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dc.contributor.authorPlanet, Paul J.
dc.contributor.authorDiaz, Lorena
dc.contributor.authorKolokotronis, Sergios-Orestis
dc.contributor.authorNarechania, Apurva
dc.contributor.authorReyes, Jinnethe
dc.contributor.authorXing, Galen
dc.contributor.authorRincon, Sandra
dc.contributor.authorSmith, Hannah
dc.contributor.authorPanesso, Diana
dc.contributor.authorRyan, Chanelle
dc.contributor.authorSmith, Dylan P.
dc.contributor.authorGuzman, Manuel
dc.contributor.authorZurita, Jeannete
dc.contributor.authorSebra, Robert
dc.contributor.authorDeikus, Gintaras
dc.contributor.authorNolan, Rathel L.
dc.contributor.authorTenover, Fred C.
dc.contributor.authorWeinstock, George M.
dc.contributor.authorRobinson, D. Ashley
dc.contributor.authorArias, Cesar A.
dc.date.accessioned2022-08-25T18:34:04Z
dc.date.available2022-08-25T18:34:04Z
dc.date.issued2015-06-05
dc.identifier.citationPlanet PJ, Diaz L, Kolokotronis SO, Narechania A, Reyes J, Xing G, Rincon S, Smith H, Panesso D, Ryan C, Smith DP, Guzman M, Zurita J, Sebra R, Deikus G, Nolan RL, Tenover FC, Weinstock GM, Robinson DA, Arias CA. Parallel Epidemics of Community-Associated Methicillin-Resistant Staphylococcus aureus USA300 Infection in North and South America. J Infect Dis. 2015 Dec 15;212(12):1874-82. doi: 10.1093/infdis/jiv320. Epub 2015 Jun 5. PMID: 26048971; PMCID: PMC4655856.en_US
dc.identifier.issn0022-1899
dc.identifier.eissn1537-6613
dc.identifier.doi10.1093/infdis/jiv320
dc.identifier.pmid26048971
dc.identifier.pii10.1093/infdis/jiv320
dc.identifier.urihttp://hdl.handle.net/20.500.12648/7503
dc.description.abstractBackground: The community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) epidemic in the United States is attributed to the spread of the USA300 clone. An epidemic of CA-MRSA closely related to USA300 has occurred in northern South America (USA300 Latin-American variant, USA300-LV). Using phylogenomic analysis, we aimed to understand the relationships between these 2 epidemics. Methods: We sequenced the genomes of 51 MRSA clinical isolates collected between 1999 and 2012 from the United States, Colombia, Venezuela, and Ecuador. Phylogenetic analysis was used to infer the relationships and times since the divergence of the major clades. Results: Phylogenetic analyses revealed 2 dominant clades that segregated by geographical region, had a putative common ancestor in 1975, and originated in 1989, in North America, and in 1985, in South America. Emergence of these parallel epidemics coincides with the independent acquisition of the arginine catabolic mobile element (ACME) in North American isolates and a novel copper and mercury resistance (COMER) mobile element in South American isolates. Conclusions: Our results reveal the existence of 2 parallel USA300 epidemics that shared a recent common ancestor. The simultaneous rapid dissemination of these 2 epidemic clades suggests the presence of shared, potentially convergent adaptations that enhance fitness and ability to spread.en_US
dc.description.sponsorshipNational Institute of Allergy and Infectious Diseasesen_US
dc.language.isoenen_US
dc.publisherOxford University Press (OUP)en_US
dc.relation.urlhttps://academic.oup.com/jid/article/212/12/1874/2911927en_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectInfectious Diseasesen_US
dc.subjectImmunology and Allergyen_US
dc.subjectMRSAen_US
dc.subjectUSA300en_US
dc.subjectUSA300-LVen_US
dc.subjectepidemicsen_US
dc.titleParallel Epidemics of Community-Associated Methicillin-Resistant<i>Staphylococcus aureus</i>USA300 Infection in North and South Americaen_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleJournal of Infectious Diseasesen_US
dc.source.volume212
dc.source.issue12
dc.source.beginpage1874
dc.source.endpage1882
dc.description.versionVoRen_US
refterms.dateFOA2022-08-25T18:34:04Z
dc.description.institutionSUNY Downstateen_US
dc.description.departmentEpidemiology and Biostatisticsen_US
dc.description.degreelevelN/Aen_US


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International