• HAIR LOVE: SHOWCASING THE DIVERSITY OF NATURAL HAIR THROUGH PHOTOGRAPHY AND PERSONAL NARRATIVES

      Stam, Kathryn; Thesis Advisor; Lizardi, Ryan; Second Reader; Niles, JoAnna (2021-05)
      Throughout the years, Natural Hair has been used as a form of expression, self-acceptance, and controversy in the United States of America. The invention of Web 2.0, the rise of social media, blogs, and other web-based platforms has given members of the Natural Hair community a platform to share their personal stories and tips related to natural hair care with others. This project looked at the effects of Web 2.0 during the second wave of the Natural Hair Movement since the year 2008, showcasing various hairstyles through digital photography and personal narratives of five individuals. Previous studies have shown that men and women with naturally curly hair have faced some form of discrimination based on their hairstyle, causing them to assimilate to societal norms of wearing their hair straight. The goal for this project was to showcase the versatility of natural hair through digital photography and personal narratives as a form of storytelling, and sharing how social media and other outlets across the web have impacted the individual’s decision to wear their hair in its natural state or how it has helped them in their natural hair journey. Photos of five different people of various cultural backgrounds, hair textures, and lifestyles were taken and questions based on their Natural Hair journey were asked. With the collection of photographs and narratives, a Capstone portfolio section of my media website was created for public viewing. This platform can be updated as photos of more individuals with natural hair at local events and expos in the future are taken.
    • Heterogeneity and the genetics of bipolar disorder

      Faraone, Stephen V.; Tsuang, Ming T. (Wiley, 2003-10-30)
    • High Performance Distributed Big File Cloud Storage

      Shakelli, Anusha; Sengupta, Sam; Adviser; White, Joshua; Reviewer (2016-05-01)
      Cloud storage services are growing at a fast rate and are emerging in data storage field. These services are used by people for backing up data, sharing file through social networks like Facebook [3], Zing Me [2]. Users will be able to upload data from computer, mobile or tablet and also download and share them to others. Thus, system load in cloud storage becomes huge. Nowadays, Cloud storage service has become a crucial requirement for many enterprises due to its features like cost saving, performance, security, flexibility. To design an efficient storage engine for cloud based systems, it is always required to deal with requirements like big file processing, lightweight metadata, deduplication, high scalability. Here we suggest a Big file cloud architecture to handle all problems in big file cloud system. Basically, here we propose to build a scalable distributed data cloud storage that supports big file with size up to several terabytes. In cloud storage, system load is usually heavy. Data deduplication to reduce wastage of storage space caused by storing same static data from different users. In order to solve the above problems, a common method used in Cloud storages, is by dividing big file into small blocks, storing them on disks and then dealing them using a metadata system [1], [6], [19], [20]. Current cloud storage services have a complex metadata system. Thereby, the space complexity of the metadata System is O(n) and it is not scalable for big file. In this research, a new big file cloud storage architecture and a better solution to reduce the space complexity of metadata is suggested.
    • How Can a University Approach the Construction of a Blog Space For Use as a Recruiting Tool?

      Washburn, Teresa M.R. (2006-08-01)
      This case study examines the social construction of a blog space to recruit prospective students. The blog space initially created by SUNYIT is examined and compared with other existing blog spaces at accredited universities in New York State. The research in this case study is based on web site observations, interviews, questionnaires, review of literature and an information session. The theory of sensemaking and organizational culture (participatory culture, specifically) are applied to help understand the case and context.
    • How Colleges Have Responded to Changes In Student Recruitment as Defined By Their Level of Web Definition on Their Official College Web Sites

      Ayouch, Karen (2007-08-01)
      Increased competition amongst colleges, advances in technology and the changing wants and needs of the target market has influenced colleges to expand their marketing techniques globally through the use of the World Wide Web. One hundred randomly selected college websites were analyzed for specific criteria found on the main page or any page that can be accessed from the main page. Demographic information was also collected about the colleges to look for potential trends in the level of web definition. The level was web definition was defined by specified criteria in the areas of technology implementation, interactivity and marketing concepts. The findings show that the area of marketing had the greatest number of colleges assigned to the medium-high level of web definition for both potential and actual number of points assigned and the area interactivity had the greatest number of colleges assigned to the low-medium level of web definition.
    • How Decisions Are Made When Creating Information Design Exhibits for Museums

