A biomarker validation study of prenatal chlorpyrifos exposure within an inner-city cohort during pregnancy.
dc.contributor.author | Whyatt, Robin M | |
dc.contributor.author | Garfinkel, Robin | |
dc.contributor.author | Hoepner, Lori A | |
dc.contributor.author | Andrews, Howard | |
dc.contributor.author | Holmes, Darrell | |
dc.contributor.author | Williams, Megan K | |
dc.contributor.author | Reyes, Andria | |
dc.contributor.author | Diaz, Diurka | |
dc.contributor.author | Perera, Frederica P | |
dc.contributor.author | Camann, David E | |
dc.contributor.author | Barr, Dana B | |
dc.date.accessioned | 2022-10-12T17:59:13Z | |
dc.date.available | 2022-10-12T17:59:13Z | |
dc.date.issued | 2008-12-05 | |
dc.identifier.citation | Whyatt RM, Garfinkel R, Hoepner LA, Andrews H, Holmes D, Williams MK, Reyes A, Diaz D, Perera FP, Camann DE, Barr DB. A biomarker validation study of prenatal chlorpyrifos exposure within an inner-city cohort during pregnancy. Environ Health Perspect. 2009 Apr;117(4):559-67. doi: 10.1289/ehp.0800041. Epub 2008 Dec 5. PMID: 19440494; PMCID: PMC2679599. | en_US |
dc.identifier.eissn | 1552-9924 | |
dc.identifier.doi | 10.1289/ehp.0800041 | |
dc.identifier.pmid | 19440494 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12648/7735 | |
dc.description.abstract | Background: We previously documented significant decreases in chlorpyrifos concentrations in maternal personal and indoor air samples among pregnant African-American and Dominican women from New York City after the 2000-2001 restrictions on its residential use. Objective: We undertook a biomarker validation study within the same cohort to evaluate trends over time in multiple biomarkers of prenatal chlorpyrifos exposure. Methods: Subjects were enrolled between February 2001 and May 2004 (n = 102). We measured 3,5,6-trichloro-2-pyridinol (TCPy) in postpartum meconium (n = 83), repeat prenatal maternal spot urine samples (n = 253), and postnatal urine from the mothers (n = 73) and newborns (n = 59). We measured chlorpyrifos in postnatal maternal (n = 92) and umbilical cord (n = 65) blood. Results: We did not detect TCPy in infant urine, but all other biomarkers showed a highly significant decrease in detection frequencies (chi2 = 7.8-34.0, p < or = 0.005) and mean ranks (p < or = 0.006, Kruskal-Wallis) among subjects enrolled in 2003-2004 compared with those enrolled in 2001-2002. Chlorpyrifos in maternal personal and indoor air declined 2- to 3-fold over the same period (p < 0.05). In 2001-2002 samples, TCPy levels in repeat prenatal urine were positively correlated (r = 0.23-0.56), but within-subject variability exceeded between-subject variability (intraclass correlation coefficient = 0.43); indoor air levels explained 19% of the variance in prenatal urine TCPy (p = 0.001). Meconium TCPy concentrations were positively correlated with chlorpyrifos in maternal and cord blood (r = 0.25-0.33, p < 0.05) and with TCPy in maternal urine (r = 0.31, p < 0.01). Conclusions: Results suggest the biomarkers are reliable dosimeters to differentiate between groups with prenatal chlorpyrifos exposures varying by a factor of 2 or more and vividly illustrate the efficacy of residential restriction on chlorpyrifos to reduce the internal dose during pregnancy. | en_US |
dc.language.iso | en | en_US |
dc.relation.url | https://ehp.niehs.nih.gov/doi/10.1289/ehp.0800041 | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | biomarkers | en_US |
dc.subject | chlorpyrifos | en_US |
dc.subject | cord blood | en_US |
dc.subject | indoor air | en_US |
dc.subject | maternal blood | en_US |
dc.subject | meconium | en_US |
dc.subject | pregnancy | en_US |
dc.subject | urine | en_US |
dc.title | A biomarker validation study of prenatal chlorpyrifos exposure within an inner-city cohort during pregnancy. | en_US |
dc.type | Article/Review | en_US |
dc.source.journaltitle | Environmental health perspectives | en_US |
dc.source.volume | 117 | |
dc.source.issue | 4 | |
dc.source.beginpage | 559 | |
dc.source.endpage | 67 | |
dc.source.country | United States | |
dc.source.country | United States | |
dc.source.country | United States | |
dc.source.country | United States | |
dc.source.country | United States | |
dc.source.country | United States | |
dc.source.country | United States | |
dc.source.country | United States | |
dc.description.version | VoR | en_US |
refterms.dateFOA | 2022-10-12T17:59:14Z | |
dc.description.institution | SUNY Downstate | en_US |
dc.description.department | Environmental and Occupational Health Sciences | en_US |
dc.description.degreelevel | N/A | en_US |
dc.identifier.journal | Environmental health perspectives |