Obesity II: Establishing causal links between chemical exposures and obesity.
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AuthorHeindel, Jerrold J
Arrebola, Juan P
Babin, Patrick J
Cave, Matthew C
Hoepner, Lori A
Holloway, Alison C
Kassotis, Christopher D
Kay, Mathew K
Kim, Min Ji
Le Mentec, Helene
Monica Lind, P
Lustig, Robert H
Munic Kos, Vesna
Roepke, Troy A
Sargis, Robert M
Tomlinson, Craig R
Vom Saal, Frederick
Journal titleBiochemical pharmacology
Publication Begin page115015
MetadataShow full item record
AbstractObesity is a multifactorial disease with both genetic and environmental components. The prevailing view is that obesity results from an imbalance between energy intake and expenditure caused by overeating and insufficient exercise. We describe another environmental element that can alter the balance between energy intake and energy expenditure: obesogens. Obesogens are a subset of environmental chemicals that act as endocrine disruptors affecting metabolic endpoints. The obesogen hypothesis posits that exposure to endocrine disruptors and other chemicals can alter the development and function of the adipose tissue, liver, pancreas, gastrointestinal tract, and brain, thus changing the set point for control of metabolism. Obesogens can determine how much food is needed to maintain homeostasis and thereby increase the susceptibility to obesity. The most sensitive time for obesogen action is in utero and early childhood, in part via epigenetic programming that can be transmitted to future generations. This review explores the evidence supporting the obesogen hypothesis and highlights knowledge gaps that have prevented widespread acceptance as a contributor to the obesity pandemic. Critically, the obesogen hypothesis changes the narrative from curing obesity to preventing obesity.
CitationHeindel JJ, Howard S, Agay-Shay K, Arrebola JP, Audouze K, Babin PJ, Barouki R, Bansal A, Blanc E, Cave MC, Chatterjee S, Chevalier N, Choudhury M, Collier D, Connolly L, Coumoul X, Garruti G, Gilbertson M, Hoepner LA, Holloway AC, Howell G 3rd, Kassotis CD, Kay MK, Kim MJ, Lagadic-Gossmann D, Langouet S, Legrand A, Li Z, Le Mentec H, Lind L, Monica Lind P, Lustig RH, Martin-Chouly C, Munic Kos V, Podechard N, Roepke TA, Sargis RM, Starling A, Tomlinson CR, Touma C, Vondracek J, Vom Saal F, Blumberg B. Obesity II: Establishing causal links between chemical exposures and obesity. Biochem Pharmacol. 2022 May;199:115015. doi: 10.1016/j.bcp.2022.115015. Epub 2022 Apr 5. Erratum in: Biochem Pharmacol. 2022 Aug;202:115144. PMID: 35395240; PMCID: PMC9124454.
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Except where otherwise noted, this item's license is described as Copyright © 2022 Elsevier Inc. All rights reserved.
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