarrete-Dechent C, Marghoob A, Chen CJ, Rajadhyaksha M. The potential utility of integrated reflectance confocal microscopy-optical coherence tomography for guiding triage and therapy of basal cell carcinomas. J Cancer. 2020 Aug 18;11(20):6019-6024. doi: 10.7150/jca.47026. PMID: 32922542; PMCID: PMC7477415.DOI
10.7150/jca.47026ae974a485f413a2113503eed53cd6c53
10.7150/jca.47026
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