Physical activity, black carbon exposure and airway inflammation in an urban adolescent cohort.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Jung, Kyung Hwa
Rundle, Andrew G
Hoepner, Lori A
Bautista, Joshua B
Perera, Frederica P
Chillrud, Steven N
Perzanowski, Matthew S
Miller, Rachel L
Journal titleEnvironmental research
Publication Begin page756
Publication End page762
MetadataShow full item record
AbstractObjective: Regular physical activity can improve cardiopulmonary health; however, increased respiratory rates and tidal volumes during activity may increase the effective internal dose of air pollution exposure. Our objective was to investigate the impact of black carbon (BC) measured by personal sampler on the relationship between physical activity and fractional exhaled nitric oxide (FeNO), a marker of airway inflammation. We hypothesized that higher personal BC would attenuate the protective effect of physical activity on airway inflammation. Methods: We performed a cross-sectional study nested in a birth cohort of African American and Dominican children living in the Bronx and Northern Manhattan, New York City. Children were recruited based on age (target 9-14 year olds) and presence (n=70) or absence (n=59) of current asthma. Children wore wrist mounted accelerometers for 6 days and were classified as 'active' if they had ≥60min of moderate-to-vigorous activity (MVA) each day and 'non-active' if they had <60min of MVA on any given day, based on CDC guidelines. Personal BC measured using a MicroAeth, was assessed during two 24-h periods, at the beginning and end of physical activity assessment. High BC was defined as the upper tertile of BC measured with personal sampler. FeNO measurements were sampled at the beginning and end of the of physical activity assessment. Results: In multivariable linear regression models, 'active' children had 25% higher personal BC concentrations (p=0.02) and 20% lower FeNO (p=0.04) compared to 'non-active' children. Among children with high personal BC (n=33), there was no relationship between activity and FeNO (p=1.00). The significant protective relationship between activity and airway inflammation was largely driven by children with lower personal BC (n=96, p=0.04). Conclusions: Children that live in an urban environment and are physically active on a daily basis have higher personal exposure to BC. High BC offsets the protective relationship between physical activity and airway inflammation.
CitationLovinsky-Desir S, Jung KH, Rundle AG, Hoepner LA, Bautista JB, Perera FP, Chillrud SN, Perzanowski MS, Miller RL. Physical activity, black carbon exposure and airway inflammation in an urban adolescent cohort. Environ Res. 2016 Nov;151:756-762. doi: 10.1016/j.envres.2016.09.005. Epub 2016 Sep 29. PMID: 27694044; PMCID: PMC5081133.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Copyright © 2016 Elsevier Inc. All rights reserved.
- Effect of personal exposure to black carbon on changes in allergic asthma gene methylation measured 5 days later in urban children: importance of allergic sensitization.
- Authors: Jung KH, Lovinsky-Desir S, Yan B, Torrone D, Lawrence J, Jezioro JR, Perzanowski M, Perera FP, Chillrud SN, Miller RL
- Issue date: 2017
- Exposure to traffic-related air pollution and changes in exhaled nitric oxide and DNA methylation in arginase and nitric oxide synthase in children with asthma.
- Authors: Ji N, Fang M, Baptista A, Cepeda C, Greenberg M, Mincey IC, Ohman-Strickland P, Haynes F, Fiedler N, Kipen HM, Laumbach RJ
- Issue date: 2021 Feb 11
- Physical activity, black carbon exposure, and DNA methylation in the FOXP3 promoter.
- Authors: Lovinsky-Desir S, Jung KH, Jezioro JR, Torrone DZ, de Planell-Saguer M, Yan B, Perera FP, Rundle AG, Perzanowski MS, Chillrud SN, Miller RL
- Issue date: 2017
- Personal Exposure to Black Carbon at School and Levels of Fractional Exhaled Nitric Oxide in New York City.
- Authors: Jung KH, Goodwin KE, Perzanowski MS, Chillrud SN, Perera FP, Miller RL, Lovinsky-Desir S
- Issue date: 2021 Sep
- Airway oxidative stress and inflammation markers in exhaled breath from children are linked with exposure to black carbon.
- Authors: De Prins S, Dons E, Van Poppel M, Int Panis L, Van de Mieroop E, Nelen V, Cox B, Nawrot TS, Teughels C, Schoeters G, Koppen G
- Issue date: 2014 Dec