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    Role of Phytoestrogens in Cancer Therapy

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    Author
    Virk-Baker, Mandeep
    Nagy, Tim R.
    Barnes, Stephen
    Keyword
    Phytoestrogens
    Cancer therapy
    Cell cycle regulation
    Inflammation
    Angiogenesis
    Metastasis
    Journal title
    Planta Medica
    Date Published
    2010
    
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    URI
    http://hdl.handle.net/20.500.12648/7394
    Abstract
    Cancer is a leading cause of death worldwide, and the numbers of new cancer cases are expected to continue to rise. The main goals of cancer therapy include removing the primary tumor, preventing the spread of distant metastases, and improving survival and quality of life for the patients. To attain these goals of cancer therapy, the combination of different chemotherapeutics, as opposed to the conventional single-agent treatment, is an emerging area of research. Given the potential risks of drug toxicity in such treatment, the focus is to have a second compound that increases the anticancer potential of the primary agent but which reduces toxicity. There is an ever growing interest in treatment with natural compounds, such as plant phytoestrogens, as an adjuvant cancer therapy along with conventional cancer therapy. The question remains whether or not adding these compounds to the cancer therapy regimen as a second agent would be beneficial, and if they are safe to be used among cancer patients. The current literature suggests that phytoestrogen treatment is capable of inducing G2/M cell cycle arrest in a number of cancer cell lines, as well as upregulating cell cycle inhibitory molecules. Phytoestrogen therapy has been shown to inhibit inflammation, angiogenesis and metastases in various in vivo tumor models, and pronounced benefits have been observed when combined with radiation therapy. The lack of side effects from phase I and II clinical trials of phytoestrogens in cancer therapy points towards their safety, but to further understand their added benefit clinical studies with large sample sizes are required. We have reviewed the recent research studies in these areas in an attempt to find evidence for their role in cancer therapy as well as safety.
    Citation
    Virk-Baker MK, Nagy TR, Barnes S. Role of phytoestrogens in cancer therapy. Planta Med. 2010 Aug;76(11):1132-42. doi: 10.1055/s-0030-1250074. Epub 2010 Jul 1. PMID: 20597043; PMCID: PMC3800092.
    DOI
    10.1055/s-0030-1250074
    Description
    Electronic Accessibility Statement: SUNY Oneonta is committed to providing equal access to college information by ensuring our digital content is accessible by everyone regardless of physical, sensory, or cognitive ability. This item has been checked by Adobe Acrobat Accessibility Check and remediated with the following result: [Remediation: title, tagged, reading order / Hazards: alt text, table headers and regularity]. To request further accessibility remediation on this SOAR repository item for your specific needs, please contact openaccess@oneonta.edu.
    ae974a485f413a2113503eed53cd6c53
    10.1055/s-0030-1250074
    Scopus Count
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    School of Education, Human Ecology & Sports Studies - Scholarly and Creative Works
    SUNY Oneonta Scholarly and Creative Works

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