• E-Learning Electricity A Web-Based Training System: Applied to Teaching the Fundamentals and Function of Electrical Theory as it relates to Direct Current Automotive Circuits

      Stam, Kathryn; Advisor; Lizardi, Ryan; Second Reader; Vair, William Scott (2019-08)
      The purpose of this thesis project is to create a proposal for a new e-learning program that would span the gap between the theoretical and real-world application of electrical theory as it relates to automotive direct current circuits. This proposed e-learning program will currently be focused on the subject of automotive direct current circuits, but is considered scalable for other subjects in the future. The application of this proposed e-learning program is to be used by learners as a resource to help deepen their knowledge through active learning and subject mastery. Active learning and subject mastery are be achieved by utilizing simulation and gamification as a means of engaging and motivating the learner. This will be accomplished within this proposed e-learning program by implementing the principles of Piaget’s Theory of Constructivism, Jerome Bruner’s Theory of Discovery Learning and Bloom & Carroll’s Theory of Mastery of Learning (Bates, 2016). This proposal also includes design mockups for the homepage, interactive activities, learning games and an assessment quiz. It is my intention to someday see this proposed e-learning program become a reality and be implemented for the future enhancement of education and the edification of learners.
    • E-Learning: How Constructivist Learning Theory Guides Module Learning

      Cannarelli, Gabriella; Kahn, Russell; Advisor; Schneider, Steven; Reviewer (2016-12-01)
      This paper will review the theory behind constructivism and how it connects to module based e-learning. Social and cognitive constructivism have similar views, but they are very different. Constructivism calls for a student to learn based off of previous experiences and building on that knowledge to make new assumptions. People argue the effectiveness of module learning, but many find it to be the up and coming way of learning. Technology usage is getting greater and greater all the time so why not shift how we do education? e-learning is the way of the future. Learning modules utilizing learning management systems offer a direct route to both successful learning, but also connects to the theory around constructivism.
    • E-Orientation for Clinton Community College

      Aubrey, Jessica (SUNY Polytechnic Institute, 2019-05)
      Clinton Community College has faced continued declining enrollments for the last five years, resulting in the College’s active pursuit of proven student retention mechanisms to assist with enrollment stabilization. The College has decided to create an online orientation module in Moodle to improve the “new student experience” and support a smooth onboarding process that effectively provides students with information critical to their success as well as aids in their ability to better navigate the college experience. In addition, the college seeks to encourage student self-awareness, learning skills and familiarity with the online learning platform. These intentionally designed interactions delivered via an E-orientation model that employs scholarly proven information design, constructivist and social constructivist theories will ensure the College’s new E-Orientation will foster student success and retention.
    • Ecommerce for a Mid-Sized Medical Device Company: A Consultant's Report Approach

      Hamilton, Dan (2017-12)
      The medical device industry generates hundreds of billions of dollars in revenue every year. While the supply chain of some healthcare institutions runs with optimum efficiency through supply chain management (SCM) systems such an Infor Lawson, others are not always managed in such a fashion. These less efficient supply chains tend to be those of smaller facilities and standalone doctor offices that do not participate in the larger Group Purchasing Organizations (GPOs) that offer the supply chain efficiency, discounts, and economies of scale enjoyed by larger institutions (Jayaraman et al., 2014). Many companies, except for the largest players in the field such as Bard, Cook, and Boston Scientific to name a few, are still operating their medical device sales to these smaller practices with phone calls, fax machines, and email. This practice of manual salesmanship can be time consuming, expensive, and labor intensive. But it doesn’t have to be. For this project, I will focus on an actual mid-sized company in the medical device industry (referred to in this report as “Med Dev Company”) that pulls in roughly $400 million in annual revenue. The company is positioned to increase revenue over the coming years, but could use a process that streamlines orders for some of its products, especially those for its smaller customers. Med Dev Company sells a variety of medical devices, from simple disposable syringes and suture retention devices, to implantable catheters, to large surgical machines that require a high level of proficiency to operate. While not all of these products are able to be sold online through an ecommerce portal, many that are considered to be disposable, near the end of their product life-cycle, or tried and true “commodity” items, could certainly be sold via an ecommerce portal with ease. In a healthcare environment where device purchasing costs are often the difference between a clinic staying open or closing its doors for good, efficient and cost-effective management of device procurement is vital (Jayaraman, et al. 2014). My goal for this project is to identify how the current sales process works at the Med Dev Company and the medical device industry in general, identify some key players in the medical device industry who operate in an ecommerce marketplace efficiently, assess the benefit and risks of ecommerce, and propose whether or not Med Dev Company should develop its own ecommerce environment for the appropriate products and customers. I will not be creating an actual ecommerce site for this project, however. The final output will instead take the shape of a consultant’s report to Med Dev Company, as well as an accompanying slide deck.
    • An Educational Website on Copyright Law and Remix Art

