Mapping Pathways by Which Genetic Risk Influences Adolescent Externalizing Behavior: The Interplay Between Externalizing Polygenic Risk Scores, Parental Knowledge, and Peer Substance Use.
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Author
Kuo, Sally I-ChunSalvatore, Jessica E
Barr, Peter
Aliev, Fazil
Anokhin, Andrey
Bucholz, Kathleen K
Chan, Grace
Edenberg, Howard J
Hesselbrock, Victor
Kamarajan, Chella
Kramer, John R
Lai, Dongbing
Mallard, Travis T
Nurnberger, John I
Pandey, Gayathri
Plawecki, Martin H
Sanchez-Roige, Sandra
Waldman, Irwin
Palmer, Abraham A
Dick, Danielle M
Journal title
Behavior geneticsDate Published
2021-06-12Publication Volume
51Publication Issue
5Publication Begin page
543Publication End page
558
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Show full item recordAbstract
Genetic predispositions and environmental influences both play an important role in adolescent externalizing behavior; however, they are not always independent. To elucidate gene-environment interplay, we examined the interrelationships between externalizing polygenic risk scores, parental knowledge, and peer substance use in impacting adolescent externalizing behavior across two time-points in a high-risk longitudinal sample of 1,200 adolescents (764 European and 436 African ancestry; M = 12.99) from the Collaborative Study on the Genetics of Alcoholism. Results from multivariate path analysis indicated that externalizing polygenic scores were directly associated with adolescent externalizing behavior but also indirectly via peer substance use, in the European ancestry sample. No significant polygenic association nor indirect effects of genetic risk were observed in the African ancestry group, likely due to more limited power. Our findings underscore the importance of gene-environment interplay and suggest peer substance use may be a mechanism through which genetic risk influences adolescent externalizing behavior.Citation
Kuo SI, Salvatore JE, Barr PB, Aliev F, Anokhin A, Bucholz KK, Chan G, Edenberg HJ, Hesselbrock V, Kamarajan C, Kramer JR, Lai D, Mallard TT, Nurnberger JI Jr, Pandey G, Plawecki MH, Sanchez-Roige S, Waldman I, Palmer AA; Externalizing Consortium, Dick DM. Mapping Pathways by Which Genetic Risk Influences Adolescent Externalizing Behavior: The Interplay Between Externalizing Polygenic Risk Scores, Parental Knowledge, and Peer Substance Use. Behav Genet. 2021 Sep;51(5):543-558. doi: 10.1007/s10519-021-10067-7. Epub 2021 Jun 12. PMID: 34117972; PMCID: PMC8403154.DOI
10.1007/s10519-021-10067-7ae974a485f413a2113503eed53cd6c53
10.1007/s10519-021-10067-7
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Except where otherwise noted, this item's license is described as © 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.