Asthma in inner-city children at 5-11 years of age and prenatal exposure to phthalates: the Columbia Center for Children's Environmental Health Cohort.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorWhyatt, Robin M
Perzanowski, Matthew S
Just, Allan C
Rundle, Andrew G
Donohue, Kathleen M
Calafat, Antonia M
Hoepner, Lori A
Perera, Frederica P
Miller, Rachel L
Journal titleEnvironmental health perspectives
Publication Begin page1141
Publication End page6
MetadataShow full item record
AbstractBackground: Studies suggest that phthalate exposures may adversely affect child respiratory health. Objectives: We evaluated associations between asthma diagnosed in children between 5 and 11 years of age and prenatal exposures to butylbenzyl phthalate (BBzP), di-n-butyl phthalate (DnBP), di(2-ethylhexyl) phthalate (DEHP), and diethyl phthalate (DEP). Methods: Phthalate metabolites were measured in spot urine collected from 300 pregnant inner-city women. Children were examined by an allergist or pulmonologist based on the first parental report of wheeze, other respiratory symptoms, and/or use of asthma rescue/controller medication in the preceding 12 months on repeat follow-up questionnaires. Standardized diagnostic criteria were used to classify these children as either having or not having current asthma at the time of the physician examination. Children without any report of wheeze or the other asthma-like symptoms were classified as nonasthmatics at the time of the last negative questionnaire. Modified Poisson regression analyses were used to estimate relative risks (RR) controlling for specific gravity and potential confounders. Results: Of 300 children, 154 (51%) were examined by a physician because of reports of wheeze, other asthma-like symptoms, and/or medication use; 94 were diagnosed with current asthma and 60 without current asthma. The remaining 146 children were classified as nonasthmatic. Compared with levels in nonasthmatics, prenatal metabolites of BBzP and DnBP were associated with a history of asthma-like symptoms (p < 0.05) and with the diagnosis of current asthma: RR = 1.17 (95% CI: 1.01, 1.35) and RR = 1.25 (95% CI: 1.04, 1.51) per natural log-unit increase, respectively. Risk of current asthma was > 70% higher among children with maternal prenatal BBzP and DnBP metabolite concentrations in the third versus the first tertile. Conclusion: Prenatal exposure to BBzP and DnBP may increase the risk of asthma among inner-city children. However, because this is the first such finding, results require replication.
CitationWhyatt RM, Perzanowski MS, Just AC, Rundle AG, Donohue KM, Calafat AM, Hoepner LA, Perera FP, Miller RL. Asthma in inner-city children at 5-11 years of age and prenatal exposure to phthalates: the Columbia Center for Children's Environmental Health Cohort. Environ Health Perspect. 2014 Oct;122(10):1141-6. doi: 10.1289/ehp.1307670. Epub 2014 Sep 17. PMID: 25230320; PMCID: PMC4181924.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International
- Children's urinary phthalate metabolites and fractional exhaled nitric oxide in an urban cohort.
- Authors: Just AC, Whyatt RM, Miller RL, Rundle AG, Chen Q, Calafat AM, Divjan A, Rosa MJ, Zhang H, Perera FP, Goldstein IF, Perzanowski MS
- Issue date: 2012 Nov 1
- Persistent Associations between Maternal Prenatal Exposure to Phthalates on Child IQ at Age 7 Years.
- Authors: Factor-Litvak P, Insel B, Calafat AM, Liu X, Perera F, Rauh VA, Whyatt RM
- Issue date: 2014
- A combined cohort analysis of prenatal exposure to phthalate mixtures and childhood asthma.
- Authors: Adgent MA, Carroll KN, Hazlehurst MF, Loftus CT, Szpiro AA, Karr CJ, Barrett ES, LeWinn KZ, Bush NR, Tylavsky FA, Kannan K, Sathyanarayana S
- Issue date: 2020 Oct
- Prenatal Phthalate Exposures and Childhood Fat Mass in a New York City Cohort.
- Authors: Buckley JP, Engel SM, Mendez MA, Richardson DB, Daniels JL, Calafat AM, Wolff MS, Herring AH
- Issue date: 2016 Apr
- Phthalate metabolites in urine of children and adolescents in Germany. Human biomonitoring results of the German Environmental Survey GerES V, 2014-2017.
- Authors: Schwedler G, Rucic E, Lange R, Conrad A, Koch HM, Pälmke C, Brüning T, Schulz C, Schmied-Tobies MIH, Daniels A, Kolossa-Gehring M
- Issue date: 2020 Apr