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dc.contributor.authorHerbstman, Julie B
dc.contributor.authorWang, Shuang
dc.contributor.authorPerera, Frederica P
dc.contributor.authorLederman, Sally A
dc.contributor.authorVishnevetsky, Julia
dc.contributor.authorRundle, Andrew G
dc.contributor.authorHoepner, Lori A
dc.contributor.authorQu, Lirong
dc.contributor.authorTang, Deliang
dc.date.accessioned2022-10-11T16:58:10Z
dc.date.available2022-10-11T16:58:10Z
dc.date.issued2013-09-04
dc.identifier.citationHerbstman JB, Wang S, Perera FP, Lederman SA, Vishnevetsky J, Rundle AG, Hoepner LA, Qu L, Tang D. Predictors and consequences of global DNA methylation in cord blood and at three years. PLoS One. 2013 Sep 4;8(9):e72824. doi: 10.1371/journal.pone.0072824. PMID: 24023780; PMCID: PMC3762861.en_US
dc.identifier.eissn1932-6203
dc.identifier.doi10.1371/journal.pone.0072824
dc.identifier.pmid24023780
dc.identifier.urihttp://hdl.handle.net/20.500.12648/7711
dc.description.abstractDNA methylation changes have been implicated in many common chronic diseases leading to the hypothesis that environmental and age-related DNA methylation changes within individuals are involved in disease etiology. Few studies have examined DNA methylation changes within an individual over time and all of these studies have been conducted in adults. Here, we aim to characterize how global DNA methylation changes from birth to age three within a longitudinal birth cohort study and to determine whether there are consistent predictors of DNA methylation levels measured three years apart. We measured global DNA methylation in the same children at birth (cord blood) and again at three years of age among 165 children, using an immunoassay. We found that on average, DNA methylation was significantly higher in blood at age 3-years than in cord blood (p<0.01). However, for any individual child, the difference was less than would be expected by chance. We found that pre-pregnancy BMI was negatively predictive of both cord and three-year DNA methylation, even after statistical adjustment to account for the correlation between cord blood and three-year DNA methylation. The biologic implications of small changes in global DNA methylation are unknown. However, the observation that global DNA methylation levels persist within an individual from birth to age three supports the belief that factors that influence global DNA methylation, including pre-pregnancy BMI, may confer long-term effects.en_US
dc.language.isoenen_US
dc.relation.urlhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072824en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titlePredictors and consequences of global DNA methylation in cord blood and at three years.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitlePloS oneen_US
dc.source.volume8
dc.source.issue9
dc.source.beginpagee72824
dc.source.endpage
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.description.versionVoRen_US
refterms.dateFOA2022-10-11T16:58:11Z
dc.description.institutionSUNY Downstateen_US
dc.description.departmentEnvironmental and Occupational Health Sciencesen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalPloS one


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