• Further evidence of an association between maternal smoking during pregnancy and attention deficit hyperactivity disorder: Findings from a high-risk sample of siblings

      Milberger, Sharon; Biederman, Joseph; Faraone, Stephen V.; Jones, Janice (Informa UK Limited, 1998-09)
      The authors investigated the relationship between attentiondeficit/byperactivity disorder (ADHD) and cigarette smoking in siblings of ADHD and non-ADHD probands. They conducted a 4-year follow-up of siblings from ADHD and control-group families. In the siblings of ADHD probands, ADHD was associated with higher rates and earlier onset of cigarette smoking. There was also a significant positive association between cigarette smoking and conduct disorder, major depression, and drug abuse in the siblings, even after adjusting for confounding variables. Moreover, smoking was found to be familial among ADHD families but not control-group families. Our findings indicate that ADHD is a risk factor for early initiation of cigarette smoking in the high-risk siblings of ADHD probands
    • Further Evidence of Association Between Behavioral Inhibition and Social Anxiety in Children

      Biederman, Joseph; Hirshfeld-Becker, Dina R.; Rosenbaum, Jerrold F.; Hérot, Christine; Friedman, Deborah; Snidman, Nancy; Kagan, Jerome; Faraone, Stephen V. (American Psychiatric Association Publishing, 2001-10)
      Objective: The authors sought to examine psychopathological correlates of behavioral inhibition in young offspring of parents with panic disorder and/or major depression. Method: Behavioral inhibition, determined by using standard laboratory observations, was assessed in four groups of children (age 2–6 years): 129 children of parents with both panic disorder and major depression, 22 children of parents with panic disorder alone, 49 children of parents with major depression alone, and 84 comparison children of parents with neither panic disorder nor major depression. Psychopathology in children ≥5 years was compared between children with behavioral inhibition (N=64) and without (N=152). Results: Social anxiety disorder (social phobia or avoidant disorder) was significantly more likely to be found in the children with behavioral inhibition (17%) than in those without (5%). Noninhibited children were significantly more likely than inhibited children to have disruptive behavior disorders (20% versus 6%, respectively) and had higher scores on the attention problems scale of the Child Behavior Checklist (mean=52.1 versus 50.8). Conclusions: This study adds to the growing literature suggesting an association between behavioral inhibition and social anxiety disorder and an inverse relationship between inhibition and disruptive behavior disorders.
    • Further investigation of a chromosome 15 locus in schizophrenia: Analysis of affected sibpairs from the NIMH genetics initiative

      Leonard, Sherry; Gault, Judith; Moore, Theodore; Hopkins, Jan; Robinson, Misi; Olincy, Ann; Adler, Lawrence E.; Cloninger, C. Robert; Kaufmann, Charles A.; Tsuang, Ming T.; et al. (Wiley, 1998-07-10)
      Linkage of a neurophysiological deficit associated with schizophrenia, i.e., the failure to inhibit the auditory P50 response, was previously reported at chromosome 15q14. The marker with the highest pairwise lod score, D15S1360, was isolated from a yeast artificial chromosome containing a candidate gene, the α7-nicotinic acetylcholine receptor gene. In the present study, this linkage was further investigated in a subset of the NIMH Genetics Initiative schizophrenia families. These families have not been studied neurophysiologically, as were the families in the original report. Therefore, the DSMIII-R diagnosis of schizophrenia was used as the affected phenotype. Twenty families fulfilled the criteria of at least one sibpair concordant for schizophrenia, along with their two parents or another affected relative outside the nuclear family, available for genotyping. Sibpair analysis showed a significant proportion of D15S1360 alleles shared identical-by-descent (0.58; P < 0.0024). The results further support the involvement of this chromosomal locus in the genetic transmission of schizophrenia. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 81:308–312, 1998. © 1998 Wiley-Liss, Inc.
    • The Future Impact of Immersive Virtual Reality Simulations on the Suburban Training Experience of Firefighters in Westchester, NY

