Mapping Pathways by Which Genetic Risk Influences Adolescent Externalizing Behavior: The Interplay Between Externalizing Polygenic Risk Scores, Parental Knowledge, and Peer Substance Use.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorKuo, Sally I-Chun
Salvatore, Jessica E
Bucholz, Kathleen K
Edenberg, Howard J
Kramer, John R
Mallard, Travis T
Nurnberger, John I
Plawecki, Martin H
Palmer, Abraham A
Dick, Danielle M
Journal titleBehavior genetics
Publication Begin page543
Publication End page558
MetadataShow full item record
AbstractGenetic predispositions and environmental influences both play an important role in adolescent externalizing behavior; however, they are not always independent. To elucidate gene-environment interplay, we examined the interrelationships between externalizing polygenic risk scores, parental knowledge, and peer substance use in impacting adolescent externalizing behavior across two time-points in a high-risk longitudinal sample of 1,200 adolescents (764 European and 436 African ancestry; M = 12.99) from the Collaborative Study on the Genetics of Alcoholism. Results from multivariate path analysis indicated that externalizing polygenic scores were directly associated with adolescent externalizing behavior but also indirectly via peer substance use, in the European ancestry sample. No significant polygenic association nor indirect effects of genetic risk were observed in the African ancestry group, likely due to more limited power. Our findings underscore the importance of gene-environment interplay and suggest peer substance use may be a mechanism through which genetic risk influences adolescent externalizing behavior.
CitationKuo SI, Salvatore JE, Barr PB, Aliev F, Anokhin A, Bucholz KK, Chan G, Edenberg HJ, Hesselbrock V, Kamarajan C, Kramer JR, Lai D, Mallard TT, Nurnberger JI Jr, Pandey G, Plawecki MH, Sanchez-Roige S, Waldman I, Palmer AA; Externalizing Consortium, Dick DM. Mapping Pathways by Which Genetic Risk Influences Adolescent Externalizing Behavior: The Interplay Between Externalizing Polygenic Risk Scores, Parental Knowledge, and Peer Substance Use. Behav Genet. 2021 Sep;51(5):543-558. doi: 10.1007/s10519-021-10067-7. Epub 2021 Jun 12. PMID: 34117972; PMCID: PMC8403154.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as © 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
- The Associations of Polygenic Scores for Risky Behaviors and Parenting Behaviors with Adolescent Externalizing Problems.
- Authors: Ksinan AJ, Smith RL, Barr PB, Vazsonyi AT
- Issue date: 2022 Jan
- The role of parental genotype in the intergenerational transmission of externalizing behavior: Evidence for genetic nurturance.
- Authors: Kuo SI, Poore HE, Barr PB, Chirico IS, Aliev F, Bucholz KK, Chan G, Kamarajan C, Kramer JR, McCutcheon VV, Plawecki MH, Dick DM
- Issue date: 2022 Oct 6
- Roles of Response Inhibition and Gene-Environment Interplay in Pathways to Adolescents' Externalizing Problems.
- Authors: Wang FL, Chassin L, Lee M, Haller M, King K
- Issue date: 2017 Jun
- Affiliation with substance-using peers: Examining gene-environment correlations among parent monitoring, polygenic risk, and children's impulsivity.
- Authors: Elam KK, Chassin L, Lemery-Chalfant K, Pandika D, Wang FL, Bountress K, Dick D, Agrawal A
- Issue date: 2017 Jul
- Gene-environment interplay in externalizing behavior from childhood through adulthood.
- Authors: Kretschmer T, Vrijen C, Nolte IM, Wertz J, Hartman CA
- Issue date: 2022 Oct