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dc.contributor.authorBohr, Tomas
dc.contributor.authorHjorth, Poul G
dc.contributor.authorHolst, Sebastian C
dc.contributor.authorHrabětová, Sabina
dc.contributor.authorKiviniemi, Vesa
dc.contributor.authorLilius, Tuomas
dc.contributor.authorLundgaard, Iben
dc.contributor.authorMardal, Kent-Andre
dc.contributor.authorMartens, Erik A
dc.contributor.authorMori, Yuki
dc.contributor.authorNägerl, U Valentin
dc.contributor.authorNicholson, Charles
dc.contributor.authorTannenbaum, Allen
dc.contributor.authorThomas, John H
dc.contributor.authorTithof, Jeffrey
dc.contributor.authorBenveniste, Helene
dc.contributor.authorIliff, Jeffrey J
dc.contributor.authorKelley, Douglas H
dc.contributor.authorNedergaard, Maiken
dc.date.accessioned2022-09-22T15:11:44Z
dc.date.available2022-09-22T15:11:44Z
dc.date.issued2022-08-20
dc.identifier.citationBohr T, Hjorth PG, Holst SC, Hrabětová S, Kiviniemi V, Lilius T, Lundgaard I, Mardal KA, Martens EA, Mori Y, Nägerl UV, Nicholson C, Tannenbaum A, Thomas JH, Tithof J, Benveniste H, Iliff JJ, Kelley DH, Nedergaard M. The glymphatic system: Current understanding and modeling. iScience. 2022 Aug 20;25(9):104987. doi: 10.1016/j.isci.2022.104987. PMID: 36093063; PMCID: PMC9460186.en_US
dc.identifier.eissn2589-0042
dc.identifier.doi10.1016/j.isci.2022.104987
dc.identifier.pmid36093063
dc.identifier.urihttp://hdl.handle.net/20.500.12648/7561
dc.description.abstractWe review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, stroke, cardiac arrest, and neurodegenerative disorders like Alzheimer's disease. We sort existing models into broad categories by anatomical function: Perivascular flow, transport in brain parenchyma, interfaces to perivascular spaces, efflux routes, and links to neuronal activity. Needs and opportunities for future work are highlighted wherever possible; new models, expanded models, and novel experiments to inform models could all have tremendous value for advancing the field.en_US
dc.language.isoenen_US
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/S2589004222012597?via%3Dihuben_US
dc.rights© 2022 The Author(s).
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectNeuroanatomyen_US
dc.subjectNeuroscienceen_US
dc.subjectSystems biologyen_US
dc.titleThe glymphatic system: Current understanding and modeling.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleiScienceen_US
dc.source.volume25
dc.source.issue9
dc.source.beginpage104987
dc.source.endpage
dc.source.countryUnited States
dc.description.versionVoRen_US
refterms.dateFOA2022-09-22T15:11:45Z
dc.description.institutionSUNY Downstateen_US
dc.description.departmentCell Biologyen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journaliScience


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