• Data Journalism Meets Information Design: Creating A Complex Infographic About The Yarnell Hill Wildfire

      Godoy, Katelyn (2015-05-01)
      In June and July 2013, a large-scale wildfire, known as the Yarnell Hill wildfire, tore through the Yarnell community in Arizona. The fire claimed the lives of 19 firefighters—the greatest loss of firefighter lives since the September 11 World Trade Center attacks. This project, which details the events of the wildfire and its aftermath in a complex infographic, is an example of data journalism and complements the reporting completed by The Arizona Republic. This paper explores the emerging field of data journalism within information design and provides an overview of the process used to create and design this project. In addition, it summarizes data collection techniques and application of graphic design best practices. It also details directions for future design opportunities related to this topic.
    • Data Journalism Meets Information Design: Creating A Complex Infographic About The Yarnell Hill Wildfire

      Godoy, Katelyn (2015-05-01)
      In June and July 2013, a large-scale wildfire, known as the Yarnell Hill wildfire, tore through the Yarnell community in Arizona. The fire claimed the lives of 19 firefighters—the greatest loss of firefighter lives since the September 11 World Trade Center attacks. This project, which details the events of the wildfire and its aftermath in a complex infographic, is an example of data journalism and complements the reporting completed by The Arizona Republic. This paper explores the emerging field of data journalism within information design and provides an overview of the process used to create and design this project. In addition, it summarizes data collection techniques and application of graphic design best practices. It also details directions for future design opportunities related to this topic.
    • Data Mining and Bi Data Warehousing Based Implementation for a Random Film Studio

      Bonthi, Sneha; Andriamanalimanana, Bruno; Adviser; Rezk, Mohamed; Reviewer; Reale, Michael; Reviewer (2016-12-01)
      The purpose of this report is to study a dataset of movies and analyse the possibility and feasibility of implementing a data warehousing or a data mining application to improve analytics and decision making. The project report talks about the raw data originating from the data collection centres and box offices which can be modelled and transformed into a specific format and structure that would help the business analysts in identifying patterns and trends so as to take important business decisions. The report explores the benefits of extracting, transforming and loading this raw data into a dimensional model. According to the proposed implementation, one can create a reporting layer to perform aggregations and grouping them by various attributes like date, genre, actor and country and present them using dashboards and reports to enable better decision making. This single point of data, which is the result of data mining activity, can be shared and brainstorming sessions can then be carried out to infer priceless market information and effectively utilize time and efforts to maximize profits.
    • Data Mining: Privacy Preservation in Data Mining Using Perturbation Techniques

      Patel, Nikunjkumar; Sengupta, Sam; Adviser; Andriamanalimanana, Bruno; Reviewer; Novillo, Jorge; Reviewer (2015-05-06)
      In recent years, data mining has become important player in determining future business strategies. Data mining helps identifying patterns and trends from large amount of data, which can be used for reducing cost, increasing revenue and many more. With increased use of various data mining technologies and larger storage devices, amount of data collected and stored is significantly increased. This data contains personal information like credit card details, contact and residential information, etc. All these reasons have made it inevitable to concentrate on privacy of the data. In order to alleviate privacy concerns, a number of techniques have recently been proposed to perform the data mining in privacy preserving way. This project briefs about various data mining models and explains in detail about perturbation techniques. Main objective of this project is to achieve two things. First, preserve the accuracy of the data mining models and second, preserve the privacy of the original data. The discussion about transformation invariant data mining models has shown that multiplicative perturbations can theoretically guarantee zero loss of accuracy for a number of models.
    • Data-driven clustering identifies features distinguishing multisystem inflammatory syndrome from acute COVID-19 in children and adolescents.