      Yahnke, David R. (2008-12-01)
      This case study illustrates how and when decisions are made during the creative process occurring within two cultures: Graphic Designers and Museum Exhibitors. This study investigates the pre-visual creative process and fabrication of exhibits concerning the history of farming in Oneida County and the history of New York State during the American Revolutionary War at the Marcus Willet Visitors Center at Fort Stanwix in Rome, NY. This study will apply wayfinding theories to information design practice; the result is a field guide for both graphic and museum designers. This case study explains the nature of decision-making used in creation of information design. The particular project to be studied is the design of a permanent exhibit for a community historical society. Each decision to be made is documented; details are provided regarding what decisions are made, who makes the decisions, when decisions are made, and the many factors that impact the decision-making process. The case study is a description of this particular design process and a guide to the way in which decisions are made in information design. The major decisions concern the audience, content, means of wayfinding, design consistency, color, typographic parameters, size, and viewing distances. This study explores the impact these decisions had on the final exhibition design.
    • How is GIS used in a Community College Setting for Architectural Identification

      Judycki, Brian (2005-05-01)
      This case study analyzes how students use an Architectural Identification GIS Application in a community college setting.
    • The Hybrid Course Experience

      Thompson, Jonathan M (2005-05-01)
      This phenomenology analyzes the experience of students and teachers in hybrid (blended) courses in a community college and a university located in central New York.The Constructivist Learning Theory is applied to the hybrid course characteristics and analyzed to determine the effectiveness of hybrid courses. A definition and description of hybrid courses is proposed.
    • Hypertextual Teaching in a TiddlySpace Educational Environment

      Shaw, Jason (2013-05-01)
      This thesis project uses first-hand observation and academic inquiry to inform the design and implementation of a hypertext-capable alternative online learning system in an open source wiki, called TiddlySpace. This system is then used as the educational environment in which students, with minimal hypertextual experience, are taught to think hypertextually and record their work in a collaborative hypertext environment. The researcher finds TiddlySpace to be dynamic enough to handle mid-semester changes and also powerful enough to support a wide range of academic assignments. The bulk of these assignments required students to create a large amount of structured microcontent, which appeared to encourage hypertext literacy. Finally, the researcher examines the idea that increased hypertextual literacy may encourage conceptual learning in a greater sense.
    • IDENTIFICATION OF p53-MEDIATED NEUROGENOMIC RESPONSES TO ETHANOL USING IN VIVO AND IN VITRO MODELS OF FETAL ALCOHOL SPECTRUM DISORDER

      Camargo, Maria (2016)
      Fetal Alcohol Spectrum Disorder (FASD) is a serious public health concern affecting 3.6% of the US population. One avenue to achieve a decrease in the prevalence of FASD is for scientific research to identify cellular mechanisms of action of imbibed alcohol and propose solutions to treat or prevent the damage done. Here we present our investigation into the molecular consequences of ethanol exposure in mouse brain cells and mouse neural stem cell cultures. Specifically, we tested the hypothesis that p53 mediates the neurogenomic response to ethanol exposure in brain cells in the somatosensory cortex, hippocampus and neural stem cells. p53 is a versatile transcription factor well known for inducing cell death in cancer cells. We identified the apoptosis pathway as being changed in a p53-related manner only in the CA1 subregion of the hippocampus, based on expression changes in Casp2, Cdk1, and Stat1. Overall, the regions interrogated revealed that p53’s cellular response is heterogeneous. In the somatosensory cortex and hippocampus a subset of gene expression changes occurred depending on both ethanol exposure and the presence of p53: Ephb1in layer 2/3; Ctgf in layer 5; Camk1 in layer 6; Cdk1, Casp2, Cdk1, and Stat1 in the CA1; and Camk1 in the DG. In regards to the specific mRNAs that changed, they differed in the brain regions and cell cultures, but we did observe that neuronal and developmental genes were the most significantly changed upon ethanol exposure. In addition, we also identified that the category of genes whose methylation pattern was changed after ethanol exposure are related to basic neuronal functions. Neural cells also appeared to be engaged in a challenging response to ethanol because DNA repair proteins Ercc1, Hus1, and Rad51 alter their DNA binding after ethanol exposure. In addition, we identified that p53 transcription factor changes its DNA binding in response to ethanol exposure. In conclusion, we identified that neural p53 signaling is measurably perturbed by ethanol exposure.
    • Identification of TIMP2 as the first secretory co-chaperone of eHSP90