      Tatton III, Edward J (2014-12-01)
      This paper describes a prototype of a firefighter training platform utilizing an immersive virtual reality environment. Advances in technology, with the adoption of virtual reality (VR) systems for training purposes, may provide learners with educational environments with life-like simulation interfaces. A prototype was created to simulate interactions a firefighter might experience in a fully immersive environment. The prototype was used to educate firefighters on the cocncept and survey them for feedback on the proposed learning environment. To achieve a fully immersive virtual reality, visual, tactile, auditory, olfactory and gustatory feedback was used. It was found that a fully immersive virtual reality environment would meet the needs of a successful multimedia design as regards cognition and motivation.
    • Game Streaming in the Wake of a Pandemic: Topic: Live Streaming and Branding

      Jofre, Ana; Martucci, Nicholas; Jofre, Ana; First Reader; Lizardi, Ryan; Second Reader (SUNY Polytechnic Institute, 2020-12)
      The purpose of this study is to determine what the key motivational factors for creating a live stream gaming channel in the wake of a global pandemic are. This is executed by generating a series of podcast interviews from live streamers, generating branding for the launch of a live stream gaming channel and launching the channel. With the world in a current state of emergency, the live streaming industry under Twitch.tv has boomed, giving streamers and viewers alike an opportunity to interact, communicate, and form communities like never before in the shadow of these pressing times. In light of this, we seek an escape from the harsh reality that is quarantine and find comfort in engaging with others all the while having fun indoors.
    • GAMES THAT CAN SAVE LIVES Designing the next generation NYCAMH safety game

      VanDusen, Michael (2012-06-01)
      Abstract not present in the Thesis
    • Gamification & 21st Century Digital Learning

      Galimore, Zipporah; Yucel, Ibrahim; Thesis Advisor; Stam, Kathryn; Second Reader (2018-05)
      Gamification application to instructional methodologies could enhance learning when appropriately implemented. Current research suggests several instructional design principles support principles of gamification. Experts in both gamification and instructional design emphasize certain learning theories and instructional strategies that need to be taken into consideration when integrating gamification in the learning process. Examples provided where effective gamification implemented closely aligns with what current research shows regarding successful multimedia learning and instruction. A virtual learning museum with a butterfly exhibit prototype with examples provided in this paper has been created to give an idea of how gamification and learning design principles should be used simultaneously to enhance cognitive development. Sections of the exhibit are labeled with both gamification and instructional design principals.
    • Gamification of Mobile Fitness Applications for Newly Diagnosed Multiple Sclerosis Patients

      Coupe, Brian (2016-01)
      We can think of our life with mobile technology as a constant classroom and learning environment. Mobile Fitness is a prototype application which will be used by newly diagnosed Multiple Sclerosis patients. The application uses the theory of fun and engagement to keep the user interested and motivated to complete daily workouts. Mobile Fitness uses these game based learning characteristics and human centered design to better suit the user. Recreational therapy also integrates well with gamification because both can be considered with the same end goals in mind. Successful completion of tasks with a reward.
    • Gap Junctional Coupling between Retinal Amacrine and Ganglion Cells Underlies Coherent Spike Activity Integral to Global Object Perception

