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dc.contributor.authorHeindel, Jerrold J
dc.contributor.authorHoward, Sarah
dc.contributor.authorAgay-Shay, Keren
dc.contributor.authorArrebola, Juan P
dc.contributor.authorAudouze, Karine
dc.contributor.authorBabin, Patrick J
dc.contributor.authorBarouki, Robert
dc.contributor.authorBansal, Amita
dc.contributor.authorBlanc, Etienne
dc.contributor.authorCave, Matthew C
dc.contributor.authorChatterjee, Saurabh
dc.contributor.authorChevalier, Nicolas
dc.contributor.authorChoudhury, Mahua
dc.contributor.authorCollier, David
dc.contributor.authorConnolly, Lisa
dc.contributor.authorCoumoul, Xavier
dc.contributor.authorGarruti, Gabriella
dc.contributor.authorGilbertson, Michael
dc.contributor.authorHoepner, Lori A
dc.contributor.authorHolloway, Alison C
dc.contributor.authorHowell, George
dc.contributor.authorKassotis, Christopher D
dc.contributor.authorKay, Mathew K
dc.contributor.authorKim, Min Ji
dc.contributor.authorLagadic-Gossmann, Dominique
dc.contributor.authorLangouet, Sophie
dc.contributor.authorLegrand, Antoine
dc.contributor.authorLi, Zhuorui
dc.contributor.authorLe Mentec, Helene
dc.contributor.authorLind, Lars
dc.contributor.authorMonica Lind, P
dc.contributor.authorLustig, Robert H
dc.contributor.authorMartin-Chouly, Corinne
dc.contributor.authorMunic Kos, Vesna
dc.contributor.authorPodechard, Normand
dc.contributor.authorRoepke, Troy A
dc.contributor.authorSargis, Robert M
dc.contributor.authorStarling, Anne
dc.contributor.authorTomlinson, Craig R
dc.contributor.authorTouma, Charbel
dc.contributor.authorVondracek, Jan
dc.contributor.authorVom Saal, Frederick
dc.contributor.authorBlumberg, Bruce
dc.date.accessioned2022-10-11T15:14:06Z
dc.date.available2022-10-11T15:14:06Z
dc.date.issued2022-04-05
dc.identifier.citationHeindel JJ, Howard S, Agay-Shay K, Arrebola JP, Audouze K, Babin PJ, Barouki R, Bansal A, Blanc E, Cave MC, Chatterjee S, Chevalier N, Choudhury M, Collier D, Connolly L, Coumoul X, Garruti G, Gilbertson M, Hoepner LA, Holloway AC, Howell G 3rd, Kassotis CD, Kay MK, Kim MJ, Lagadic-Gossmann D, Langouet S, Legrand A, Li Z, Le Mentec H, Lind L, Monica Lind P, Lustig RH, Martin-Chouly C, Munic Kos V, Podechard N, Roepke TA, Sargis RM, Starling A, Tomlinson CR, Touma C, Vondracek J, Vom Saal F, Blumberg B. Obesity II: Establishing causal links between chemical exposures and obesity. Biochem Pharmacol. 2022 May;199:115015. doi: 10.1016/j.bcp.2022.115015. Epub 2022 Apr 5. Erratum in: Biochem Pharmacol. 2022 Aug;202:115144. PMID: 35395240; PMCID: PMC9124454.en_US
dc.identifier.eissn1873-2968
dc.identifier.doi10.1016/j.bcp.2022.115015
dc.identifier.pmid35395240
dc.identifier.urihttp://hdl.handle.net/20.500.12648/7683
dc.description.abstractObesity is a multifactorial disease with both genetic and environmental components. The prevailing view is that obesity results from an imbalance between energy intake and expenditure caused by overeating and insufficient exercise. We describe another environmental element that can alter the balance between energy intake and energy expenditure: obesogens. Obesogens are a subset of environmental chemicals that act as endocrine disruptors affecting metabolic endpoints. The obesogen hypothesis posits that exposure to endocrine disruptors and other chemicals can alter the development and function of the adipose tissue, liver, pancreas, gastrointestinal tract, and brain, thus changing the set point for control of metabolism. Obesogens can determine how much food is needed to maintain homeostasis and thereby increase the susceptibility to obesity. The most sensitive time for obesogen action is in utero and early childhood, in part via epigenetic programming that can be transmitted to future generations. This review explores the evidence supporting the obesogen hypothesis and highlights knowledge gaps that have prevented widespread acceptance as a contributor to the obesity pandemic. Critically, the obesogen hypothesis changes the narrative from curing obesity to preventing obesity.en_US
dc.language.isoenen_US
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/S0006295222001095en_US
dc.rightsCopyright © 2022 Elsevier Inc. All rights reserved.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAdipocyte differentiationen_US
dc.subjectEndocrine disruptoren_US
dc.subjectObesityen_US
dc.subjectObesogenen_US
dc.subjectWeight gainen_US
dc.titleObesity II: Establishing causal links between chemical exposures and obesity.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleBiochemical pharmacologyen_US
dc.source.volume199
dc.source.beginpage115015
dc.source.endpage
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryCanada
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryEngland
dc.description.versionVoRen_US
refterms.dateFOA2022-10-11T15:14:06Z
dc.description.institutionSUNY Downstateen_US
dc.description.departmentEnvironmental and Occupational Health Sciencesen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalBiochemical pharmacology


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Copyright © 2022 Elsevier Inc. All rights reserved.
Except where otherwise noted, this item's license is described as Copyright © 2022 Elsevier Inc. All rights reserved.