RSS 1.0Doctoral Degree Granting Institutions
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All campuses are research institutions and offer bachelor's, master's and doctoral degrees through a broad range of academic programs. Undergraduate research and honors programs provide students with opportunities to interact one-on-one with renowned national and international faculty.
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Agonal factors distort gene-expression patterns in human postmortem brainsAgonal factors, the conditions that occur just prior to death, can impact the molecular quality of postmortem brains, influencing gene expression results. Nevertheless, study designs using postmortem brain tissue rarely, if ever, account for these factors, and previous studies had not documented nor adjusted for agonal factors. Our study used gene expression data of 262 samples from ROSMAP with the following terminal states recorded for each donor: surgery, fever, infection, unconsciousness, difficulty breathing, and mechanical ventilation. Performed differential gene expression and weighted gene co-expression network analyses (WGCNA), fever and infection were the primary contributors to brain gene expression changes. Fever and infection also contributed to brain cell-type specific gene expression and cell proportion changes. Furthermore, the gene expression patterns implicated in fever and infection were unique to other agonal factors. We also found that previous studies of gene expression in postmortem brains were confounded by variables of hypoxia or oxygen level pathways. Therefore, correction for agonal factors through probabilistic estimation of expression residuals (PEER) or surrogate variable analysis (SVA) is recommended to control for unknown agonal factors. Our analyses revealed fever and infection contributing to gene expression changes in postmortem brains and emphasized the necessity of study designs that document and account for agonal factors.
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Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorderAttention-Deficit/Hyperactivity Disorder (ADHD) is a childhood psychiatric disorder often comorbid with disruptive behavior disorders (DBDs). Here, we report a GWAS meta-analysis of ADHD comorbid with DBDs (ADHD + DBDs) including 3802 cases and 31,305 controls. We identify three genome-wide significant loci on chromosomes 1, 7, and 11. A meta-analysis including a Chinese cohort supports that the locus on chromosome 11 is a strong risk locus for ADHD + DBDs across European and Chinese ancestries (rs7118422, P = 3.15×10-10, OR = 1.17). We find a higher SNP heritability for ADHD + DBDs (h2SNP = 0.34) when compared to ADHD without DBDs (h2SNP = 0.20), high genetic correlations between ADHD + DBDs and aggressive (rg = 0.81) and anti-social behaviors (rg = 0.82), and an increased burden (polygenic score) of variants associated with ADHD and aggression in ADHD + DBDs compared to ADHD without DBDs. Our results suggest an increased load of common risk variants in ADHD + DBDs compared to ADHD without DBDs, which in part can be explained by variants associated with aggressive behavior.
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Comorbidity of ADHD and adult bipolar disorder: A systematic review and meta-analysisAttention-deficit / hyperactivity disorder (ADHD) and Bipolar Disorder (BD) are common mental disorders with a high degree of comorbidity. However, no systematic review with meta-analysis has aimed to quantify the degree of comorbidity between both disorders. To this end we performed a systematic search of the literature in October 2020. In a meta-analysis of 71 studies with 646,766 participants from 18 countries, it was found that about one in thirteen adults with ADHD was also diagnosed with BD (7.95 %; 95 % CI: 5.31-11.06), and nearly one in six adults with BD had ADHD (17.11 %; 95 % CI: 13.05-21.59 %). Substantial heterogeneity of comorbidity rates was present, highlighting the importance of contextual factors: Heterogeneity could partially be explained by diagnostic system, sample size and geographical location. Age of BD onset occurred earlier in patients with comorbid ADHD (3.96 years; 95 % CI: 2.65-5.26, p < 0.001). Cultural and methodological differences deserve attention for evaluating diagnostic criteria and clinicians should be aware of the high comorbidity rates to prevent misdiagnosis and provide optimal care for both disorders.
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Technology Case Study in Storage Area NetworksIn today's world we need immediate access to data. The demand for networked data access has increased exponentially in the last 20 years. With that demand the importance and volume of networked data has also grown exponentially. The speed at which the data can be accessed has increased and with that the data has moved from individual workstations to a networked location. Over the last decade there has been a trend to move mission critical data away from individual workstations to a centralized data center. A centralized data center removes the location constraint for accessing the data. If critical data is stored on individual servers, a failure will cause the data to be inaccessible. Today, mission critical applications are spanned over multiple servers for redundancy. With this topology, having the data in a central location allows the individual servers to better work with data. With the addition of virtualization, servers can be moved online from one physical server to another. If the data is centralized, it can be presented to all hosts in the cluster. This allows servers to move efficiently between hosts without losing access to the critical data. Many businesses in various industries like finance, airline, hospital, research, etc. depend on the speed and secure availability of their centralized data to function efficiently.
