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dc.contributor.authorTsangaras, Kyriakos
dc.contributor.authorKolokotronis, Sergios-Orestis
dc.contributor.authorUlrich, Rainer G.
dc.contributor.authorMorand, Serge
dc.contributor.authorMichaux, Johan
dc.contributor.authorGreenwood, Alex D.
dc.date.accessioned2022-08-25T19:11:18Z
dc.date.available2022-08-25T19:11:18Z
dc.date.issued2014-07-20
dc.identifier.citationTsangaras K, Kolokotronis SO, Ulrich RG, Morand S, Michaux J, Greenwood AD. Negative purifying selection drives prion and doppel protein evolution. J Mol Evol. 2014 Aug;79(1-2):12-20. doi: 10.1007/s00239-014-9632-1. Epub 2014 Jul 20. PMID: 25038839.en_US
dc.identifier.issn0022-2844
dc.identifier.eissn1432-1432
dc.identifier.doi10.1007/s00239-014-9632-1
dc.identifier.pmid25038839
dc.identifier.pii9632
dc.identifier.urihttp://hdl.handle.net/20.500.12648/7511
dc.description.abstractThe prion protein (PrP) when misfolded into the pathogenic conformer PrP(Sc) is the major causative agent of several lethal transmissible spongiform encephalopathies in mammals. Studies of evolutionary pressure on the corresponding gene using different datasets have yielded conflicting results. In addition, putative PrP or PrP interacting partners with strong similarity to PrP such as the doppel protein have not been examined to determine if the same evolutionary mechanisms apply to prion paralogs or if there are coselected sites that might indicate how and where the proteins interact. We examined several taxonomic groups that contain model organisms of prion diseases focusing on primates, bovids, and an expanded dataset of rodents for selection pressure on the prion gene (PRNP) and doppel gene (PRND) individually and for coevolving sites within. Overall, the results clearly indicate that both proteins are under strong selective constraints with relaxed selection on amino acid residues connecting α-helices 1 and 2.en_US
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media LLCen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://www.springer.com/tdm
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectGeneticsen_US
dc.subjectMolecular Biologyen_US
dc.subjectEcology, Evolution, Behavior and Systematicsen_US
dc.titleNegative Purifying Selection Drives Prion and Doppel Protein Evolutionen_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleJournal of Molecular Evolutionen_US
dc.source.volume79
dc.source.issue1-2
dc.source.beginpage12
dc.source.endpage20
dc.description.versionVoRen_US
refterms.dateFOA2022-08-25T19:11:19Z
dc.description.institutionSUNY Downstateen_US
dc.description.departmentEpidemiology and Biostatisticsen_US
dc.description.degreelevelN/Aen_US


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