      Roy, Kaushambi (2017-08)
      Coherent spike activity between neighboring cells is a ubiquitous phenomenon exhibited by ensembles of neurons throughout the central nervous system, including the retina. In addition to the robust coherent activity between neighboring retinal ganglion cells (RGCs), there is evidence that widely separated RGCs can also show correlated spiking. These long range correlations can be evoked by large, contiguous light stimuli, but not to smaller, discontinuous objects. It has thus been posited that long range spike correlations between distant RGCs encode information critical to global object perception. Since the wide separation of the RGCs precludes common excitatory drive from bipolar cells, the mechanism underlying long range concerted activity has remained elusive. Most RGCs show gap junctional coupling to polyaxonal amacrine cells (PACs), which maintain extensive axonal arbors that can extend >1mm across the retina. The electrical coupling between RGCs and PACs thereby form a plausible circuit that can underlie long range correlated activity in the retina. In the current study we tested this hypothesis by targeting and recording from pairs of widely separated ON α-RGCs in the mouse retina, which are coupled indirectly through intermediary PACs. Pharmacological blockade of gap junctions or genetic ablation of connexin36 (Cx36) subunits eliminated the long range correlated spiking between the α-RGCs. These data indicated that electrical coupling between RGCs and PACs was responsible for the long range spike activity. In contrast, I found that direct, serial RGC-RGC coupling was incapable of supporting long range spike correlations. Finally, behavioral experiments were performed to test whether blockade of retinal gap junctions or ablation of Cx36 attenuates the ability of mice to discriminate large, global objects from small, disjointed stimuli. I found that Cx36 knockout mice indeed have significantly reduced ability to discriminate global objects from smaller discontinuous stimuli as compared to wild type littermates. This reduced perception of global objects was not due to a general reduction in spatial acuity that measured in knockout animals was similar to that for wild type mice. Taken together, our results indicate that long range concerted firing between RGCs, derived from electrical coupling with amacrine cells, encodes information critical to global object perception.
    • Generating Facial Character: A Systematic Method Accumulating Expressive Histories

      Jofre, Ana (MIT Press, 2022-04)
      The author presents a method to simulate facial character development by accumulating an expressive history onto a face. The model analytically combines facial features from Paul Ekman’s seven universal facial expressions using a simple Markov chain algorithm. The output is a series of 3D digital faces created in Blender with Python. The results show that systematically imprinting features from emotional expressions onto a neutral face transforms it into one with distinct character. This method could be applied to creative works that depend on character creation, ranging from figurative sculpture to game design, and allows the creator to incorporate chance into the creative process. The author demonstrates the method’s application to sculpture with ceramic casts of generated faces.
    • ?Generic Datasets, Beamforming Vectors Prediction of 5G Celleular Networks

      Kholidy, Hisham A.; Singh, Manjit; Kholidy, Hisham A.; Advisor (SUNY Polytechnic Institute, 2020)
      The early stages of 5G evolution revolves around delivering higher data speeds, latency improvements and the functional redesign of mobile networks to enable greater agility, efficiency and openness. The millimeter-wave (mmWave) massive multiple-input-multiple-output (massive MIMO) system is one of the dominant technology that consistently features in the list of the 5G enablers and opens up new frontiers of services and applications for next-generation 5G cellular networks. The mmWave massive MIMO technology shows potentials to significantly raise user throughput, enhances spectral and energy efficiencies and increases the capacity of mobile networks using the joint capabilities of the huge available bandwidth in the mmWave frequency bands and high multiplexing gains achievable with massive antenna arrays. In this report, we present the preliminary outcomes of research on mmWave massive MIMO (as research on this subject is still in the exploratory phase) and study two papers related to the Millimeter Wave (mmwave) and massive MIMO for next-gen 5G wireless systems. We focus on how a generic dataset uses accurate real-world measurements using ray tracing data and how machine learning/Deep learning can find correlations for better beam prediction vectors through this ray tracing data. We also study a generated deep learning model to be trained using TensorFlow and Google Collaboratory.