      Dimitra Bourboulia; Baker-Williams, Alexander J. (2021)
      Heat Shock Protein- 90 (HSP90) is an essential molecular chaperone. HSP90 relies on its intrinsic ATPase activity as well as interactions with co-chaperone proteins to chaperone its clients. HSP90 is also an extracellular protein, performing both a signaling and chaperoning role. Extracellular client, matrix metalloproteinase-2 (MMP2) relies on HSP90 for its stability. MMP2 mediates extracellular matrix remodeling through its gelatinolytic activity. MMP2 activity is also tightly regulated by its endogenous inhibitor, the Tissue Inhibitor of Metalloproteinase-2 (TIMP2). At present how HSP90 performs its chaperoning role in the extracellular matrix is uncertain. In this thesis, I describe that TIMP2 acts as the first bona fide extracellular co-chaperone of eHSP90, and show that TIMP2 is a stress inducible protein. I describe how TIMP2 directly interacts with HSP90, and how TIMP2 decelerates the HSP90 ATPase cycle. TIMP2 also sensitizes HSP90 to both ATP and N-terminal pharmaceuticals. Overall, TIMP2 acts as both a scaffold and a disruptor of the client/chaperone relationship between MMP2 and HSP90, performing both a HSP90 co-chaperone and MMP2 inhibitor role, non-mutually exclusively. The activatory co-chaperone AHA1 competes with TIMP2 for HSP90 binding. TIMP2 and AHA1 are able to form two independent ternary complexes with MMP2 and HSP90; as a result, the TIMP2 complex is MMP2 proteolytically inactive and the AHA1, active. This competition is further described in vivo where it can be inhibited by both _AHA1 antibodies and TIMP2 AHA1 antibodies and TIMP2 exogenous protein treatments, whilst induced following AHA1 protein and _AHA1 antibodies and TIMP2 TIMP2 antibody treatments. Finally, the role of phos-Y-TIMP2 was examined in relation to its interaction with HSP90. To address this, a novel methodology to purify hTIMP2 from E.Coli without previously necessary refolding strategies in a scale-able manner suitable for therapeutic TIMP2 treatments, was developed. Wild type recombinant human TIMP2 and phospho-mutants Y90E, Y90F, and TE (Y62E, Y90E, Y165E) were purified, were inhibitory towards MMP2, and modulated TIMP2 interaction with HSP90. Taken together, I demonstrate how extracellular HSP90 is regulated by co-chaperones to facilitate the chaperoning of pro-invasive client, MMP2. It further shows ways in which we can manipulate this system to promote an inactive MMP2 protease, a key strategy in cancer therapeutics.
    • Image Processing In F#

      Odoi, Kaia; Andriamanalimanana, Bruno; Advisor; Novillo, Jorge; Reviewer; Sengupta, Sam; Reviewer (2017-05-01)
      Image searching is an essential feature of many software applications. Histograms can be used to represent the pixel color intensities of images. Measuring the similarities between images by comparing the histograms can be performed through the use of information-theoretic measures, such as the Kullback-Leibler divergence and cross-entropy. In this project, a query image is selected from a collection of images and it is compared to the other images to determine which image is most similar to the query image. This process is carried out by creating histograms of each image, and then using measures such as the Kullback-Leibler divergence and cross-entropy to compare the histograms. The .NET functional language, F#, is used in the implementation of this project. The C# language, another .NET language, was also used for coding the graphical user interface.
    • Impact of Psychometrically Defined Deficits of Executive Functioning in Adults With Attention Deficit Hyperactivity Disorder