      Bugyi, John P (2013-12-01)
      Technological developments have led to various types of information (i.e., art, music, ideas, etc) that can be spread widely throughout the web for people to view, use, and share. The growth of technology and its capabilities has led to the popularity of remix art. Legal debate, however, has also increased as copyright law and the fair use doctrine has not grown at the same rate as technology. In this thesis paper and web design project, I present my research on remix art, copyright law, the fair use doctrine, and the effects of each. In the paper, I provide an overview of each topic. I also discuss how a website can be used as an engaging learning tool, how information architecture can create a responsive and accessible website, how the human-centered design theory promotes learning, and how the effectiveness of a website as a learning tool can be measured. I designed my website to be an online learning tool for undergraduate students so that they may better understand how to use and create legal remix art. The research used in this paper and website have been limited to examples of remix art, basic guidelines for legal remix art, court case examples, and the creative commons. My website is based on a human-centered design approach and other multimedia design methods that parallel the topic of remix art through the use of wikis, polls, and quizzes. A list of references was also included to guide and promote further study on the topic, as this paper and website was designed to give an overview of the topics rather than to provide legal advice. I prepared this thesis paper and website project by considering the content, target population, and design theories individually and as interacting factors.
    • Effectiveness and Tolerability of Tomoxetine in Adults With Attention Deficit Hyperactivity Disorder

      Spencer, Thomas; Biederman, Joseph; Wilens, Timothy; Prince, Jeffry; Hatch, Mary; Jones, Janice; Harding, Margaret; Faraone, Stephen V.; Seidman, Larry (American Psychiatric Association Publishing, 1998-05)
      Objective: The authors assessed the experimental noradrenergic compound tomoxetine as an alternative treatment for adult attention deficit hyperactivity disorder (ADHD). Method: They conducted a double-blind, placebo-controlled, crossover study of tomoxetine in 22 adults with well-characterized ADHD. Results: Treatment with tomoxetine at an average oral dose of 76 mg/day was well tolerated. Drug-specific improvement in ADHD symptoms was highly significant overall and sufficiently robust to be detectable in a parallel-groups comparison restricted to the first 3 weeks of the protocol. Eleven of 21 patients showed improvement after receiving tomoxetine, compared with only two of 21 patients who improved after receiving placebo. Significant tomoxetine-associated improvement was noted on neuropsychological measures of inhibitory capacity from Stroop tests. Conclusions: This preliminary study showed that tomoxetine was effective in treating adult ADHD and was well tolerated. These promising results provide support for further studies of tomoxetine over an extended period of treatment.
    • Effectiveness of Disseminating the Migrant Clinician’s Reference Manual Online

      Hawkes, Lynae (2009-05-01)
      Migrant and seasonal farmwokers are a socially disadvantaged population, working in the Nation’s most dangerous industry. Due to social isolation, cultural and linguistic barriers, coupled with a hazardous work environment, this population is thought to be at increased risk for work-related health problems. The primary sources of healthcare for farmworkers are federally funded migrant health programs located in highly agricultural areas throughout the United States. However, studies show that healthcare providers are ill-equipped to properly diagnosis and treat this patient population. A clinic resource was developed to meet the needs of those serving farmworkers in the Northeast. This case study evaluates the effectiveness of disseminating this resource on the World Wide Web. The migrant health center environment and prior Internet usage were of particular interest. Application of the Sense Making theory suggests critical gaps exist in the health literacy of migrant and seasonal farmworkers, wherein the migrant health reference manual serves as a bridge between provider and patient. Findings further suggest that the manual has a positive impact on patient care by addressing six focus areas of the Health People 2010 Health Literacy Initiative (USDHHS, 2000, p29): 1) Access to Quality Health Services 2) Arthritis, Osteoporosis, and Chronic Back Conditions 3) Environmental Health 4) Health Communication 5) Occupational Safety and Health 6) Public Health Infrastructure
    • The Effects of Facebook Images on Women’s Self-Esteem and Body Image

