Show simple item record

dc.contributor.advisorPelletier, Michel
dc.contributor.authorFlint, Alexandra
dc.date.accessioned2021-09-08T14:16:35Z
dc.date.available2021-09-08T14:16:35Z
dc.date.issued5/4/2018
dc.identifier.urihttp://hdl.handle.net/20.500.12648/6705
dc.description.abstractPhospholipids biosynthesis, particularly phosphatidylcholine (PC) and phosphatidylethanolamine (PE) plays a major role in the survival of T.brucei. Of great importance is the fact that, as opposed to other parasitic organisms, trypanosomes synthesize phospholipids de novo. Although the pathways for phospholipids biosynthesis have not been very well characterized, recent data have helped to better understand how trypanosomes are able to assemble phospholipids. Previous work in our lab has shown that a protein, termed TbLpn, is a phosphatidic acid phosphatase potentially involved in phospholipid biosynthesis in T.brucei. In addition, TbLpn contains methylated arginine residues and interacts with T.brucei major Protein Arginine Methyltransferases, TbPRMT7. The major focus of my project is to identify the effect of TbLpn methylation by TbPRMT7 on its enzymatic activity and cellular localization.
dc.subjectTrypansoma Brucei
dc.subjectAfrican Sleeping Sickness
dc.subjectTsetse Fly
dc.subjectPhospholipids Biosynthesis
dc.titleArginine Methylation of TbLpn, a Trypanosome Lipin Homologue, by TbPRMT Enzymes
dc.typethesis
refterms.dateFOA2021-09-08T14:16:35Z
dc.description.institutionSUNY Brockport
dc.description.departmentBiology
dc.source.statuspublished
dc.description.publicationtitleSenior Honors Theses
dc.contributor.organizationThe College at Brockport
dc.languate.isoen_US


Files in this item

Thumbnail
Name:
honors/219/fulltext (1).pdf
Size:
1.183Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record