Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps.
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AuthorDick, Danielle M
Cho, Seung Bin
Cooke, Megan E
Kuo, Sally I-Chun
Lewis, Tenesha J
Salvatore, Jessica E
pathways of risk
Journal titleGenes, brain, and behavior
Publication Begin pagee12447
MetadataShow full item record
AbstractAs psychiatric genetics enters an era where gene identification is finally yielding robust, replicable genetic associations and polygenic risk scores, it is important to consider next steps and delineate how that knowledge will be applied to ultimately ameliorate suffering associated with substance use and psychiatric disorders. Much of the post-genome-wide association study discussion has focused on the potential of genetic information to elucidate the underlying biology and use this information for the development of more effective pharmaceutical treatments. In this review we focus on additional areas of research that should follow gene identification. By taking genetic findings into longitudinal, developmental studies, we can map the pathways by which genetic risk manifests across development, elucidating the early behavioral manifestations of risk, and studying how various environments and interventions moderate that risk across developmental stages. The delineation of risk across development will advance our understanding of mechanism, sex differences and risk and resilience processes in different racial/ethnic groups. Here, we review how the extant twin study literature can be used to guide these efforts. Together, these new lines of research will enable us to develop more informed, tailored prevention and intervention efforts.
CitationDick DM, Barr PB, Cho SB, Cooke ME, Kuo SI, Lewis TJ, Neale Z, Salvatore JE, Savage J, Su J. Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps. Genes Brain Behav. 2018 Mar;17(3):e12447. doi: 10.1111/gbb.12447. Epub 2018 Feb 5. PMID: 29227573; PMCID: PMC5876087.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as © 2017 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.
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