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dc.contributor.authorWhyatt, Robin M
dc.contributor.authorGarfinkel, Robin
dc.contributor.authorHoepner, Lori A
dc.contributor.authorAndrews, Howard
dc.contributor.authorHolmes, Darrell
dc.contributor.authorWilliams, Megan K
dc.contributor.authorReyes, Andria
dc.contributor.authorDiaz, Diurka
dc.contributor.authorPerera, Frederica P
dc.contributor.authorCamann, David E
dc.contributor.authorBarr, Dana B
dc.date.accessioned2022-10-12T17:59:13Z
dc.date.available2022-10-12T17:59:13Z
dc.date.issued2008-12-05
dc.identifier.citationWhyatt RM, Garfinkel R, Hoepner LA, Andrews H, Holmes D, Williams MK, Reyes A, Diaz D, Perera FP, Camann DE, Barr DB. A biomarker validation study of prenatal chlorpyrifos exposure within an inner-city cohort during pregnancy. Environ Health Perspect. 2009 Apr;117(4):559-67. doi: 10.1289/ehp.0800041. Epub 2008 Dec 5. PMID: 19440494; PMCID: PMC2679599.en_US
dc.identifier.eissn1552-9924
dc.identifier.doi10.1289/ehp.0800041
dc.identifier.pmid19440494
dc.identifier.urihttp://hdl.handle.net/20.500.12648/7735
dc.description.abstractBackground: We previously documented significant decreases in chlorpyrifos concentrations in maternal personal and indoor air samples among pregnant African-American and Dominican women from New York City after the 2000-2001 restrictions on its residential use. Objective: We undertook a biomarker validation study within the same cohort to evaluate trends over time in multiple biomarkers of prenatal chlorpyrifos exposure. Methods: Subjects were enrolled between February 2001 and May 2004 (n = 102). We measured 3,5,6-trichloro-2-pyridinol (TCPy) in postpartum meconium (n = 83), repeat prenatal maternal spot urine samples (n = 253), and postnatal urine from the mothers (n = 73) and newborns (n = 59). We measured chlorpyrifos in postnatal maternal (n = 92) and umbilical cord (n = 65) blood. Results: We did not detect TCPy in infant urine, but all other biomarkers showed a highly significant decrease in detection frequencies (chi2 = 7.8-34.0, p < or = 0.005) and mean ranks (p < or = 0.006, Kruskal-Wallis) among subjects enrolled in 2003-2004 compared with those enrolled in 2001-2002. Chlorpyrifos in maternal personal and indoor air declined 2- to 3-fold over the same period (p < 0.05). In 2001-2002 samples, TCPy levels in repeat prenatal urine were positively correlated (r = 0.23-0.56), but within-subject variability exceeded between-subject variability (intraclass correlation coefficient = 0.43); indoor air levels explained 19% of the variance in prenatal urine TCPy (p = 0.001). Meconium TCPy concentrations were positively correlated with chlorpyrifos in maternal and cord blood (r = 0.25-0.33, p < 0.05) and with TCPy in maternal urine (r = 0.31, p < 0.01). Conclusions: Results suggest the biomarkers are reliable dosimeters to differentiate between groups with prenatal chlorpyrifos exposures varying by a factor of 2 or more and vividly illustrate the efficacy of residential restriction on chlorpyrifos to reduce the internal dose during pregnancy.en_US
dc.language.isoenen_US
dc.relation.urlhttps://ehp.niehs.nih.gov/doi/10.1289/ehp.0800041en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectbiomarkersen_US
dc.subjectchlorpyrifosen_US
dc.subjectcord blooden_US
dc.subjectindoor airen_US
dc.subjectmaternal blooden_US
dc.subjectmeconiumen_US
dc.subjectpregnancyen_US
dc.subjecturineen_US
dc.titleA biomarker validation study of prenatal chlorpyrifos exposure within an inner-city cohort during pregnancy.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleEnvironmental health perspectivesen_US
dc.source.volume117
dc.source.issue4
dc.source.beginpage559
dc.source.endpage67
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.description.versionVoRen_US
refterms.dateFOA2022-10-12T17:59:14Z
dc.description.institutionSUNY Downstateen_US
dc.description.departmentEnvironmental and Occupational Health Sciencesen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalEnvironmental health perspectives


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