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dc.contributor.authorPerzanowski, Matthew S
dc.contributor.authorChew, Ginger L
dc.contributor.authorDivjan, Adnan
dc.contributor.authorJohnson, Alina
dc.contributor.authorGoldstein, Inge F
dc.contributor.authorGarfinkel, Robin S
dc.contributor.authorHoepner, Lori A
dc.contributor.authorPlatts-Mills, Thomas A E
dc.contributor.authorPerera, Frederica P
dc.contributor.authorMiller, Rachel L
dc.date.accessioned2022-10-12T18:10:06Z
dc.date.available2022-10-12T18:10:06Z
dc.identifier.citationPerzanowski MS, Chew GL, Divjan A, Johnson A, Goldstein IF, Garfinkel RS, Hoepner LA, Platts-Mills TA, Perera FP, Miller RL. Cat ownership is a risk factor for the development of anti-cat IgE but not current wheeze at age 5 years in an inner-city cohort. J Allergy Clin Immunol. 2008 Apr;121(4):1047-52. doi: 10.1016/j.jaci.2008.02.005. PMID: 18395554; PMCID: PMC3131176.en_US
dc.identifier.eissn1097-6825
dc.identifier.doi10.1016/j.jaci.2008.02.005
dc.identifier.pmid18395554
dc.identifier.urihttp://hdl.handle.net/20.500.12648/7739
dc.description.abstractBackground: Cat ownership is inversely associated with atopy and asthma in some areas of the world, but the relevance of cat ownership to allergic disease in the inner city is less known. Objective: We sought to evaluate the relationship between cat ownership and the development of early sensitization and wheeze. Methods: By using a prospective birth cohort study, Dominican and African American mothers living in New York City underwent repeated questionnaires about their child from birth to age 5 years. Sera collected from children at ages 2 (n = 323), 3 (n = 336), and 5 (n = 242) years were assayed for anti-cat IgE and anti-Fel d 1 IgG antibodies. Results: Cat ownership was a significant risk factor for the development of anti-cat IgE by age 2 years (risk ratio [RR], 6.4; 95% CI, 1.9-22) but not for anti-cat IgE development between the ages of 2 and 5 years (RR, 0.88; 95% CI, 0.24-2.3). Current wheeze was significantly more common among those children with anti-cat IgE at ages 3 (RR, 3.5; 95% CI, 2.1-6.0) and 5 (RR, 3.4; 95% CI, 2.3-4.9) years. Cat ownership was inversely associated with current wheeze at age 5 years among children without anti-cat IgE (RR, 0.26; 95% CI, 0.083-0.81). Among children with anti-cat IgE, a similar trend was observed (RR, 0.57; P = .044, Fisher exact test), although one with borderline statistical significance. Conclusions: Despite a positive association with sensitization, cat ownership in this inner-city cohort was inversely associated with wheeze, potentially suggesting an IgE-independent protective mechanism in this community.en_US
dc.language.isoenen_US
dc.relation.urlhttps://www.jacionline.org/article/S0091-6749(08)00352-7/fulltexten_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleCat ownership is a risk factor for the development of anti-cat IgE but not current wheeze at age 5 years in an inner-city cohort.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleThe Journal of allergy and clinical immunologyen_US
dc.source.volume121
dc.source.issue4
dc.source.beginpage1047
dc.source.endpage52
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.description.versionVoRen_US
refterms.dateFOA2022-10-12T18:10:06Z
dc.description.institutionSUNY Downstateen_US
dc.description.departmentEnvironmental and Occupational Health Sciencesen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalThe Journal of allergy and clinical immunology


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