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dc.contributor.authorCuriel-Lewandrowski, Clara
dc.contributor.authorMyrdal, Caitlyn N
dc.contributor.authorSaboda, Kathylynn
dc.contributor.authorHu, Chengcheng
dc.contributor.authorArzberger, Edith
dc.contributor.authorPellacani, Giovanni
dc.contributor.authorLegat, Franz Josef
dc.contributor.authorUlrich, Martina
dc.contributor.authorHochfellner, Petra
dc.contributor.authorOliviero, Margaret C
dc.contributor.authorPasquali, Paola
dc.contributor.authorGill, Melissa
dc.contributor.authorHofmann-Wellenhof, Rainer
dc.date.accessioned2022-11-02T16:36:42Z
dc.date.available2022-11-02T16:36:42Z
dc.date.issued2021-10-31
dc.identifier.citationCuriel-Lewandrowski C, Myrdal CN, Saboda K, Hu C, Arzberger E, Pellacani G, Legat FJ, Ulrich M, Hochfellner P, Oliviero MC, Pasquali P, Gill M, Hofmann-Wellenhof R. In Vivo Reflectance Confocal Microscopy as a Response Monitoring Tool for Actinic Keratoses Undergoing Cryotherapy and Photodynamic Therapy. Cancers (Basel). 2021 Oct 31;13(21):5488. doi: 10.3390/cancers13215488. PMID: 34771651; PMCID: PMC8583298.en_US
dc.identifier.issn2072-6694
dc.identifier.doi10.3390/cancers13215488
dc.identifier.pmid34771651
dc.identifier.urihttp://hdl.handle.net/20.500.12648/7832
dc.description.abstractReflectance confocal microscopy (RCM) presents a non-invasive method to image actinic keratosis (AK) at a cellular level. However, RCM criteria for AK response monitoring vary across studies and a universal, standardized approach is lacking. We aimed to identify reliable AK response criteria and to compare the clinical and RCM evaluation of responses across AK severity grades. Twenty patients were included and randomized to receive either cryotherapy ( = 10) or PDT ( = 10). Clinical assessment and RCM evaluation of 12 criteria were performed in AK lesions and photodamaged skin at baseline, 3 and 6 months. We identified the RCM criteria that reliably characterize AK at baseline and display significant reduction following treatment. Those with the highest baseline odds ratio (OR), good interobserver agreement, and most significant change over time were atypical honeycomb pattern (OR: 12.7, CI: 5.7-28.1), hyperkeratosis (OR: 13.6, CI: 5.3-34.9), stratum corneum disruption (OR: 7.8, CI: 3.5-17.3), and disarranged epidermal pattern (OR: 6.5, CI: 2.9-14.8). Clinical evaluation demonstrated a significant treatment response without relapse. However, in grade 2 AK, 10/12 RCM parameters increased from 3 to 6 months, which suggested early subclinical recurrence detection by RCM. Incorporating standardized RCM protocols for the assessment of AK may enable a more meaningful comparison across clinical trials, while allowing for the early detection of relapses and evaluation of biological responses to therapy over time.en_US
dc.language.isoenen_US
dc.relation.urlhttps://www.mdpi.com/2072-6694/13/21/5488en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectRCMen_US
dc.subjectactinic keratosisen_US
dc.subjectcryotherapyen_US
dc.subjectphotodynamic therapyen_US
dc.subjectreflectance confocal microscopyen_US
dc.subjectresponse monitoringen_US
dc.titleIn Vivo Reflectance Confocal Microscopy as a Response Monitoring Tool for Actinic Keratoses Undergoing Cryotherapy and Photodynamic Therapy.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleCancersen_US
dc.source.volume13
dc.source.issue21
dc.source.countryUnited States
dc.source.countrySwitzerland
dc.description.versionVoRen_US
refterms.dateFOA2022-11-02T16:36:43Z
dc.description.institutionSUNY Downstateen_US
dc.description.departmentPathologyen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalCancers


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International