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dc.contributor.authorHallmark, Brian
dc.contributor.authorWegienka, Ganesa
dc.contributor.authorHavstad, Suzanne
dc.contributor.authorBillheimer, Dean
dc.contributor.authorOwnby, Dennis
dc.contributor.authorMendonca, Eneida A
dc.contributor.authorGress, Lisa
dc.contributor.authorStern, Debra A
dc.contributor.authorMyers, Jocelyn Biagini
dc.contributor.authorKhurana Hershey, Gurjit K
dc.contributor.authorHoepner, Lori
dc.contributor.authorMiller, Rachel L
dc.contributor.authorLemanske, Robert F
dc.contributor.authorJackson, Daniel J
dc.contributor.authorGold, Diane R
dc.contributor.authorO'Connor, George T
dc.contributor.authorNicolae, Dan L
dc.contributor.authorGern, James E
dc.contributor.authorOber, Carole
dc.contributor.authorWright, Anne L
dc.contributor.authorMartinez, Fernando D
dc.date.accessioned2022-10-11T15:24:53Z
dc.date.available2022-10-11T15:24:53Z
dc.identifier.citationHallmark B, Wegienka G, Havstad S, Billheimer D, Ownby D, Mendonca EA, Gress L, Stern DA, Myers JB, Khurana Hershey GK, Hoepner L, Miller RL, Lemanske RF, Jackson DJ, Gold DR, O'Connor GT, Nicolae DL, Gern JE, Ober C, Wright AL, Martinez FD. Chromosome 17q12-21 Variants Are Associated with Multiple Wheezing Phenotypes in Childhood. Am J Respir Crit Care Med. 2021 Apr 1;203(7):864-870. doi: 10.1164/rccm.202003-0820OC. PMID: 33535024; PMCID: PMC8017591.en_US
dc.identifier.eissn1535-4970
dc.identifier.doi10.1164/rccm.202003-0820OC
dc.identifier.pmid33535024
dc.identifier.urihttp://hdl.handle.net/20.500.12648/7685
dc.description.abstractBirth cohort studies have identified several temporal patterns of wheezing, only some of which are associated with asthma. Whether 17q12-21 genetic variants, which are closely associated with asthma, are also associated with childhood wheezing phenotypes remains poorly explored. To determine whether wheezing phenotypes, defined by latent class analysis (LCA), are associated with nine 17q12-21 SNPs and if so, whether these relationships differ by race/ancestry. Data from seven U.S. birth cohorts ( = 3,786) from the CREW (Children's Respiratory Research and Environment Workgroup) were harmonized to represent whether subjects wheezed in each year of life from birth until age 11 years. LCA was then performed to identify wheeze phenotypes. Genetic associations between SNPs and wheeze phenotypes were assessed separately in European American (EA) ( = 1,308) and, for the first time, in African American (AA) ( = 620) children. The LCA best supported four latent classes of wheeze: infrequent, transient, late-onset, and persistent. Odds of belonging to any of the three wheezing classes (vs. infrequent) increased with the risk alleles for multiple SNPs in EA children. Only one SNP, rs2305480, showed increased odds of belonging to any wheezing class in both AA and EA children. These results indicate that 17q12-21 is a "wheezing locus," and this association may reflect an early life susceptibility to respiratory viruses common to all wheezing children. Which children will have their symptoms remit or reoccur during childhood may be independent of the influence of rs2305480.en_US
dc.language.isoenen_US
dc.relation.urlhttps://www.atsjournals.org/doi/10.1164/rccm.202003-0820OCen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject17q12-21en_US
dc.subjectasthmaen_US
dc.subjectgeneticsen_US
dc.subjectlatent class analysisen_US
dc.subjectwheezeen_US
dc.titleChromosome 17q12-21 Variants Are Associated with Multiple Wheezing Phenotypes in Childhood.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleAmerican journal of respiratory and critical care medicineen_US
dc.source.volume203
dc.source.issue7
dc.source.beginpage864
dc.source.endpage870
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.description.versionVoRen_US
refterms.dateFOA2022-10-11T15:24:54Z
dc.description.institutionSUNY Downstateen_US
dc.description.departmentEnvironmental and Occupational Health Sciencesen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalAmerican journal of respiratory and critical care medicine


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