Association of recent exposure to ambient metals on fractional exhaled nitric oxide in 9-11 year old inner-city children.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorRosa, Maria José
Perzanowski, Matthew S
Chillrud, Steven N
Perera, Frederica P
Miller, Rachel L
Journal titleNitric oxide : biology and chemistry
Publication Begin page60
Publication End page6
MetadataShow full item record
AbstractExposure to ambient metals in urban environments has been associated with wheeze, and emergency room visits and hospitalizations due to respiratory illness. However, the effect of ambient metals exposure on airway inflammation, and how these associations may be modified by seroatopy, has not been determined. Fractional exhaled nitric oxide (FENO) is a reliable proxy marker of airway inflammation. We hypothesized that recent ambient concentrations of Ni, V, Zn and Fe would be associated differentially with proximal and distal fractions of exhaled NO, and that these associations would be modified by seroatopy. As part of the Columbia Center for Children's Environmental Health (CCCEH) birth cohort study, 9-11 year old children (n=192) were evaluated. Ambient measures of Ni, V, Zn and Fe were obtained from a local central monitoring site and averaged over 9 days based on three 24h measures every third day. Fractional exhaled nitric oxide (FENO) samples were obtained at constant flows of 50 (FENO50), 83 and 100mL/s, and used to determine surrogate measures for proximal (JNO) and alveolar (Calv) inflammation. Seroatopy was determined by specific IgE at age 7. Data were analyzed using multivariable linear regression. Ambient V and Fe concentrations were associated positively with FENO50 (p=0.018, p=0.027). Ambient Fe was associated positively with JNO (p=0.017). Ambient Ni and V concentrations were associated positively with Calv (p=0.004, p=0.018, respectively). A stronger association of Ni concentrations with Calv was observed among the children with seroatopy. These results suggest that ambient metals are associated differentially with different fractions of FENO production, and this relationship may be modified by seroatopy.
CitationRosa MJ, Perzanowski MS, Divjan A, Chillrud SN, Hoepner L, Zhang H, Ridder R, Perera FP, Miller RL. Association of recent exposure to ambient metals on fractional exhaled nitric oxide in 9-11 year old inner-city children. Nitric Oxide. 2014 Aug 31;40:60-6. doi: 10.1016/j.niox.2014.05.008. Epub 2014 May 27. PMID: 24878380; PMCID: PMC4133318.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Copyright © 2014 Elsevier Inc. All rights reserved.
- Children's urinary phthalate metabolites and fractional exhaled nitric oxide in an urban cohort.
- Authors: Just AC, Whyatt RM, Miller RL, Rundle AG, Chen Q, Calafat AM, Divjan A, Rosa MJ, Zhang H, Perera FP, Goldstein IF, Perzanowski MS
- Issue date: 2012 Nov 1
- Exhaled NO among inner-city children in New York City.
- Authors: Perzanowski MS, Divjan A, Mellins RB, Canfield SM, Rosa MJ, Chew GL, Rundle A, Goldstein IF, Jacobson JS
- Issue date: 2010 Nov
- Fractional exhaled nitric oxide exchange parameters among 9-year-old inner-city children.
- Authors: Rosa MJ, Divjan A, Hoepner L, Sheares BJ, Diaz D, Gauvey-Kern K, Perera FP, Miller RL, Perzanowski MS
- Issue date: 2011 Jan
- Trace metal exposure is associated with increased exhaled nitric oxide in asthmatic children.
- Authors: Godri Pollitt KJ, Maikawa CL, Wheeler AJ, Weichenthal S, Dobbin NA, Liu L, Goldberg MS
- Issue date: 2016 Sep 1
- Personal Exposure to Black Carbon at School and Levels of Fractional Exhaled Nitric Oxide in New York City.
- Authors: Jung KH, Goodwin KE, Perzanowski MS, Chillrud SN, Perera FP, Miller RL, Lovinsky-Desir S
- Issue date: 2021 Sep