      Biederman, Joseph; Petty, Carter; Fried, Ronna; Fontanella, Jessie; Doyle, Alysa E.; Seidman, Larry J.; Faraone, Stephen V. (American Psychiatric Association Publishing, 2006-10)
      Objective: The association between deficits in executive functioning and functional outcomes was examined among adults with attention deficit hyperactivity disorder (ADHD). Method: Subjects were adults who did (N=213) and did not (N=145) meet DSMIV criteria for ADHD. The authors defined having deficits in executive functioning as having at least two measures of executive functioning with scores 1.5 standard deviations below those of matched comparison subjects. Results: Significantly more adults with ADHD had deficits of executive functioning than comparison subjects. Deficits of executive functioning were associated with lower academic achievement, irrespective of ADHD status. Subjects with ADHD with deficits of executive functioning had a significantly lower socioeconomic status and a significant functional morbidity beyond the diagnosis of ADHD alone. Conclusions: Psychometrically defined deficits of executive functioning may help identify a subgroup of adults with ADHD at high risk for occupational and academic underachievement. More efforts are needed to identify cost-effective approaches to screen individuals with ADHD for deficits of executive functioning.
    • The Impact of Staff Development on Middle School Technology Integration

      Scalisi, Regina (2005-05-01)
      This case study describes the impact of technology staff development in two Central New York Middle Schools. The staff development program was implemented under the federally funded Enhancing Education Through Technology grant. Teachers and students were studied during a seven-month period as they learned to effectively use computers, Internet resources and available software with their curricula and instruction. The conditions of Change Theory were applied to the study as they relate to the adoption of technology integration.
    • Impact of Tic Disorders on ADHD Outcome Across the Life Cycle: Findings From a Large Group of Adults With and Without ADHD

      Spencer, Thomas J.; Biederman, Joseph; Faraone, Stephen V.; Mick, Eric; Coffey, Barbara; Geller, Daniel; Kagan, Jake; Bearman, Sarah Kate; Wilens, Timothy (American Psychiatric Association Publishing, 2001-04)
      Objective: The impact of tic disorders on the outcome of attention deficit hyperactivity disorder (ADHD) remains a subject of high scientific and clinical interest. To evaluate the impact of comorbid ADHD and tic disorders from a lifespan perspective, the authors systematically examined data from adults with and without ADHD. Method: They comprehensively evaluated 312 consecutively referred adults with ADHD and 252 comparison subjects without ADHD. Tic disorders were characterized along with a wide range of neuropsychiatric correlates, including other comorbid disorders as well as indexes of function in the domains of school, cognition, and interpersonal functioning. Results: A significantly greater proportion of adults with ADHD (12%) than those without ADHD (4%) had tic disorders. Tic disorders followed a mostly remitting course and had little impact on functional capacities. In addition, tic disorders were not associated with stimulant use. Conclusions: These findings in adults with ADHD confirm and extend previous findings in young subjects with ADHD, documenting that although individuals with ADHD are at greater risk for tic disorders, the presence of tic disorders has a limited impact on ADHD outcome.
    • The Influence of College Web Sites on the College Selection Process

      Basi Raab, Maryrose (2005-12-01)
      This case study examines the use and influence of college web sites by high school seniors as they move through the college selection process through interviews, directed observations, and focus groups. It discovers and describes the different ways that web sites are used by this bounded group. As a part of the study, the re-designed web site at SUNY Institute of Technology is critiqued and analyzed by respondents. Enhancements are proposed based on the research to increase the effectiveness of the site in its appeal to prospective high school students. The theories of Human-Centered Design and Contextual Design are described and applied to this case study.
    • Influence of Gender on Attention Deficit Hyperactivity Disorder in Children Referred to a Psychiatric Clinic

