Report of prenatal maternal demoralization and material hardship and infant rhinorrhea and watery eyes.
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AuthorConrad, Laura A
Rauh, Virginia A
Hoepner, Lori A
Acosta, Luis M
Perera, Frederica P
Rundle, Andrew G
Miller, Rachel L
Perzanowski, Matthew S
Journal titleAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
Publication Begin page399
Publication End page404.e2
MetadataShow full item record
AbstractBackground: Previously, we found that reported infant rhinorrhea and watery eyes without a cold (RWWC) predicted school age exercise-induced wheezing, emergency department visits, and respiratory-related hospitalizations for asthma. These findings appeared independent of infant wheezing and allergy. Overall, we theorize that prenatal material hardship and psychosocial distress can induce infant dysregulation in the autonomic nervous system leading to infant RWWC and school age exercise-induced wheezing. Objective: To test the hypotheses that indicators of prenatal stress and measures of maternal demoralization, which can alter infant autonomic nervous system responses, would predict infant RWWC. Methods: In a prospective birth cohort of urban children (n = 578), pregnant women were queried in the third trimester about material hardship and maternal demoralization using validated instruments. Child RWWC was queried every 3 months in infancy. Results: Notably, 44% of the mothers reported not being able to afford at least one of the basic needs of daily living during pregnancy, and children of those mothers were more likely to have infant RWWC (P < .001). The children had an increased risk of RWWC with increasing maternal demoralization during pregnancy (P < .001). In models controlling for sex, race and ethnicity, maternal asthma, maternal allergy, smoker in the home (pre- or postnatal), prenatal pesticide exposure, and older siblings, RWWC was predicted by mother's report of material hardship (relative risk, 1.22; P = .021) and maternal demoralization (relative risk, 1.14; P = .030). Conclusion: These results suggest an association between material hardship and psychological distress during pregnancy and RWWC in infancy, further supporting a link between infant autonomic dysregulation and RWWC.
CitationConrad LA, Rauh VA, Hoepner LA, Acosta LM, Perera FP, Rundle AG, Arteaga-Solis E, Miller RL, Perzanowski MS. Report of prenatal maternal demoralization and material hardship and infant rhinorrhea and watery eyes. Ann Allergy Asthma Immunol. 2020 Oct;125(4):399-404.e2. doi: 10.1016/j.anai.2020.07.016. Epub 2020 Jul 22. PMID: 32711029; PMCID: PMC7838563.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Copyright © 2020 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
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