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Bioengineered Platforms for Human Stem Cell-Based Diagnostic and Therapeutic InterventionsHuman stem cells offer an unprecedented ability to restore function lost through disease or injury by providing options for cell therapies and regenerative medicine. Two hurdles that delay greater clinical use of stem cells are production of differentiated therapeutic cells in large-scale platforms and the challenge of choosing the optimum cell type and delivery method for cell therapy that is optimized for cell-cell signaling in the therapeutic microenvironment. In my thesis work I investigated different bioengineered platforms in combination with human stem cell technology to mass produce functional hiPSC-derived beta islets in a miniature bioreactor and study cytokine release from multipotent and differentiated hiPSC-derived neural stem cells as neural rosettes and their dissociated cells or differentiating inhibitory and excitatory neurons alone and in mixed cultures applying a neural cell-cell interaction microchip (NCCIM) with features developed specifically for these studies. My work has further expanded the application of hiPSC-derived neurons in an in vitro model of traumatic brain injury. In this study a hybrid culture of hiPSC-derived excitatory pyramidal neurons, inhibitory GABAergic interneurons and immortalized human microglia are being evaluated for secreted cytokines under healthy and stretch injured induced conditions. One of the challenges of TBI is the inability to yet effectively and with minimal invasiveness track changes following injury that may indicate healing or deterioration and an in vitro model is one important contribution to identifying biomarkers.
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Utilizing the VARK Learning Modalities to Include Learner Preferences in the Open SUNY Course Quality Review RubricThis project is directed to the SUNY online learning (eLearning) courses which utilize OSCQR (Open SUNY Online Course Quality Review) rubric and process as course assistance for professors. The audience includes online learners at the graduate and undergraduate level. This project is designed to focus on the learner preferences of online graduate and undergraduate students. To assist instructors, this project offers a demonstration on how to offer learner preference modalities as well as learner preference assessment questionnaire via the VARK website (https://vark-learn.com/).
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Digital Storytelling with Infographics: Celebrating the Negro Leagues Using 21st Century ToolsVisual communication is more prevalent today than it ever has been in the past. Specifically, thanks to cell phones, tablets, and other smart devices, digital platforms have seen the greatest increase of visual use and show no signs of slowing down. However, with this increase comes more competition to stand out and be heard. Despite the messaging being more accessible than ever, there is a large chasm between what messaging is communicated, and how much it is viewed, understood, and retained by the audience. Thankfully designers have many options at their disposal for standing out amidst the noise. One of the most prominent of these is the infographic: a communication method that was designed for print but perfected on digital platforms. This study is designed to explain the role that infographics play for designers and storytellers. It will explore how infographics can attract a larger audience, communicate a complex idea in an easy to understand nature, and ultimately prove to be more memorable through the blending of images, text, and data into one coherent piece.
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Surviving Remote Teaching during a PandemicOn March 11, 2020, the Governor of New York, Andrew Cuomo, announced SUNY and CUNY Colleges of New York would move to online instruction only, as of March 19, 2020. At the same time, school districts throughout the state were moving their curriculum online, and non-essential businesses were being required to have their workers work at home. The headlines across the state were reminding everyone to “stay home” because of the Covid-19. The news was frightening to some of the Professors, Adjuncts and Teachers all across the state, (especially in K-12). In this paper, I will refer to all folks who teach as ‘Instructors’ or ‘Educators.’ These Instructors, who teach in person, and have never taught an online course, were expressing their concern that their course “could not” be taught on line. My Capstone Project is to create a “Guide” with some ideas to help in this stressful time.
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POLITICAUSE.NET: DEVELOPING A VIRTUAL CROWDSOURCING COMMUNITY TO INCREASE THE ENGAGEMENT OF WOMEN IN POLITICSFor the past 40 years, the continued growth and engagement of women in the political process has created opportunities to increase the influence of the female electorate. Through grassroots political activism, community networks, and online advocacy, women voters have been galvanized to come together collectively to take action to address relevant political issues, but this rising political enthusiasm has not translated into an equal focus on women's issues or equal representation in Congress. This thesis examines the factors that have contributed to the growth and influence of women's political advocacy and explores women's political engagement/activism, traditional vs. online activism, the effectiveness of all-women online networks, and female voter demographics. Based on this research, I developed a virtual crowdsourcing community as a shared space for members to propose and discuss important and timely women's issues including domestic violence, reproductive health, and pay equity and to collaborate to suggest relevant legislation to political leaders. The purpose of this social network is provide a platform for women activists and constituents to connect with others who want to advance the political causes that are relevant to women and to increase the engagement of women in politics to achieve gender equality in local and national government.