      PladoCostante, MaryMargaret (2013-05-01)
      This project looked at the effects Facebook images have on women’s self-esteem and body image. Previous studies have shown how women are negatively effected by the images they are presented with in the media by way of magazines and television. Therefore, with this study my goal was to see if the same was held true through social media such as Facebook. For this project I analyzed Elle, Glamour and Vogue’s Facebook pages. In particular I analyzed 40 images of women on each of their Facebook pages. From there I wanted to find if the number of likes the images received were related to how sexualized the women were in each of the images. Through this study I found that highly sexualized images do receive more likes than images that were less sexualized. This conclusion supported by hypothesis. In addition, the following study shows how marketing and advertising has not changed as technology has advanced. Even through social media, women are constantly being exposed to images that can have a negative impact on them in a variety of ways.
    • EFFECTS OF FOCAL SEGMENTAL GLOMERULOSCLEROSIS-ASSOCIATED MUTATIONS ON MYOSIN 1E LOCALIZATION AND ACTIVITY

      Krendel, Mira; Karchin, Jing Bi (2015)
      Our lab has discovered that an actin-dependent molecular motor called Myosin 1e (Myo1e) is required for maintaining normal morphology and function in vivo of podocytes, a specialized epithelial cell in the kidney. We have found that Myo1e-null mice develop proteinuria, and mutations in the MYO1E gene, including missense mutations A159P and T119I, and nonsense mutation Y695X, have been identified in focal segmental glomerulosclerosis (FSGS), a primary kidney disease that often leads to end stage renal disease (ESRD). Based on these findings, we have proposed that Myo1e and especially its motor domain, plays a key role in regulating actin cytoskeleton organization in kidney podocytes. To study Myo1e activity at the junctions, we have used cell culture systems. We confirmed that Myo1e is a component of the podocyte slit diaphragm using glomerular fractionation assay and immune-gold labeling electron microscopy. Disruption of Myo1e motor activity by point mutation (A159P) completely disrupted Myo1e cellular localization and led to defective actin assembly at nascent cell-cell contacts. Domain mapping experiments in MDCK cells have suggested that the Myo1e TH2 domain is necessary, but not sufficient for its localization, but addition of the TH1 domain restores its localization to junctions. We have also found that the Myo1e SH3 domain interacts with ZO-1, a slit diaphragm and tight junction protein, in invitro pulldown assays, which might contribute to ZO-1 exchange activity at the junctions. Another FSGS-associated Myo1e motor domain mutation (T119I) also caused mis-localization of Myo1e in the cultured mouse podocytes, suggesting loss-of-function of the motor domain mutants. We have also shown that ZO-1 is not recruited to the nascent cell-cell contacts at the same time with the Myo1e T119I mutants. Finally, by using fission yeast as a model system, we have demonstrated that human kidney disease-associated mutations in fission yeast caused defects in yeast growth and endocytosis processes. Interestingly, after analyzing the colocalization patterns between the FSGS-associated Myo1 mutants and Chaperone Rng3, we have proposed that these two kidney disease-associated mutants likely possess different disease-causing mechanisms.Above all, we have concluded that Myo1e motor domain plays an important role in its localization and activity in podocyte actin cytoskeleton, which might be the link to the disease mechanism of FSGS at the molecular level.
    • Effects of Rab4A Mutations on Mouse Behavior, mTORC1 Activity,and Surface 8Receptor/TransporterRecycling

      Perl, Andras; Winans, Thomas C (2020-10-03)
      Through studying endosomal regulation, I found that a single amino acid 47mutation (Q72L) in the Rab4A gene leads to neurological disorders in two separate 48mouse strains. In the C57Bl/6 (SLE(WT)) background,I found thatknock-in the 49Rab4A gene leads to hyperactivity, which resembles both autism spectrum 50disorders (ASD) and attention-deficit hyperactivity disorder (ADHD). On a lupus-51prone background (SLE(1.2.3)) I found thatthe same mutation led to hypoactivity, 52which indicates a more severe neuropsychiatric systemic lupus erythematosus 53(NPSLE) than SLE(1.2.3)mice with wild type Rab4A.54The same mice were studied in chapter two, where mTORC1 activity was 55confirmed to be elevated in CD4+ T cells when Rab4A was knocked-in (Rab4A(KI))56compared to Rab4A(WT) cells.In young mouse brains prior to disease onset, I found57increases of mTORC1 and oxidative stress in Rab4A(KI) brains relative to 58Rab4A(WT) brains. In the same brains, there was also a depletion of GLUT1 and 59IFNGR1.Many of these changes were absent in the adult mice, after disease had 60developed.61SLE(1.2.3) mice with the three Rab4A alleleswere treated withrapamycin or 62NAC,and brains were collected.In these brains, there wasevidence that the 63hypoactive Rab4A(KI) SLE(1.2.3) had lower mTORC1 activity than Rab4A(WT) and 64Rab4A(KO) mice.This finding indicatesdepression, which is a pattern seen in major 65depressive disorder(MDD). Depression is also a symptoms of NPSLE. Interestingly, 66rapamycin increased mTORC1 activity in theRab4A(KI)brains compared Rab4A(KI) 67mice treated with vehicle, indicating a positive effect from the drug.
    • THE EFFECTS OF VARYING ACTIN AND CAPPING PROTEIN CONCENTRATIONS ON ACTIN PATCH DYNAMICS IN FISSION YEAST