      Papillion, Amber (2017)
      IgM memory cells are recognized as an important component of B cell memory, based on several studies both in mice and humans. Our studies of B cells elicited in response to ehrlichial infection identified a population of CD11c/T-bet-positive IgM memory cells and an IgM T-bet-positive bone marrow antibody-secreting cell population (ASCs). The origin of these populations was unknown, although an early T-independent spleen CD11c-and T-bet-positive IgM plasmablast population precedes both, suggesting a linear relationship. The majority of IgM memory cells detected after day 30 post-infection had undergone somatic hypermutation, indicating that they expressed activation-induced cytidine deaminase (AID). Therefore, to identify early AID-expressing precursor cells, we infected an AID-regulated tamoxifen-inducible Cre-recombinase-EYFP reporter strain. Tamoxifen administration led to labeling of both the IgM memory cells and bone marrow ASCs on day 30 and later post-infection. High frequencies of labeled cells were identified on day 30 post-infection,following tamoxifen administration on day 10 post-infection. Both IgM memory cells and IgM bone marrow ASCs were labeled when tamoxifen was administered as early as day 4 post-infection. We also identified mechanisms involved in maintenance of the IgM bone marrow ASCs and IgM+ memory cells, namely proliferation and FcγRIIb respectively. BrdU studies revealed that the bone marrow IgM ASCs were maintained by proliferation, unlike the IgM memory cells. RNAseq analysis revealed a 2-fold higher expression of inhibitory Fc receptor, FcγRIIb. Because FcγRIIb inhibits B cell activation, we hypothesized that FcγRIIb negatively regulates IgM+ memory B cells by binding immune complexes present during low-level chronic infection. E. murisinfection of FcγRIIb-deficientmice revealed a 3-fold expansion of the IgM+ memory 30 days post-infection. We further demonstrated that the expansion of the IgM+ memory cells was not due to increased proliferation, but a decrease of apoptosis, due to a lack of Fas expression in FcγRIIb-deficient mice. This result was mimicked in AID-deficient mice, which lack the ability to class switch to IgG and make immune complexes, revealing a role for immune complexes in regulating IgM+ memory. Altogether, these studies demonstrate a novel germinal center-independent pathway for the generation of two distinct long-term IgM-positive B cell populations.
    • A Genetic Algorithm for Locating Acceptable Structure Models of Systems (Reconstructability Analysis)

      Heath, Joshua; Cavallo, Roger; Advisor; Reale, Michael; Reviewer; Sengupta, Saumendra; Reviewer (2018-05)
      The emergence of the field of General Systems Theory (GST) can be best attributed to the belief that all systems, irrespective of context, share simple, organizational principles capable of being mathematically modeled with any of many forms of abstraction. Structure  modeling is a well‐developed aspect of GST specializing in analyzing the structure of a system ‐ that is, the interactions between the attributes of a system. These interactions, while intuitive in smaller systems, become increasingly difficult to comprehend as the number of measurable attributes of a system increases. To combat this, one may approach an overall system by analyzing its various subsystems and, potentially, reconstruct properties of that system using  knowledge gained from considering a collection of these subsystems (a structure model). In situations where the overall system cannot be fully reconstructed based on a given structure model, the benefits and detriments associated with using such a model should both be considered. For example, while a model may be simpler to understand, or require less storage space in memory than the system as a whole, all information regarding that system may not be inferable from that model. As systems grow in size, determining the acceptability of every meaningful structure model of a system in order tofind the most acceptable becomes exceedingly resource-intensive. In this thesis, a measure of the memory requirements associated with storing a system or a set of subsystems (a structure model) is defined and is used in defining an objective measure of the acceptability of a structure as a representation of an overall system. A Genetic Algorithm for Locating Acceptable Structures (GALAS) is then outlined, with this acceptability criterion serving as an optimizable fitness function. The goal of this heuristic is to search the set of all meaningful structure models, without the need for exhaustively generating each, and produce those that are the most acceptable, based on predefined acceptability criteria. 
    • Genome-wide association study of response to methylphenidate in 187 children with attention-deficit/hyperactivity disorder