      Geva, Alon; Patel, Manish M; Newhams, Margaret M; Young, Cameron C; Son, Mary Beth F; Kong, Michele; Maddux, Aline B; Hall, Mark W; Riggs, Becky J; Singh, Aalok R; et al. (2021-08-31)
      Background: Multisystem inflammatory syndrome in children (MIS-C) consensus criteria were designed for maximal sensitivity and therefore capture patients with acute COVID-19 pneumonia. Methods: We performed unsupervised clustering on data from 1,526 patients (684 labeled MIS-C by clinicians) <21 years old hospitalized with COVID-19-related illness admitted between 15 March 2020 and 31 December 2020. We compared prevalence of assigned MIS-C labels and clinical features among clusters, followed by recursive feature elimination to identify characteristics of potentially misclassified MIS-C-labeled patients. Findings: Of 94 clinical features tested, 46 were retained for clustering. Cluster 1 patients (N = 498; 92% labeled MIS-C) were mostly previously healthy (71%), with mean age 7·2 ± 0·4 years, predominant cardiovascular (77%) and/or mucocutaneous (82%) involvement, high inflammatory biomarkers, and mostly SARS-CoV-2 PCR negative (60%). Cluster 2 patients (N = 445; 27% labeled MIS-C) frequently had pre-existing conditions (79%, with 39% respiratory), were similarly 7·4 ± 2·1 years old, and commonly had chest radiograph infiltrates (79%) and positive PCR testing (90%). Cluster 3 patients (N = 583; 19% labeled MIS-C) were younger (2·8 ± 2·0 y), PCR positive (86%), with less inflammation. Radiographic findings of pulmonary infiltrates and positive SARS-CoV-2 PCR accurately distinguished cluster 2 MIS-C labeled patients from cluster 1 patients. Interpretation: Using a data driven, unsupervised approach, we identified features that cluster patients into a group with high likelihood of having MIS-C. Other features identified a cluster of patients more likely to have acute severe COVID-19 pulmonary disease, and patients in this cluster labeled by clinicians as MIS-C may be misclassified. These data driven phenotypes may help refine the diagnosis of MIS-C.
    • De-anonymizing Social Network Neighborhoods Using Auxiliary and Semantic Information

      Morgan, Steven Michael; Novillo, Jorge; Adviser; Andriamanalimanana, Bruno; Reviewer; Reale, Michael; Reviewer (2015-12-11)
      The increasing popularity of social networks and their progressively more robust uses provides an interesting intersection of data. Social graphs have been rigorously studied for de-anonymization. Users of social networks will provide feedback to pages of interest and will create a vibrant profile. In addition to user interests, textual analysis provides another feature set for users. The user profile can be viewed as a classical relational dataset in conjunction with graph data. This paper uses semantic information to improve the accuracy of de-anonymizing social network data.
    • Deciphering a hippocampus to hypothalamus feeding circuit via the septal nucleus.

      Yang, Yunlei; Sweeney, Patrick (2017)
      The neural circuits controlling feeding are concentrated in the hypothalamus and hindbrain. These circuits primarily control homeostatic feeding behavior, which can be broadly defined as increasing feeding in response to hunger or decreasing feeding in response to satiety. However, non-homeostatic factors, such as the emotional state of an animal, can also profoundly affect feeding behavior. Therefore, the current thesis project sought to determine how primary emotion centers in the brain influence the known homeostatic feeding circuitry in the hypothalamus. In particular, given that ventral hippocampus (vHPC) and septum are involved in emotional processes, influence feeding behavior, and are anatomically connected to hypothalamic feeding circuitry, this dissertation aimed to determine the cell-types in vHPC and septum that control feeding and to functionally connect these cell-types to the primary feeding circuitry located in the hypothalamus. To accomplish these central aims, chemogenetic and optogenetic approaches were utilized to selectively manipulate neural activity within distinct ventral hippocampal and septal cell types and neural circuits. These approaches were complemented by traditional anterograde and retrograde tracing techniques and chemo/optogenetic circuit mapping approaches to define the neural circuits responsible for vHPC and septal control of feeding behavior. We find that chemogenetic activation of ventral hippocampal glutamate neurons reduces feeding, while inhibition facilitates feeding. We further dissect a functional neural circuit pathway from ventral hippocampus to lateral septum that is sufficient to suppress feeding behavior. Within the septum, both chemo/optogenetic activation of septal GABAergic neurons reduces feeding, while inhibition of these neurons increases food intake. Utilizing optogenetic circuit manipulation approaches, we demonstrate that septal GABAergic neurons reduce feeding, at least in part, by projecting to hyperphagia-inducing GABAergic neurons located within the lateral hypothalamus. Taken together, our findings expand upon the known roles for ventral hippocampus and septum in energy homeostasis by providing the specific cell-types and neural circuits governing vHPC and septal control of feeding behavior. Given the role for ventral hippocampus and septum in emotional processes and energy homeostasis, we propose that the described vHPC and septal circuits represent promising neural circuits for investigating interactions between feeding, emotional state, and motivated behavior.

