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dc.contributor.authorGill, Melissa
dc.contributor.authorSahu, Aditi
dc.contributor.authorAlessi-Fox, Christi
dc.contributor.authorCordova, Miguel
dc.contributor.authorGonzalez, Salvador
dc.contributor.authorIftimia, Nicusor
dc.contributor.authorAleissa, Saud
dc.contributor.authorNavarrete-Dechent, Cristian
dc.contributor.authorDusza, Stephen
dc.contributor.authorRossi, Anthony
dc.contributor.authorMarghoob, Ashfaq A
dc.contributor.authorRajadhyaksha, Milind
dc.contributor.authorChen, Chih-Shan J
dc.date.accessioned2022-11-02T16:43:29Z
dc.date.available2022-11-02T16:43:29Z
dc.date.issued2020-10-12
dc.identifier.citationGill M, Sahu A, Alessi-Fox C, Cordova M, Gonzalez S, Iftimia N, Aleissa S, Navarrete-Dechent C, Dusza S, Rossi A, Marghoob AA, Rajadhyaksha M, Chen CJ. Angulated small nests and cords: Key diagnostic histopathologic features of infiltrative basal cell carcinoma can be identified using integrated reflectance confocal microscopy-optical coherence tomography. J Cutan Pathol. 2021 Jan;48(1):53-65. doi: 10.1111/cup.13871. Epub 2020 Oct 12. PMID: 32989842; PMCID: PMC7755835.en_US
dc.identifier.eissn1600-0560
dc.identifier.doi10.1111/cup.13871
dc.identifier.pmid32989842
dc.identifier.urihttp://hdl.handle.net/20.500.12648/7834
dc.description.abstractBackground: Accurate basal cell carcinoma (BCC) subtyping is requisite for appropriate management, but non-representative sampling occurs in 18% to 25% of biopsies. By enabling non-invasive diagnosis and more comprehensive sampling, integrated reflectance confocal microscopy-optical coherence tomography (RCM-OCT) may improve the accuracy of BCC subtyping and subsequent management. We evaluated RCM-OCT images and histopathology slides for the presence of two key features, angulation and small nests and cords, and calculated (a) sensitivity and specificity of these features, combined and individually, for identifying an infiltrative BCC subtype and (b) agreement across modalities. Methods: Thirty-three RCM-OCT-imaged, histopathologically-proven BCCs (17 superficial and/or nodular; 16 containing an infiltrative component) were evaluated. Results: The presence of angulation or small nests and cords was sufficient to identify infiltrative BCC on RCM-OCT with 100% sensitivity and 82% specificity, similar to histopathology (100% sensitivity, 88% specificity, kappa = 0.82). When both features were present, the sensitivity for identifying infiltrative BCC was 100% using either modality and specificity was 88% on RCM-OCT vs 94% on histopathology, indicating near-perfect agreement between non-invasive and invasive diagnostic modalities (kappa = 0.94). Conclusions: RCM-OCT can non-invasively identify key histopathologic features of infiltrative BCC offering a possible alternative to traditional invasive biopsy.en_US
dc.language.isoenen_US
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/epdf/10.1111/cup.13871en_US
dc.rights© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectbasal cell carcinomaen_US
dc.subjectbiopsyen_US
dc.subjecthistopathologyen_US
dc.subjectin vivo diagnosisen_US
dc.subjectoptical coherence tomographyen_US
dc.subjectreflectance confocal microscopyen_US
dc.titleAngulated small nests and cords: Key diagnostic histopathologic features of infiltrative basal cell carcinoma can be identified using integrated reflectance confocal microscopy-optical coherence tomography.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleJournal of cutaneous pathologyen_US
dc.source.volume48
dc.source.issue1
dc.source.beginpage53
dc.source.endpage65
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.description.versionAMen_US
refterms.dateFOA2022-11-02T16:43:30Z
dc.description.institutionSUNY Downstateen_US
dc.description.departmentPathologyen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalJournal of cutaneous pathology


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© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Except where otherwise noted, this item's license is described as © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.