      Sirotkin; Plante, Kyle (2015)
      Actin assembly into structures called endocytic actin patches is directly responsible for driving endocytic invagination and internalization. We tested the predictions made from the mathematical modeling of the Dendritic Nucleation Model of actin assembly at sites of clathrin-mediated endocytosis in fission yeast (Berro et al.; Sirotkin et al., 2010). The model predicts that increasing the concentration of cytoplasmic actin or deleting capping protein will cause an increase in the extent and the rate of actin assembly in actin patches. Conversely, the model predicts that increasing the concentration of capping protein or decreasing the actin concentration will cause a decrease in the extent and the rate of actin assembly in actin patches. To test these predictions, we used the actin cross-linking protein, fimbrin Fim1 tagged with a fluorescent protein to measure actin patch dynamics in strains that over- or under-express actin, over-express capping protein, or have deletions of the two capping protein genes. In contrast to model predictions, we found that manipulating capping protein concentrations did not have a significant effect on the extent of actin patch assembly and affected the rates of assembly to a lesser degree than expected from the model, suggesting that capping protein is not the only factor that limits actin patch assembly. Surprisingly, changes in the concentration of actin resulted in changes in the number of patches in a cell, suggesting that the concentration of actin is more important in controlling the initiation of new patches rather than in patch assembly. Through studying the biochemical pathway of actin assembly directly in living cells, we were able to gain insights into previously under-appreciated aspects of the mechanism of actin assembly at the sites of clathrin-mediated endocytosis.
    • The Efficacy of Screencasting Technology in the Classroom.

      Fancett-Stooks, Daniel J. (2012-05-01)
      A study that investigates the efficacy of screencasts. As a tool used for instruction, screencasting can be significant in reaching out to broader ranges of learners in the classroom. Through the utilization of the screencast, the teacher can work towards compartmentalizing instruction and create a repository of lessons. This repository of screencasts can assist in present and future curriculum and lesson development. By having these screencasts available to the student, the teacher can provide a more one-toone instructional setting that will help raise the comprehension and understanding of the content that is being demonstrated.
    • Electronic Text Displays: Reading Rehabilitation of Low Vision Patients with Age-Related Macular Degeneration

      Aquilante, K. (SUNY College of Optometry, 2003-03-23)
      The purpose of this study was to investigate whether reading performance, measured in words per minute, improved during an hour of within-session practice. The reading methods were three computer-generated presentations including (1) MNREAD, a modified page format, (2) RSVP, which presents one word at a time, and (3) SCROLL, where text pans from right to left across a screen. Forty-five young readers with normal vision, forty-five elder readers with normal vision, and forty-five readers with low vision due to age-related macular degeneration read by one of these methods. None of the participants had previous experience reading with MNREAD, RSVP of SCROLL. There was little evidence that within-session practice improved performance. Only 10 of 135 participants had modest reading rate gains, and there was no statistical difference between reading method or subject group for this small subset of readers.
    • An Empirical Wi-Fi Intrusion Detection System

      Kholidy, Hisham A.; Basnet, Diwash Bikram; Kholidy, Hisham A.; Advisor (SUNY Polytechnic Institute, 2020-05)
      Today, the wireless network devices are growing rapidly, and it is of utmost importance for securing those devices. Attackers or hackers use new methods and techniques to trick the system and steal the most important data. Intrusion Detection Systems detect the attacks by inspecting the network traffics or logs. The work demonstrated the effectiveness of detecting the attacks using machine learning techniques on the AWID dataset, which is produced from real wireless network logging. The author of the AWID dataset may have used several supervised learning models to successfully detect the intrusions. In this paper, we propose a newer approach for intrusion detection model based on dense neural networks, and long short-term memory networks (LSTM) and evaluate the model against the AWID-CLS-R subset. To get the best results from the model, we applied feature selection by replacing the unknown data with the value of “none”, getting rid of all repeated values, and kept only the important features. We did preprocess and feature scaling of both training and testing dataset, additional we also change the 2-dimensional to the 3- dimensional array because LSTM takes an input of 3-dimensional array, and later we used flatten layers to change into a 2-dimensional array for output. A comprehensive evaluation of DNN and LSTM networks are used to classify and predict the attacks and compute the precision, recall, and F1 score. We perform binary classification and multiclass classification on the dataset using neural networks and achieve accuracy ranging from 86.70 % to 96.01%.
    • Employee Collaboration in Sharepoint