      Lewis, Kate; Hilinski, William (2016)
      The correct specification of neurotransmitter phenotypes is crucial for properly functioning neuronal circuitry. Neurons specify their neurotransmitter phenotypes via transcription factors that they express as they differentiate. Often, transcription factors that specify neurotransmitter phenotypes are expressed in multiple populations with the same neurotransmitter phenotype. Since, the transcription factors that specify this characteristic are not yet known for all spinal cord glutamatergic populations, we identified additional transcription factors expressed at relatively higher levels in glutamatergic neurons compared to inhibitory neurons. We have functionally tested three of these (Lmx1bb, Skor1a and Skor1b) to determine if they are required for correct spinal, glutamatergic phenotypes. We demonstrate that Lmx1b likely maintains a subset of glutamatergicphenotypes in the spinal cord. In lmx1bb mutant embryos, the number of cells that initially express glutamatergic markers are unchanged but become reduced at 36 h and to a greater degree at 48 h. In contrast, we observe no changes in the total number of dI5 or V0v neurons, which express lmx1bb,nor do we detect elevated levels of apoptosis between 36 h and 48 h in lmx1bb mutants. Lastly, we show that at least some of the cells that lose their glutamatergic neurotransmitter phenotype are likely to be V0v cells.Additionally, we demonstrate that skor1a and skor1b are expressed predominantly by glutamatergic spinal interneurons, many of which are V0v neurons. When skor1a and skor1b are knocked-down, we observe a significant reduction in the number of glutamatergic neurons and no change in the number of inhibitory neurons suggesting that these genesmay be required to specify the glutamatergic neurotransmitter phenotype of a subset of spinal neurons. In parallel studies, it was shown that evx1 and evx2, genes expressed exclusively by V0v spinal neurons, are required to specify the V0v glutamatergic phenotype. Interestingly, we show that lmx1bb, skor1a and skor1b require evx1 and evx2 for their expression. In summary, these results suggest that skor1, skor1b and lmx1bb may function downstream of evx1 and evx2 to specify and/ormaintain the glutamatergic neurotransmitter phenotype ofat least a subset of V0v neurons.
    • The Deep Space Network - A Technology Case Study and What Improvements to the Deep Space Network are Needed to Support Crewed Missions to Mars?

      Falke, Prasad; Hash, Larry; Advisor; Marsh, John; Reviewer; White, Joshua; Reviewer; Climek, David; Reviewer; Kwiat, Kevin; Reviewer (2017-05-28)
      The purpose of this thesis research is to find out what experts and interested people think about Deep Space Network (DSN) technology for the crewed Mars mission in the future. The research document also addresses possible limitations which need to be fix before any critical missions. The paper discusses issues such as: data rate, hardware upgrade and new install requirement and a budget required for that, propagation delay, need of dedicated antenna support for the mission and security constraints. The Technology Case Study (TCS) and focused discussion help to know the possible solutions and what everyone things about the DSN technology. The public platforms like Quora, Reddit, StackExchange, and Facebook Mars Society group assisted in gathering technical answers from the experts and individuals interested in this research.
    • Deficient Emotional Self-Regulation and Adult Attention Deficit Hyperactivity Disorder: A Family Risk Analysis