      Biederman, Joseph; Mick, Eric; Faraone, Stephen V.; Braaten, Ellen; Doyle, Alysa; Spencer, Thomas; Wilens, Timothy E.; Frazier, Elizabeth; Johnson, Mary Ann (American Psychiatric Association Publishing, 2002-01)
      Objective: The substantial discrepancy in the male-to-female ratio between clinic-referred (10 to 1) and community (3 to 1) samples of children with attention deficit hyperactivity disorder (ADHD) suggests that gender differences may be operant in the phenotypic expression of ADHD. In this study the authors systematically examined the impact of gender on the clinical features of ADHD in a group of children referred to a clinic. Method: The study included 140 boys and 140 girls with ADHD and 120 boys and 122 girls without ADHD as comparison subjects. All subjects were systematically assessed with structured diagnostic interviews and neuropsychological batteries for subtypes of ADHD as well as emotional, school, intellectual, interpersonal, and family functioning. Results: Girls with ADHD were more likely than boys to have the predominantly inattentive type of ADHD, less likely to have a learning disability, and less likely to manifest problems in school or in their spare time. In addition, girls with ADHD were at less risk for comorbid major depression, conduct disorder, and oppositional defiant disorder than boys with ADHD. A statistically significant gender-by-ADHD interaction was identified for comorbid substance use disorders as well. Conclusions: The lower likelihood for girls to manifest psychiatric, cognitive, and functional impairment than boys could result in gender-based referral bias unfavorable to girls with ADHD
    • The influence of genes on “positive valence systems” constructs: A systematic review

      Hess, Jonathan L.; Kawaguchi, Daniel M.; Wagner, Kayla E.; Faraone, Stephen V.; Glatt, Stephen J. (Wiley, 2015-09-14)
      The Research Domain Criteria (RDoC) address three types of aggression: frustrative non-reward, defensive aggression and offensive/proactive aggression. This review sought to present the evidence for genetic underpinnings of aggression and to determine to what degree prior studies have examined phenotypes that fit into the RDoC framework. Although the constructs of defensive and offensive aggression have been widely used in the animal genetics literature, the human literature is mostly agnostic with regard to all the RDoC constructs. We know from twin studies that about half the variance in behavior may be explained by genetic risk factors. This is true for both dimensional, trait-like, measures of aggression and categorical definitions of psychopathology. The non-shared environment seems to have a moderate influence with the effects of shared environment being unclear. Human molecular genetic studies of aggression are in an early stage. The most promising candidates are in the dopaminergic and serotonergic systems along with hormonal regulators. Genome-wide association studies have not yet achieved genome-wide significance, but current samples are too small to detect variants having the small effects one would expect for a complex disorder. The strongest molecular evidence for a genetic basis for aggression comes from animal models comparing aggressive and non-aggressive strains or documenting the effects of gene knockouts. Although we have learned much from these prior studies, future studies should improve the measurement of aggression by using a systematic method of measurement such as that proposed by the RDoC initiative. © 2015 Wiley Periodicals, Inc.
    • Influence of Parental SUD and ADHD on ADHD in their Offspring: Preliminary Results from a Pilot-controlled Family Study

      Wilens, Timothy E.; Hahesy, Amy L.; Biederman, Joseph; Bredin, Elizabeth; Tanguay, Sarah; Kwon, Anne; Faraone, Stephen V. (Wiley, 2005-03)
      As part of a pilot-controlled family-based study of the children of parents with and without substance use disorders (SUD), the influence of parental SUD and ADHD on the risk for ADHD in offspring was evaluated. Using structured psychiatric interviews, 96 families (183 youth; mean age 11.6 years) were assessed. To evaluate the effect of parental ADHD and SUD, the offspring were stratified into four groups based on parental status: children of parents with neither ADHD nor SUD, children of parents with SUD only, children of parents with ADHD only, and children of parents with both ADHD and SUD. Using generalized estimating equation models, parental SUD and ADHD were used to predict ADHD in the offspring. The rate of children with ADHD increased among children of parents with neither disorder (3%), children of parents with SUD (13%), children of parents with ADHD (25%), and children of parents with both ADHD and SUD (50%) (p ¼ :001). Children of parents with ADHD or ADHD plus SUD were more likely to have ADHD in comparison to children of parents with neither diagnosis (p < 0:05). Children of parents with ADHD plus SUD were at greater risk of ADHD in comparison to children of parents with SUD only (p ¼ 0:01). Despite the small sample size, the results of this study seem to suggest that the offspring of SUD or ADHD parents are at elevated risk for ADHD compared to controls. The offspring of parents with both ADHD and SUD appear to be at the highest risk for ADHD, highlighting the need for careful screening of this group of youth for ADHD. Replication studies clarifying the nature and strength of the association are necessary.