• Login
    View Item 
    •   Home
    • University Colleges
    • SUNY Brockport
    • Theses
    • Senior Honors Theses
    • View Item
    •   Home
    • University Colleges
    • SUNY Brockport
    • Theses
    • Senior Honors Theses
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of SUNY Open Access RepositoryCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Campus Communities in SOAR

    BrockportCantonDownstateEmpireFashion Institute of TechnologyFredoniaMaritimeNew PaltzOneontaOptometryOswegoPlattsburghSUNY Polytechnic InstituteSUNY PressUpstate Medical

    Statistics

    Display statistics

    Effects of Magnesium Deprivation on the Flora of the Gastrointestinal Tract

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    honors/238/fulltext (1).pdf
    Size:
    236.4Kb
    Format:
    PDF
    Download
    Average rating
     
       votes
    Cast your vote
    You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
    Star rating
     
    Your vote was cast
    Thank you for your feedback
    Author
    Cooke, Tricia
    Keyword
    Cohn's Disease
    Gastrointestinal (GI) Inflammation
    Black-6 Mice
    Mg2+ Deficiency
    Date Published
    2018-05-15
    
    Metadata
    Show full item record
    URI
    http://hdl.handle.net/20.500.12648/6727
    Abstract
    Crohn’s disease, a pathological condition characterized by gastrointestinal (GI) inflammation and mucosal changes is often associated with hypomagnesemia resulting from changes in the GI mucosa and an increased GI transit rate. Furthermore, certain types of bacteria are also implicated in the formation of GI neoplasia and carcinogenesis. A variety of physiologic changes such as an increase in the systemic stress response, severity of the inflammatory response, or an exaggerated immune response is known to occur in Magnesium (Mg2+) deficient mice and rats. To understand to what extent Mg2+ deficiency could contribute to the aggravation of such diseases by inducing specific changes in the GI microbiome, this study will focus on the effect of a Mg2+ deficient diet on the GI flora of Black-6 mice. Mice were fed diets containing known concentrations of Mg2+ for 1 week before being placed in a metabolic cage for 24 hours. After 24 hours the mice were sacrificed, blood, feces, and urine samples were collected, and total food consumption, urine excretion and feces excretion was determined. Bacterial analysis of feces, collected via dissection of the colon, revealed that a decrease in the amount of dietary Mg2+ consumed is associated with an increase in the number of Lactic Acid Bacteria (LAB) and Bifidobacterium Colony-Forming Units (CFU) found per gram of feces. Based on the average amount of Mg2+ excreted in the feces and urine of the mice on each diet (Regular, 2% Mg oxide, 2% Mg citrate, 1% Mg citrate, 0.5% Mg citrate, or Mg free) it was also determined that the Mg2+ in the 2% Mg citrate diet is absorbed into systemic circulation more efficiently than the Mg2+ in the other diets tested. Further research is still required to determine if the changes in GI flora associated with a lower dietary Mg2+ consumption are due to systemic hypomagnesemia or due to decreased luminal availability of Mg2+ in the GI tract, but based on the results of this study, it can be concluded that decreased dietary Magnesium consumption has a notable effect on the flora of the GI tract.
    Collections
    Senior Honors Theses

    entitlement

     

    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.