      Surman, Craig B.H.; Biederman, Joseph; Spencer, Thomas; Yorks, Dayna; Miller, Carolyn A.; Petty, Carter R.; Faraone, Stephen V. (American Psychiatric Association Publishing, 2011-06)
      Objective: A growing body of research suggests that deficient emotional self-regulation (DESR) is prevalent and morbid among patients with attention deficit hyperactivity disorder (ADHD). Family studies provide a method of clarifying the co-occurrence of clinical features, but no family studies have yet addressed ADHD and DESR. Method: Participants were 83 probands with and without ADHD and 128 siblings. All were assessed for axis I DSM-IV conditions with structured diagnostic interviews. The authors defined DESR in adult probands and siblings using items from the Barkley Current Behavior Scale. Analyses tested hypotheses about the familial relationship between ADHD and DESR. Results: Siblings of ADHD probands were at elevated risk of having ADHD, irrespective of the presence or absence of DESR in the proband. The risk for DESR was elevated in siblings of ADHD plus DESR probands but not in siblings of ADHD probands. ADHD and DESR cosegregated in siblings. The risk for other psychiatric disorders was similar in siblings of the ADHD proband groups. Conclusions: The pattern of inheritance of ADHD with DESR preliminarily suggests that DESR may be a familial subtype of ADHD. Our data suggest that DESR is not an expression of other axis I DSM-IV disorders or of nonfamilial environmental factors. The authors cannot exclude contribution of non-axis-I DSM-IV disorders to risk for DESR and cannot determine whether the cosegregation of ADHD in DESR within families is a result of genes or familial environmental risk factors. Further investigation of DESR and its correlates and treatment both in and outside the context of ADHD is warranted.
    • Defining the Determinants of the Bok-IP3R Interaction and the Bok Interactome

      Richard Wojcikiewicz; Szczesniak, Laura (2021)
      Bok is a Bcl-2 protein family member that is often grouped with the pro-apoptotic family members Bax and Bak due to high sequence homology and because exogenously overexpressed Bok induces apoptosis by causing mitochondrial outer membrane permeabilization. However, the cellular roles of Bok remain unclear, as Bok KO cell lines and mice have failed to demonstrate a significant phenotype under normal conditions. Our lab discovered that Bok interacts with inositol 1,4,5-trisphosphate receptors (IP3Rs), tetrameric Ca2+ channels found in the ER membrane of mammalian cells that play an integral role in cell signaling. While other Bcl-2 family members have been reported to weakly interact with IP3Rs, the Bok-IP3R interaction is much more efficient, with essentially all cellular Bok constitutively bound to IP3Rs. We have generated full-length IP3R1 mutants that resolve the Bok-binding region to a small, unstructured loop in the cytosolic region of IP3R1 between _ helices 72 and 73. Additional bioinformatic analysis has revealed that the Bok-IP3R interaction is likely dependent upon helical and dynamic determinants within this loop. Interestingly, Bok KO cell lines demonstrate mitochondrial fragmentation and only minor changes in mitochondrial bioenergetics. We have investigated the role of Bok in mitochondrial dynamics through an in vivo proximity labeling technique known as TurboID. A TurboID-Bok fusion protein expressed in Bok KO HeLas has identified several mitochondrial fission proteins through mass spectroscopy analysis, suggesting that Bok acts at mitochondria-ER contact sites to inhibit fission, and this function may be independent of the Bok-IP3R interaction. The results provided from binding studies and proximity labeling have furthered our knowledge of the Bok-IP3R interaction and of Bok itself to better define, or re-define, the role of Bok within the cell. Understanding how and why these interactions occur will help us further understand fundamental cellular processes in health and human disease.
    • Deletion at the SLC1A1 glutamate transporter gene co-segregates with schizophrenia and bipolar schizoaffective disorder in a 5-generation family

