Six-week, double-blind, placebo-controlled study of desipramine for adult attention deficit hyperactivity disorder
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Author
Wilen, T EBiederman, J
Prince, J
spencer, T J
Faraone, Stephen V.
Warburton, R
Schleifer, D
Harding, M
Linehan, C
Geller, D
Keyword
Psychiatry and Mental healthJournal title
American Journal of PsychiatryDate Published
1996-09Publication Volume
153Publication Issue
9Publication Begin page
1147Publication End page
1153
Metadata
Show full item recordAbstract
O bjective: The factor structures of individual positive and negative symptoms as well as global ratings were examined in a diagnostically heterogeneous group of subjects. Method: Subjects were identified through a clinical and family study of patients with major psychoses at a VA medical center and evaluated with the Scale for the Assessment of N egative Symptoms and the Scale for the Assessment of Positive Symptoms. For the examination of global-level factor structures (N =630), both principal-component analysis and factor analysis with orthogonal rotation were used. Factor analysis was used for the examination of item-level factor structures as well (N =549). Results: The principal-component analysis of global ratings revealed three factors: negative symptoms, positive symptoms, and disorganization. The factor analysis of global ratings revealed a negative symptom factor and a positive symptom factor. The itemlevel factor analysis revealed two negative symptom factors (diminished expression and disordered relating), two positive symptom factors (bizarre delusions and auditory hallucinations), and a disorganization factor. Conclusions: The generation of additional meaningful factors at the item level suggests that important information about symptoms is lost when only global ratings are viewed. Future work should explore clinical and pathological correlates of the more differentiated item-level symptom dimensionsDOI
10.1176/ajp.153.9.1147ae974a485f413a2113503eed53cd6c53
10.1176/ajp.153.9.1147
Scopus Count
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International