      Vempati, Sai Sandeep Soumithri; Chiang, Chen-Fu; Adviser; Novillo, Jorge; Reviewer; Rezk, Mohamed; Reviewer (2016-12-01)
      This project aims at developing a portal for a company’s internal needs that include leave portal, a pre-sales dashboard and a document sharing list for the employees in SharePoint Online. SharePoint Online is web based Content Management System (CMS) provided by Microsoft. Microsoft introduced SharePoint in 2001 which was an instant winner. It had all the features that are needed for storage and collaboration. SharePoint later on evolved into two major versions, namely, On-premise and Cloud version. SharePoint the cloud version proved to be a feasible CMS for start-ups and small companies. As the usage of SharePoint Online has minimised the burden maintenance of servers and administration more companies started using SharePoint. The utility of SharePoint has caught the attention of many companies lately. It has scaled up to, 75000 organisations saving 160 million users [8]. The usage of SharePoint made companies develop portals that are interactive and act as platforms for collaboration and exchange of information. The workflow automation provided by SharePoint helps in simplifying the business process management. Web technologies can be used to develop the portal in a user friendly and responsive manner. In this project, a portal is developed that mainly has three functionalities – a leave application platform, a dashboard for Presales and a list that helps sharing of information. The leave application feature is based on the workflow automation service provided by SharePoint in which the user can request concerned manager for a leave approval. The whole process of approval is automated in the portal. The Presales dashboard option helps in viewing data related to projects that can be used to develop reports by the Presales team of a company. The data is shown in various forms suitable for easy understanding using web parts in the dashboard. A list that demonstrates file approval is included in the portal.
    • Employing User-Centered Design to Accelerate the Construction of a Business Intelligence Dashboard

      Obermaier, Joseph F.; Stam, Kathryn; Thesis Advisor; Lizardi, Ryan; Second Reader (2018)
      Providing real-time data to decision makers has become a key component in the management of complex systems. The most common visualization for this type of data is the electronic dashboard, which, like the instrument panel on an airplane, displays critical data in a well-designed, easily understood, manner. The challenge for designers of such systems today is not just to find a way to effectively communicate information to decision makers, but to do so in an environment that demands an ever more rapid development cycle. The intent of this paper is to review several studies and present a hypothetical project with an eye toward uncovering just how user-centered design can afford a designer an opportunity to develop such an intranet dashboard at an accelerated pace.
    • Enhancing Community and Creating Unity Using a Mobile Application

      Ellis, Kayla; Stam, Kathryn; Thesis Advisor; Lizardi, Ryan; Second Reader (SUNY Polytechnic Institute, 2019-05)
      This project involves the creation of a prototype mobile application for a multi-cultural community center in Utica, NY, the Midtown Utica Community Center (MUCC). It is an inclusive multicultural and refugee-friendly space for members to come and join in on different programs, activities, and services that the center offers. Hundreds of families utilize the open and welcoming space on a weekly basis and it serves as a place for them to congregate and come together. It is a place filled with heritage and members who are friends, but see themselves as family. This is where the idea for a mobile application stemmed from. This mobile application would be used by both members and nonmembers of the community center, as well as the staff, executive board, and volunteers. The goal of the application is to enhance the sense of community and bring a feeling of unity to the members of the organization. In this unique scenario, since the application is being built for a community center, the sense of “community” is already present—the utilization of technology such as a mobile application will only enhance, build upon, and create a sense of unity for the current and soon-to-be members of this organization. For the most part, members of this center are made up of various youth age groups. In this paper, I will explore research that has been conducted on the use of mobile technology and applications by youth as well as ways to keep them engaged and interacting with an application on a daily basis. Another area for exploration is the idea of using the application to an application on a daily basis. Another area for exploration is the idea of using the application to be in two places at once, to communicate with peers even though they may not physically be present at the center.
    • Enhancing the Effectiveness of Software Test Automation