      Mick, Eric; Neale, Benjamin; Middleton, Frank A.; McGough, James J.; Faraone, Stephen V. (Wiley, 2008-12-05)
      We conducted a genome-wide association study of symptom response in an open-label study of a methylphenidate transdermal system (MTS). All DNA extraction and genotyping was conducted at SUNY Upstate Medical University using the Affymetrix Genome-Wide Human SNP Array 6.0. All quality control and association analyses were conducted using the software package PLINK. After data cleaning and quality control, there were 187 subjects (72% (N¼135) male) with mean age 9.2 2.0 years and 319,722 SNPs available for analysis. The most statistically significant association (rs9627183 andrs11134178;P¼3 10 6) fell short of the threshold for a genome-wide significant association. The most intriguing association amongsuggestivefindings(rs3792452;P¼2.6 10 5) was with the metabotropic glutamate receptor 7 gene (GRM7) as it is expressed in brain structures also previously associated with ADHD. Among the 102 available SNPs covering previously studied candidate genes, two SNPs within the norepinephrine transporter gene (NET, SLC6A2) were significant at P 1 10 2. These results should be considered preliminary until replicated in larger adequately powered, controlled samples but do suggest that noradrenergic and possibly glutaminergic genes may be involved with response to methylphenidate.
    • Genome-wide search for schizophrenia susceptibility loci: The NIMH genetics initiative and millennium consortium

      Cloninger, C. Robert; Kaufmann, Charles A.; Faraone, Stephen V.; Malaspina, Dolores; Svrakic, Dragan M.; Harkavy-Friedman, Jill; Suarez, Brian K.; Matise, Tara C.; Shore, David; Lee, Hang; et al. (Wiley, 1998-07-10)
      chizophrenia has a complex pattern of inheritance, indicative of interactions among multiple genes and environmental factors. The detection and replication of specific susceptibility loci for such complex disorders are facilitated by the availability of large samples of affected sib pairs and their nuclear families, along with standardized assessment and systematic ascertainment procedures. The NIMH Genetics Initiative on Schizophrenia, a multisite collaborative study, was established as a national resource with a centralized clinical data base and cell repository. The Millennium Schizophrenia Consortium has completed a genome-wide scan to detect susceptibility loci for schizophrenia in 244 individuals from the nuclear families of 92 independent pairs of schizophrenic sibs ascertained by the NIMH Genetics Initiative. The 459 marker loci used in the scan were spaced at 10-cM intervals on average. Individuals of African descent were higher than those of European descent in their average heterozygosity (79% vs. 76%, P < .0001) and number of alleles per marker (9.2 vs. 8.4, P < .0001). Also, the allele frequencies of 73% of the marker loci differed significantly (P < .01) between individuals of European and African ancestry. However, regardless of ethnic background, this sample was largely comprised of schizophrenics with more than a decade of psychosis associated with pervasive social and occupational impairment. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 81:275–281, 1998. © 1998 Wiley-Liss, Inc.

      Glatt, Stephen; Tylee, Daniel (2017)
      Autism is a complex neurodevelopmental syndrome that can be challenging to identify in young children. Family-based and genetic studies indicate that autism has a strong genetic component, though immunologic processes may also contribute to altered neurodevelopment. Over the past two decades, genome-wide investigations have provided critical insights into the genetic causes and molecular correlates of autism at the levels of both the individual and the population. Studies of DNA have identified highly penetrant genetic factors that appear to explain a sizable minority (20-40%) of autism-affected individuals. However, patho-developmental mechanisms are less-clearly understood for the remaining majority of individuals for whom no highly penetrant factors are identifiable(i.e., idiopathic autism). The present body of work contains three studies that used genome-wide assessment methods to predict the diagnosis of autism and to characterize its molecular correlates using samples that predominantly reflect idiopathic etiology. In Chapter 1, we demonstrate that large numbers of low-penetrance genetic factors(i.e., commonly varying single nucleotide polymorphisms; SNPs) can be harnessed with machine-learning methods to predict autism risk. Throughout this document, we provide a review and critical evaluation of DNA-and RNA-based autism biomarkers. In Chapters 2 and 3, we use microarray and RNA sequencing to identify consistent patterns of autism-related gene expression in peripheral blood samples. These patterns shed light on altered immunologic signaling and also implicate signaling pathways that are known to be involved in neurodevelopment and to influence autism-related clinical and neurobiological phenotypes. Importantly, our findings indicate that the molecular correlates of idiopathic autism may converge with mechanisms understood from high-penetrance genetic causes. Furthermore, our findings support the idea that immunologic mechanisms could contribute to perturbations of neurodevelopmental pathways. We integrate our findings in the context of existing literature, highlight current gaps in knowledge, and propose future experiments to address these questions.
    • The Global Module Project: Developing and Troubleshooting Online Discussion Session between Empire State College Students Based in Panama and SUNYIT Students from New York State

