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dc.contributor.authorDonohue, Kathleen M
dc.contributor.authorAl-alem, Umaima
dc.contributor.authorPerzanowski, Matthew S
dc.contributor.authorChew, Ginger L
dc.contributor.authorJohnson, Alina
dc.contributor.authorDivjan, Adnan
dc.contributor.authorKelvin, Elizabeth A
dc.contributor.authorHoepner, Lori A
dc.contributor.authorPerera, Frederica P
dc.contributor.authorMiller, Rachel L
dc.date.accessioned2022-10-12T18:04:13Z
dc.date.available2022-10-12T18:04:13Z
dc.identifier.citationDonohue KM, Al-alem U, Perzanowski MS, Chew GL, Johnson A, Divjan A, Kelvin EA, Hoepner LA, Perera FP, Miller RL. Anti-cockroach and anti-mouse IgE are associated with early wheeze and atopy in an inner-city birth cohort. J Allergy Clin Immunol. 2008 Nov;122(5):914-20. doi: 10.1016/j.jaci.2008.08.034. PMID: 19000580; PMCID: PMC2590748.en_US
dc.identifier.eissn1097-6825
dc.identifier.doi10.1016/j.jaci.2008.08.034
dc.identifier.pmid19000580
dc.identifier.urihttp://hdl.handle.net/20.500.12648/7737
dc.description.abstractBackground: The relationships between cockroach and mouse allergen exposure, anti-cockroach and anti-mouse IgE, and wheeze, rhinitis, and atopic dermatitis in children as young as age 3 years are of public health importance but have not been thoroughly evaluated. Objective: We hypothesized that inner-city children might have anti-cockroach and anti-mouse IgE by age 3 years, and their presence would be associated with respiratory and atopic symptoms. Methods: Children were followed prospectively from birth through age 3 years (n = 404). Residential levels of cockroach and mouse allergens, sera levels of anti-cockroach and anti-mouse IgE, and parental report of wheeze, rhinitis, and atopic dermatitis were measured. Results: The odds of early wheeze were significantly higher among children who had IgE to cockroach (odds ratio [OR], 3.3; 95% CI, 1.8-6.2), mouse (OR, 4.6; 95% CI, 2.3-9.0), or both (OR, 9.7; 95% CI, 3.4-27.3). The odds of rhinitis or atopic dermatitis were also higher among children with IgE to cockroach, mouse, or both. Higher IgE class to cockroach and mouse was associated with wheeze and atopic dermatitis (tests for trend, P < .002). Conclusions: Children age 2 to 3 years who have anti-cockroach and anti-mouse IgE are at increased risk of wheeze and atopy. Moreover, a dose-response relationship was found between higher IgE class and increased prevalence of wheeze, rhinitis, or atopic dermatitis. These findings indicate the importance of reducing exposure to cockroach and mouse allergens for susceptible children.en_US
dc.language.isoenen_US
dc.relation.urlhttps://www.jacionline.org/article/S0091-6749(08)01667-9/fulltexten_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleAnti-cockroach and anti-mouse IgE are associated with early wheeze and atopy in an inner-city birth cohort.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleThe Journal of allergy and clinical immunologyen_US
dc.source.volume122
dc.source.issue5
dc.source.beginpage914
dc.source.endpage20
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.description.versionVoRen_US
refterms.dateFOA2022-10-12T18:04:14Z
dc.description.institutionSUNY Downstateen_US
dc.description.departmentEnvironmental and Occupational Health Sciencesen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalThe Journal of allergy and clinical immunology


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