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dc.contributor.authorWang, Shi-Heng
dc.contributor.authorHsiao, Po-Chang
dc.contributor.authorYeh, Ling-Ling
dc.contributor.authorLiu, Chih-Min
dc.contributor.authorLiu, Chen-Chung
dc.contributor.authorHwang, Tzung-Jeng
dc.contributor.authorHsieh, Ming H.
dc.contributor.authorChien, Yi-Ling
dc.contributor.authorLin, Yi-Ting
dc.contributor.authorHuang, Yen-Tsung
dc.contributor.authorChen, Chia-Yen
dc.contributor.authorChandler, Sharon D.
dc.contributor.authorFaraone, Stephen V.
dc.contributor.authorNeale, Benjamin
dc.contributor.authorGlatt, Stephen J.
dc.contributor.authorTsuang, Ming T.
dc.contributor.authorHwu, Hai-Gwo
dc.contributor.authorChen, Wei J.
dc.date.accessioned2021-10-26T14:33:16Z
dc.date.available2021-10-26T14:33:16Z
dc.date.issued2019-07
dc.identifier.issn0006-3223
dc.identifier.doi10.1016/j.biopsych.2019.01.023
dc.identifier.piiS0006322319300691
dc.identifier.urihttp://hdl.handle.net/20.500.12648/7004
dc.description.abstractBACKGROUND:Whether paternal age effect on schizophrenia is a causation or just an association due to con-founding by selection into late parenthood is still debated. We investigated the association between paternal age andearly onset of schizophrenia in offspring, controlling for both paternal and maternal predisposition to schizophrenia asempirically estimated using polygenic risk score (PRS) derived from the Psychiatric Genomics Consortium.METHODS:Among 2923 sporadic schizophrenia cases selected from the Schizophrenia Trio Genomic Research inTaiwan project, 1649 had parents’genotyping data. The relationships of paternal schizophrenia PRS to paternal ageatfirst birth (AFB) and of maternal schizophrenia PRS to maternal AFB were examined. A logistic regression model ofpatients’early onset of schizophrenia (#18 years old) on paternal age was conducted.RESULTS:Advanced paternal age over 20 years exhibited a trend of an increasing proportion of early onset ofschizophrenia (odds ratio per 10-year increase in paternal age = 1.28,p= .007) after adjusting for maternal age, sex,and age. Older paternal AFB also exhibited an increasing trend of paternal schizophrenia PRS. Additionally, aU-shaped relationship between maternal AFB and maternal schizophrenia PRS was observed. After adjusting forboth paternal and maternal schizophrenia PRS, the association of paternal age with patients’early onset ofschizophrenia remained (odds ratio = 1.29,p= .04).CONCLUSIONS:The association between paternal age and early onset of schizophrenia was not confounded byparental PRS for schizophrenia, which partially captures parental genetic vulnerability to schizophrenia. Ourfindingssupport an independent role of paternal age per se in increased risk of early onset of schizophrenia in offspringen_US
dc.description.sponsorshipTaiwan National Health Research Institutesen_US
dc.language.isoenen_US
dc.publisherElsevier BVen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttps://www.elsevier.com/tdm/userlicense/1.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBiological Psychiatryen_US
dc.subjectDe novo mutation, GWAS, Paternal age, Polygenic risk score, Schizophrenia, Selection into latefatherhooden_US
dc.titleAdvanced Paternal Age and Early Onset of Schizophrenia in Sporadic Cases: Not Confounded by Parental Polygenic Risk for Schizophreniaen_US
dc.typeArticleen_US
dc.source.journaltitleBiological Psychiatryen_US
dc.source.volume86
dc.source.issue1
dc.source.beginpage56
dc.source.endpage64
dc.description.versionAMen_US
refterms.dateFOA2020-07-30T00:00:00Z
dc.description.institutionUpstate Medical Universityen_US
dc.description.departmentPsychiatryen_US
dc.description.degreelevelN/Aen_US


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