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dc.contributor.authorOlmedo, Omar
dc.contributor.authorGoldstein, Inge F
dc.contributor.authorAcosta, Luis
dc.contributor.authorDivjan, Adnan
dc.contributor.authorRundle, Andrew G
dc.contributor.authorChew, Ginger L
dc.contributor.authorMellins, Robert B
dc.contributor.authorHoepner, Lori
dc.contributor.authorAndrews, Howard
dc.contributor.authorLopez-Pintado, Sara
dc.contributor.authorQuinn, James W
dc.contributor.authorPerera, Frederica P
dc.contributor.authorMiller, Rachel L
dc.contributor.authorJacobson, Judith S
dc.contributor.authorPerzanowski, Matthew S
dc.date.accessioned2022-10-11T18:57:19Z
dc.date.available2022-10-11T18:57:19Z
dc.date.issued2011-05-04
dc.identifier.citationReyes M, Perzanowski MS, Whyatt RM, Kelvin EA, Rundle AG, Diaz DM, Hoepner L, Perera FP, Rauh V, Miller RL. Relationship between maternal demoralization, wheeze, and immunoglobulin E among inner-city children. Ann Allergy Asthma Immunol. 2011 Jul;107(1):42-49.e1. doi: 10.1016/j.anai.2011.03.004. Epub 2011 Apr 14. PMID: 21704884; PMCID: PMC3135280.en_US
dc.identifier.eissn1097-6825
dc.identifier.doi10.1016/j.jaci.2011.02.044
dc.identifier.pmid21536321
dc.identifier.urihttp://hdl.handle.net/20.500.12648/7723
dc.description.abstractBackground: Prior research has linked maternal prenatal and postnatal mental health with the subsequent development of asthma in children. However, this relationship has not been examined in inner-city African Americans and Hispanics, populations at high risk for asthma. Objective: To determine the relationship of maternal demoralization with wheeze, specific wheeze phenotypes, and seroatopy among children living in a low-income, urban community. Methods: African American and Dominican women aged 18 to 35 years residing in New York City (the Bronx and Northern Manhattan) were recruited during pregnancy (n = 279). Maternal demoralization (ie, psychological distress) was measured both prenatally and postnatally by validated questionnaire. Outcomes included wheeze, transient (birth to 2.5 years of age), late onset (3-5 years), and persistent (birth to 5 years of age), evaluated via questionnaire and total and indoor allergen specific IgE (at birth and ages 2, 3, and 5 years). Logistic regression with generalized estimating equations assessed the association of demoralization with wheeze and atopy. Multinomial regression explored associations between demoralization and specific wheeze phenotypes. Results: Prenatal demoralization significantly predicted overall wheeze (adjusted odds ratio OR, 1.66; 95% confidence interval [CI], 1.29-2.14), transient wheeze (OR, 2.25; 95% CI, 1.34-3.76), and persistent wheeze (OR, 2.69; 95% CI, 1.52-4.77). No association was found between demoralization and IgE after adjustment (total IgE: OR, 1.04; 95% CI, 0.74-1.45; any specific IgE: OR, 0.96; 95% CI, 0.57-1.60). Conclusions: In this inner-city cohort, prenatal demoralization was associated with transient and persistent wheeze. Understanding how maternal demoralization influences children's respiratory health may be important for developing effective interventions among disadvantaged populations.en_US
dc.language.isoenen_US
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/S1081120611001840en_US
dc.rightsCopyright © 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleNeighborhood differences in exposure and sensitization to cockroach, mouse, dust mite, cat, and dog allergens in New York City.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleThe Journal of allergy and clinical immunologyen_US
dc.source.volume128
dc.source.issue2
dc.source.beginpage284
dc.source.endpage292.e7
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.description.versionVoRen_US
refterms.dateFOA2022-10-11T18:57:19Z
dc.description.institutionSUNY Downstateen_US
dc.description.departmentEnvironmental and Occupational Health Sciencesen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalThe Journal of allergy and clinical immunology


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Copyright © 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
Except where otherwise noted, this item's license is described as Copyright © 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.