      Myles-Worsley, Marina; Tiobech, Josepha; Browning, Sharon R.; Korn, Jeremy; Goodman, Sarah; Gentile, Karen; Melhem, Nadine; Byerley, William; Faraone, Stephen V.; Middleton, Frank A. (Wiley, 2013-01-22)
      Growing evidence for genetic overlap between schizophrenia (SCZ) and bipolar disorder (BPD) suggests that causal variants of large effect on disease risk may cross traditional diagnostic boundaries. Extended multigenerational families with both SCZ and BPD cases can be a valuable resource for discovery of shared biological pathways because they can reveal the natural evolution of the underlying genetic disruptions and their phenotypic expression. We investigated a deletion at the SLC1A1 glutamate transporter gene originally identified as a copy number variant exclusively carried by members of a 5-generation Palauan family. Using an expanded sample of 21 family members, quantitative PCR confirmed the deletion in all seven individuals with psychosis, three “obligate-carrier” parents and one unaffected sibling, while four marry-in parents were non-carriers. Linkage analysis under an autosomal dominant model generated a LOD-score of 3.64, confirming co-segregation of the deletion with psychosis. For more precise localization, we determined the approximate deletion end points using alignment of next-generation sequencing data for one affected deletion-carrier and then designed PCR amplicons to span the entire deletion locus. These probes established that the deletion spans 84,298 bp, thus eliminating the entire promoter, the transcription start site, and the first 59 amino acids of the protein, including the first transmembrane Na2+/dicarboxylate symporter domain, one of the domains that perform the glutamate transport action. Discovery of this functionally relevant SLC1A1 mutation and its co-segregation with psychosis in an extended multigenerational pedigree provides further support for the important role played by glutamatergic transmission in the pathophysiology of psychotic disorders. © 2013 Wiley Periodicals, Inc.
    • Department of Communications and Humanities Certificate of Approval

      Thoryk, Dennis (2012-05-01)
      Abstract not present in the Thesis

      Stam, Kathryn; Thesis Advisor; Lizardi, Ryan; Second Reader; Hung, Li (2020-07)
      The primary objectives of information design are to develop information artifacts, design interactions with technologies, and enable people to navigate in physical and virtual spaces. The aims are to improve efficiency, enhance productivity, or to solve problems through the knowledge produced by the information products. The goal of this project is to present various avenues through which information design could expand its horizons. In conjunction with this paper, the presentation slides: “Synchronizing Creativity in Smart Cities around the World: The Creative Way of Life,” demonstrate that when combining the literature in English with information design and technological abilities, innovation and creativity can emerge. Institutions such as International Organizations, Standards-setting organizations, research agencies, and the U.S. agenda on innovation are discussed. Internet of Things, Big Data, Cyber-Physical Systems, Smart Cities, and the creative economy under the new name of “Orange Economy” are explored. I conclude with a personal reflection on the journey in producing this project relative to the power of the literature in English, including what “smartness” could mean in the field of information design as well as in humanity.
    • Design and Characterization of Proteins Rationally Engineered to Domain Swap by Mutually Exclusive Folding

      Loh, Stewart; Karchin, Joshua Michael (2016)
      Domain swapping is a mechanism for proteins to form dimers and higher order oligomers through the exchange of a section of their 3D structures. The backbone peptides of domain swapped oligomers are intertwined, but their 3D structures remain identical to their monomeric state, except for where they cross-over, termed a hinged region. We have developed a technique to engineer domain swapping interfaces with mutually exclusive folding (MEF). MEF achieves this by inserting a ‘lever’ protein into the surface loops of a host ‘target’ protein to form a target-lever fusion. This target-leveris conformationally strained with the lever and the target in a thermodynamic tug-of-war. When the lever is folded, the long distance between its N- and C-termini stretches apart the target and splits it in half. Conversely, when the target is folded, the short length of the loop where the lever was inserted compresses the lever and unfolds it. Domain swapping provides an escape from this tug-of-war as it allows the split target to refold and bypass the conformational strain. Because the lever is external to the target, adjusting the stability of the lever, through well-established thermodynamic principles, allows the propensity for domain swapping to be modulated without affecting the binding interface. This enables the design of “triggerable” levers which can reversibly induce domain swapping in response to a signal. Further, we can use domain swapping to turn the function of a target domain on and off. Two target-lever constructs are created with functional mutants in the target domain, one N-terminal to the lever and the other one C-terminal to the lever. Individually, both of these mutants are inactive, however if they are mixed and allowed to domain swap, then up to half of the target domains can swap out the functional mutations into the native active form. This bimolecular system in combination with induced domain swapping enables the design of modular bioswitches and biosensors.
    • Design and Implement a Photo Gallery website for Snapshots of Resettlement: A Digital Showcase of Images and Stories of Resettled Refugees in Utica, NY

