Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction.
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AuthorKarlsson Linnér, Richard
Mallard, Travis T
Madole, James W
Driver, Morgan N
Poore, Holly E
de Vlaming, Ronald
Grotzinger, Andrew D
Tielbeek, Jorim J
Johnson, Emma C
Rosenthal, Sara Brin
Kember, Rachel L
Pasman, Joëlle A
Verweij, Karin J H
Liu, Dajiang J
Kranzler, Henry R
Harris, Kathleen Mullan
Tucker-Drob, Elliot M
Waldman, Irwin D
Palmer, Abraham A
Harden, K Paige
Koellinger, Philipp D
Dick, Danielle M
Journal titleNature neuroscience
Publication Begin page1367
Publication End page1376
MetadataShow full item record
AbstractBehaviors and disorders related to self-regulation, such as substance use, antisocial behavior and attention-deficit/hyperactivity disorder, are collectively referred to as externalizing and have shared genetic liability. We applied a multivariate approach that leverages genetic correlations among externalizing traits for genome-wide association analyses. By pooling data from ~1.5 million people, our approach is statistically more powerful than single-trait analyses and identifies more than 500 genetic loci. The loci were enriched for genes expressed in the brain and related to nervous system development. A polygenic score constructed from our results predicts a range of behavioral and medical outcomes that were not part of genome-wide analyses, including traits that until now lacked well-performing polygenic scores, such as opioid use disorder, suicide, HIV infections, criminal convictions and unemployment. Our findings are consistent with the idea that persistent difficulties in self-regulation can be conceptualized as a neurodevelopmental trait with complex and far-reaching social and health correlates.
CitationKarlsson Linnér R, Mallard TT, Barr PB, Sanchez-Roige S, Madole JW, Driver MN, Poore HE, de Vlaming R, Grotzinger AD, Tielbeek JJ, Johnson EC, Liu M, Rosenthal SB, Ideker T, Zhou H, Kember RL, Pasman JA, Verweij KJH, Liu DJ, Vrieze S; COGA Collaborators, Kranzler HR, Gelernter J, Harris KM, Tucker-Drob EM, Waldman ID, Palmer AA, Harden KP, Koellinger PD, Dick DM. Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction. Nat Neurosci. 2021 Oct;24(10):1367-1376. doi: 10.1038/s41593-021-00908-3. Epub 2021 Aug 26. PMID: 34446935; PMCID: PMC8484054.
The following license files are associated with this item:
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Except where otherwise noted, this item's license is described as © 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.
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