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dc.contributor.authorKupsco, Allison
dc.contributor.authorSjödin, Andreas
dc.contributor.authorCowell, Whitney
dc.contributor.authorJones, Richard
dc.contributor.authorOberfield, Sharon
dc.contributor.authorWang, Shuang
dc.contributor.authorHoepner, Lori A
dc.contributor.authorGallagher, Dympna
dc.contributor.authorBaccarelli, Andrea A
dc.contributor.authorGoldsmith, Jeff
dc.contributor.authorRundle, Andrew G
dc.contributor.authorHerbstman, Julie B
dc.date.accessioned2022-10-11T14:47:03Z
dc.date.available2022-10-11T14:47:03Z
dc.date.issued2022-09-08
dc.identifier.citationKupsco A, Sjödin A, Cowell W, Jones R, Oberfield S, Wang S, Hoepner LA, Gallagher D, Baccarelli AA, Goldsmith J, Rundle AG, Herbstman JB. Prenatal exposure to polybrominated diphenyl ethers and BMI Z-scores from 5 to 14 years. Environ Health. 2022 Sep 8;21(1):82. doi: 10.1186/s12940-022-00893-5. PMID: 36076289; PMCID: PMC9454187.en_US
dc.identifier.eissn1476-069X
dc.identifier.doi10.1186/s12940-022-00893-5
dc.identifier.pmid36076289
dc.identifier.urihttp://hdl.handle.net/20.500.12648/7679
dc.description.abstractBackground: Polybrominated diphenyl ethers (PBDEs) are flame-retardant compounds widely used in household products until phase out in 2004. PBDEs are endocrine disruptors and are suggested to influence signaling related to weight control. Prenatal exposures to PBDEs may alter childhood adiposity, yet few studies have examined these associations in human populations. Methods: Data were collected from a birth cohort of Dominican and African American mother-child pairs from New York City recruited from 1998 to 2006. PBDE congeners BDE-47, - 99, - 100, and - 153 were measured in cord plasma (ng/μL) and dichotomized into low (< 80th percentile) and high (>80th percentile) exposure categories. Height and weight were collected at ages 5, 7, 9, 11, and an ancillary visit from 8 to 14 years (n = 289). Mixed-effects models with random intercepts for participant were used to assess associations between concentrations of individual PBDE congeners or the PBDE sum and child BMI z-scores (BMIz). To assess associations between PBDEs and the change in BMIz over time, models including interactions between PBDE categories and child age and (child age)2 were fit. Quantile g-computation was used to investigate associations between BMIz and the total PBDE mixture. Models were adjusted for baseline maternal covariates: ethnicity, age, education, parity, partnership status, and receipt of public assistance, and child covariates: child sex and cord cholesterol and triglycerides. Results: The prevalence of children with obesity at age 5 was 24.2% and increased to 30% at age 11. Neither cord levels of individual PBDEs nor the total PBDE mixture were associated with overall BMIz in childhood. The changes in BMIz across childhood were not different between children with low or high PBDEs. Results were similar when adjusting for postnatal PBDE exposures. Conclusions: Prenatal PBDE exposures were not associated with child growth trajectories in a cohort of Dominican and African American children.en_US
dc.language.isoenen_US
dc.relation.urlhttps://ehjournal.biomedcentral.com/articles/10.1186/s12940-022-00893-5en_US
dc.rights© 2022. The Author(s).
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAdiposityen_US
dc.subjectBMIen_US
dc.subjectPBDEsen_US
dc.subjectPolybrominated diphenyl ethersen_US
dc.subjectPrenatal exposuresen_US
dc.subjectchildren’s environmental healthen_US
dc.titlePrenatal exposure to polybrominated diphenyl ethers and BMI Z-scores from 5 to 14 years.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleEnvironmental health : a global access science sourceen_US
dc.source.volume21
dc.source.issue1
dc.source.beginpage82
dc.source.endpage
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryEngland
dc.description.versionVoRen_US
refterms.dateFOA2022-10-11T14:47:04Z
dc.description.institutionSUNY Downstateen_US
dc.description.departmentEnvironmental and Occupational Health Sciencesen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalEnvironmental health : a global access science source


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