      Rodick, Alena (2013-05-01)
      The purpose of this project was to set up an online cross-cultural collaboration module between students located around New York State and another group in Panama City, Panama. Using cognitive psychology approaches to learning, the author of the thesis designed an effective online space and module structure for two groups of students to introduce each other, participate in the discussions, and provide critical reflection about participation in the module. AWordPress site was created wherein students provided responses to a set of videos. The students all met at an Elluminate session and later reflected on the experience in an Angel discussion group. The author of the thesis journaled how she designed the online learning space and documented the effects of the use of the online group discussions and online meeting space on the group interaction. She also had students in both groups evaluate the tools used in the experiment.
    • Google Glass In the Classroom

      Nicosia, Sylvia Navarro (2015-05-01)
      This project is a prototype application for Google Glass that would help horticultural students with the difficult task of plant identification. The main purpose is to determine if a wearable device, embedded with augmented reality, can enhance both teaching and learning, using Cognitive Theory principles, by improving engagement and motivation. The prototype was built using JustInMind, a prototyping application, which allows prototypes to run in Google Glass. Three students and two faculty members from the Horticultural Department tested the application; all concurred that this application had potential, as long as the underlying database was comprehensive.
    • A Guide to Mobile Apps for Small Cultural Heritage Non-Profits: Leveraging Mobile Technologies to Guide and Engage Visitors

      Parker, Danielle; Schneider, Steven; Advisor; Kahn, Russell; Second Reader (2017-12)
      Constrained by limited staffing and tight budgets, small, cultural heritage non-profits may struggle to promote visitation and engage visitors who do make on-site visits. This paper identifies the opportunities mobile technologies can provide to bridge the gap between cultural heritage organizations and their visitors. Current research on the use of digital media and mobile technology in the museum field, as well as research on museum visitor motivations and learning, are explored. Based on study findings and expert recommendations, key design factors for a mobile app to be used at all stages of a visit are determined. The design themes of wayfinding, personalization, multimedia, and relationship-building are explored. Small historic non-profits can benefit by leveraging these mobile design features to enrich the visitor experience. This thesis project consists of the design and development of Web-based guide (Web site) including a case study and an example Request for Proposal (RFP) to educate historic non-profit administrators on the opportunities for implementing these features at their organizations.

      Stam, Kathryn; Thesis Advisor; Lizardi, Ryan; Second Reader; Niles, JoAnna (2021-05)
      Throughout the years, Natural Hair has been used as a form of expression, self-acceptance, and controversy in the United States of America. The invention of Web 2.0, the rise of social media, blogs, and other web-based platforms has given members of the Natural Hair community a platform to share their personal stories and tips related to natural hair care with others. This project looked at the effects of Web 2.0 during the second wave of the Natural Hair Movement since the year 2008, showcasing various hairstyles through digital photography and personal narratives of five individuals. Previous studies have shown that men and women with naturally curly hair have faced some form of discrimination based on their hairstyle, causing them to assimilate to societal norms of wearing their hair straight. The goal for this project was to showcase the versatility of natural hair through digital photography and personal narratives as a form of storytelling, and sharing how social media and other outlets across the web have impacted the individual’s decision to wear their hair in its natural state or how it has helped them in their natural hair journey. Photos of five different people of various cultural backgrounds, hair textures, and lifestyles were taken and questions based on their Natural Hair journey were asked. With the collection of photographs and narratives, a Capstone portfolio section of my media website was created for public viewing. This platform can be updated as photos of more individuals with natural hair at local events and expos in the future are taken.