      Jansing, David; Novillo, Jorge; Adviser; Cavallo, Roger; Reviewer; Spetka, Scott; Reviewer (2015-12-01)
      Effective software testing can save money and effort by catching problems before they make it very far through the software development process. It is known that the longer a defect remains undetected, the more expensive it is to fix. Testing is, therefore a critical part of the development process. It can also be expensive and labor intensive, particularly when done by hand. It is estimated that the total effort testing software consumes at least half of a project’s overall labor. Automation can make much of the testing an organization does more accurate and cheaper than merely putting several people in a room and having them run tests from a paper script. It also frees the testing staff to do more specific and in-­‐depth testing than would otherwise be possible. This paper focuses mainly on software test automation techniques and how automation can enhance the efficiency of a software team as well as the quality of the final product.
    • Environmental risk factors for attention‐deficit hyperactivity disorder

      Banerjee, Tania Das; Middleton, Frank; Faraone, Stephen V. (Wiley, 2007-06-15)
      Attention-deficit hyperactivity disorder (ADHD) is the most common cognitive and behavioural disorder diagnosed among school children. It is characterized by deficient attention and problem solving, along with hyperactivity and difficulty withholding incorrect responses. This highly prevalent disorder is estimated to affect 5–10% of children and in many cases, persists into adulthood, leading to 4% prevalence among adults. Converging evidence from epidemiologic, neuropsychology, neuroimaging, genetic and treatment studies shows that ADHD is a valid medical disorder. The majority of studies performed to assess genetic risk factors in ADHD have supported a strong familial nature of this disorder. Family studies have identified a 2- to 8-fold increase in the risk for ADHD in parents and siblings of children with ADHD. Various twin and adoption studies have also highlighted the highly genetic nature of ADHD. In fact the mean heritability of ADHD was shown to be 0.77, which is comparable to other neuropsychiatric disorders such as schizophrenia or bipolar disorder. However, several biological and environmental factors have also been proposed as risk factors for ADHD, including food additives/diet, lead contamination, cigarette and alcohol exposure, maternal smoking during pregnancy, and low birth weight. Many recent studies have specifically examined the relationships between ADHD and these extraneous factors. This review describes some of these possible risk factors.
    • Ethanol-Induced Effects of the Microtranscriptome on Natural Gene Expression

      Middleton, Frank; Ignacio, Cherry Mae Gonzalez
      Reliable, minimally invasive biomarkers that predict the extent of alcoholism-induced CNS damage are currently lacking. This limits the selection of rational interventions and hampers the ability to gauge therapeutic effects. Developing biomarkers that indicate early CNS damage may prove useful in deterring the emergence of alcohol use disorders (AUDs). Extracellular microRNAs (miRNAs) can be informative molecular indicators of neuronal gene expression alterations. They repress large fractions of protein-coding genes and are highly-involved in intercellular signaling between both proximal and distal neurons. This work has focused on (1) examining whether extracellular miRNAs in the serum of individuals diagnosed with AUDs can be used as biomarkers of alcohol-induced brain damage, (2) determining in vivo the ethanol-inducedeffects imparted by miRNAs and their targets in the brain, (3) evaluating their role ininterventions that can reverse behavioral impairment and (4) testing the ability of extracellular miRNAs to transfer ethanol-induced pathologies to ethanol-naive cells. There are five major findings from this work. First, two independent quantification technologies demonstrated comparable differences in miRNA expression levels betweenAUDs and controls and revealed significant correlations between candidate miRNA biomarkers and medical, neuroimaging and drinking parameters. Second, in rats manymiRNAs significantly altered by ethanol in the hippocampus following maternal or postnatal exposure were also changed in the serum. Moreover, postnatal consumption activated cell-cycle pathways in the hippocampus while maternal exposure affected unfolded protein response pathways in adolescent offspring. Third, the lack of social motivation seen following fetal exposure was reversed as a result of social enrichment. Analysis of the integrated data in the amygdala and ventral striatum revealed several functional gene networks whose activation patterns following fetal ethanol exposure were reversed by social enrichment. Fourth, transfer of purified exosomes from ethanol-exposed to ethanol-naive cells conferred many gene expression changes consistent with ethanol exposure. Lastly, examination of all the data revealed consistent changes in miRNAs that independently converged on cell death, cell proliferation and cell cycle regulatory processes, regardless of the species, paradigm and source. The findings in this work illustrate the utility of miRNAs as peripheral biomarkers of AUDs and suggest novel epigenetic mechanisms affected by alcohol.