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dc.contributor.authorJack-Roberts, Chauntelle
dc.contributor.authorMaples, Patricia
dc.contributor.authorKalkan, Betul
dc.contributor.authorEdwards, Kaydine
dc.contributor.authorGilboa, Ella
dc.contributor.authorDjuraev, Ikhtiyor
dc.contributor.authorZou, Shuli
dc.contributor.authorHoepner, Lori
dc.contributor.authorFordjour, Lawrence
dc.contributor.authorLee, Wen-Ching
dc.contributor.authorKral, John
dc.contributor.authorDalloul, Mudar
dc.contributor.authorJiang, Xinyin
dc.date.accessioned2022-10-11T15:30:37Z
dc.date.available2022-10-11T15:30:37Z
dc.identifier.citationJack-Roberts C, Maples P, Kalkan B, Edwards K, Gilboa E, Djuraev I, Zou S, Hoepner L, Fordjour L, Lee WC, Kral J, Dalloul M, Jiang X. Gestational diabetes status and dietary intake modify maternal and cord blood allostatic load markers. BMJ Open Diabetes Res Care. 2020 Oct;8(1):e001468. doi: 10.1136/bmjdrc-2020-001468. PMID: 33093129; PMCID: PMC7583070.en_US
dc.identifier.eissn2052-4897
dc.identifier.doi10.1136/bmjdrc-2020-001468
dc.identifier.pmid33093129
dc.identifier.urihttp://hdl.handle.net/20.500.12648/7686
dc.description.abstractIntroduction: Allostatic load (AL) defines cardiometabolic, inflammatory, and neuroendocrine changes in the body in response to internal and external stressors. It is largely unknown whether gestational diabetes mellitus (GDM) alters maternal and fetal AL, which in turn affects GDM outcomes. Whether dietary intakes and quality can modify AL and thus influence GDM progression is also unknown. Research design and methods: In this study, we recruited 35 GDM and 30 non-GDM women in gestational week 25-33. Fasting blood samples were collected at enrollment, and cord venous blood samples were collected at delivery for the measurement of a series of AL biomarkers to calculate the composite AL index. Three-day dietary recalls were conducted at enrollment. Results: Results suggest that GDM women had 60% higher composite AL index scores (p value=0.01). Maternal AL index was associated with shorter duration of gestation (β=-0.33, p value=0.047) and higher fetal AL index (β=0.47, p value=0.006) after adjusting for GDM status. Dietary intake of monounsaturated fatty acids was negatively associated with maternal AL index (β=-0.20, p value=0.006). GDM women had lower total caloric intake and dietary glycemic load, yet their linolenic acid, vitamin C and E intakes were also decreased (all p value<0.05). These dietary differences were not related to birth outcomes measured. Conclusions: In this study, GDM status and dietary intakes modify AL in this population. AL may serve as an indicator of GDM control. Future research on dietary interventions that can improve maternal AL markers during GDM is warranted.en_US
dc.language.isoenen_US
dc.relation.urlhttps://drc.bmj.com/content/8/1/e001468.longen_US
dc.rights© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectdiabetesen_US
dc.subjectdieten_US
dc.subjectgestationalen_US
dc.subjectnutrientsen_US
dc.titleGestational diabetes status and dietary intake modify maternal and cord blood allostatic load markers.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleBMJ open diabetes research & careen_US
dc.source.volume8
dc.source.issue1
dc.source.countryEngland
dc.description.versionVoRen_US
refterms.dateFOA2022-10-11T15:30:37Z
dc.description.institutionSUNY Downstateen_US
dc.description.departmentEnvironmental and Occupational Health Sciencesen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalBMJ open diabetes research & care


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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Except where otherwise noted, this item's license is described as © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.