      Cohen, Douglas (2014-05-01)
      The concept for this project originated from the acceptance of Dr. Kathryn Stam's proposed photos essay idea of Bhutanese-Nepali refugees in Utica, NY to the journal Himalaya (http://digitalcommons.macalester.edu/himalaya). The Snapshots of Resettlement project is an extension of the concepts in the Refugees Starting Over in Utica, NY website (http://www.startingoverutica.com) but has been implemented such that it is an independent entity. This paper will explore the technology platforms used to create the Snapshots of Resettlement online photo gallery. It will also provide an overview of design and implementation decisions made through the duration of this project. In addition, this paper will offer details on select information design principles used in this project’s implementation.
    • Design and Implement a Small Business with Digital Marketing Be Happy, Se Feliz: Find Your Happiness and Learn to Put It First

      Stam, Kathryn; Thesis Advisor; Lizardi, Ryan; Second Reader; Flores, Jacqueline (2021-05)
      The purpose of this study was to identify and organize a plan to market an Airbnb vacation rental property in the Caribbean by a single female parent in her 30’s. The study includes research on Universal Design Uses for Marketing in Tourism or Travel, Digital Marketing/Social Media Marketing (including for travel sites) and Small business and branding development. The design of the study includes a proposal, methodology for the design and the production of digital artifacts including branding development with personal website and social media sites. This capstone project was developed and implemented using graphic design concepts, digital photography’s composition techniques, user experience considerations, evaluation of select technologies and select Universal Principles of Design. Throughout the research and design process, similar social media accounts and websites were reviewed to identify likeability, professionalism and conclusions were drawn for why some sites were liked or followed more than others. While viewing sites, session duration, or length of time spent, was also taken into consideration. The successful concepts on these sites were also taken into consideration or applied in the production of web-based marketing materials and platforms to support marketing the rental property in the Caribbean for this capstone. Branding was a major component of successful marketing for all sites. In summary, leveraging many SUNY Polytechnic Information Design and Technology course concepts from Digital Photography, User Experience, Graphic Design and Evaluating Information Technology a new brand was formed: Be Happy, Se Feliz. Branding was designed utilizing elements from graphic design and digital photography, from development of vision and mission statements, audience focus, logo design, typography selection, color palette selection and site development. Several concepts from “Universal Principles of Design” (Lidwell et al., 2010) were reviewed and utilized in the design for projecting the users into an idealistic vacation environment. This was the primary focus of the marketing techniques utilized. Final selection of the tools and platforms used were conducted by utilizing techniques from Evaluating Information Technology.
    • Design and Review of Multi-Media Marketing for Community Project: Refugees Starting Over in Utica, NY

      Reilly, Kathryn (2013-05-01)
      This project was the design and implementation of multi-media marketing and promotion techniques for the cultural and community project Refugees Starting Over in Utica, NY (“Starting Over”). Starting Over is a SUNYIT sponsored project that set out to highlight refugee resettlement in Utica through a series of events and to create a community of practice through its web presence. This paper will first explore the refugee population in Utica. Second, the details of the project will be discussed. Lastly, the different multi-media tools that were used will be examined. These tools will be measured for effectiveness. Successes with the multimedia marketing elements will be shown.
    • Design of an Online Technical Communication Course Using the Open SUNY Online Course Quality Rubric

      Brierley, Sean; Stam, Kathryn; Thesis Advisor; Lizardi, Ryan; Second Reader (SUNY Polytechnic Institute, 2019-05)
      This project is a one-semester, online technical communication class for undergraduates at a four-year university. The audience includes students who are taking the class to learn about writing but who generally have majors unrelated to technical communication. The online class will use best practices in course delivery and will support a constructivist theory of learning, based on peer-to-peer, as well as peer-to-instructor, interaction. Writing and communication best practices will make extensive use of revision based on peer and instructor review. Importantly, this design of the class will make use of the Open SUNY Online Course Quality Review (OSCQR) Rubric and Process (“About OSCQR,” n.d.). The intent of this project is to deliver a live product that can be accessed through the Internet and used out of box with little revision almost immediately. A representative, functional Moodle class will be available at https://brierleynet.com, and this will be ready for roll-out before the fall 2019 semester.