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Creating a User-Friendly Mobile Application PrototypeIn today's world users have access to hundreds of thousands of mobile applications at the touch of their fingers. There are over two hundred and fifty million smart phone users out there and that number is growing with over 80% of Americans owning a smartphone. There is nothing more frustrating than trying to use an application and not being sure what to do. Colors or fonts can make things hard to read, too many options to click with no real direction; this will cause frustration for the user and negative feelings towards the application. Making sure that a mobile application is user-friendly is essential to its success, the first time a user opens up the application they need to know exactly what to do and how each action will interact. This project will include a complete sports betting mobile application prototype that covers all the necessary principles of a user-friendly application, along with research to explain why these principles are important. To make a user-friendly application, it is very important to make sure that the user is engaged. This was done by choosing a color scheme that gives a positive emotion, which will bring the user back and continue to use the application. Also, limit what actions the user can do, this can be done with consistency, constraint, and control. Consistency makes sure that users see similarity on how to perform all actions. Constraint limits the actions a user can perform to reduce any errors. Control makes sure that users of all levels have the ability to use the application.
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WRITING FROM THE BORDERLINES: Online Resource for Libraries to Create and Promote Collections by Latinx AuthorsAs of July 1, 2018, the “Hispanic” or “Latino” population of the United States was 18.3 percent of the total United States population, making them the most numerous, officially-recognized ethnic or racial minority in the country. Although the terms Hispanic and Latino are used interchangeably by the United States Census Bureau, they do not refer to the same populations. Hispanic means anyone with Spanish European ancestry, which includes all of the Spanish-speaking countries of Latin America as well as Spain. It does not include Brazil (where Portuguese is spoken) or other territories that were successfully colonized by France, Great Britain, and the Netherlands. Also, Latin America has a long and painful history of Iberian colonialism, and there are large indigenous communities in Latin America with little or no Spanish or Portuguese DNA that would not be considered, nor would they want to be considered, anything other than indigenous. Latino/a is shorthand for latinoamericano and in the United States, refers to anyone living in this country who has ancestry from a Spanish, Portuguese, or French speaking Latin American country. This term therefore excludes persons from areas colonized by the British and Dutch, as well as persons from romance language speaking European countries. The term “Latinx” recently has gained popularity as a gender-neutral way to refer to this Latino/a population. Although Latinx people comprise 18.3 percent of the United States population, they comprise only 6 percent of the persons employed or otherwise engaged in the United States publishing industry. This means that Latinx writers are under-represented in the United States publishing industry and in the number of books that are published. As agents of social change and points of information access, librarians are well-positioned to change this situation by supporting and promoting Latinx authors. The purpose of the accompanying website. (www.writingfromtheborderlines.com) is to provide a guide for libraries wishing to create, increase, or promote collections by Latinx authors. The website has five sections. The first section is an explanation of the term “Latinx”. The second section is a list of Latinx authors organized by the audiences for whom they write. The third section describes grassroots campaigns to increase diversity in literature. The fourth section has an infographic and explanatory text demonstrating the population and publishing industry data. Finally, the fifth section offers ideas on how libraries can promote their diverse collections.
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A Personal Web Portfolio: Creating an Online Presence from Conception to ImplementationApproaching the end of my two-year journey through SUNY Poly’s online IDT program, I felt it was necessary for me to create an artifact showcasing my growth and progression as an Information Designer. Since I completed my degree entirely online (via distance learning), I decided to create a web portfolio representing my work in the program. This paper maps, from concept to execution, my process for creating a personal portfolio website. It includes research and analysis of existing portfolios websites, and it investigates how technology and selected design principles influence a website’s creation. The research presented here culminates with the creation and launch of my own personal portfolio website.
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Creation of a Science, Technology, Engineering, and Mathematics Influencer Repository for High School GirlsWhen utilized strategically, Universal Principles of Design, and more specifically, User Experience Design, can enhance the individualized impact and effectiveness of interactive digital resources. This paper will explore the gender disparity in science, technology, engineering and math STEM education and professions, factors that influence the representation of girls and women the STEM pipeline, and a technology solution that addresses one specific factor for the underrepresentation of females in STEM: the lack of visibility of female role models in these fields. In creating a mobile website prototype for a social media repository of female professionals in STEM, this paper will also examine the impact of social media "influencing" on teenagers, and the ways in which design principles can be implemented to promote an intuitive and highly personalized website experience that allows high school girls to see their own identities and outlooks represented in STEM professions.
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Postmodernism & Punk: Examining a Counterculture’s Significance: The Creation of a Digital ExhibitAs an IDT major, my focus is on graphic design and the visual arts. Examining where we have come in terms of graphic design aesthetics is important to continue to grow as creators. We take inspiration and develop something either similar to what we have learned or something completely new, which we would not know without learning about what past designers have done. Design is essential, it is used in every aspect of life, whether it be acknowledged or not. Without design, we cannot always communicate effectively. We incorporate design into advertising so that people will understand a product or just share information. Graphic Design is not just used for monetary profits though. Design is a way for artists to share their creativity with the world. Each designer has their own style that is unlike any others, just like significant design movements in the art world. The point of art is to establish yourself as different from the rest, so why were movements like postmodernism and punk dismissed when that is exactly what they sought to do? We must share in all forms of the visual arts and not decide what can or cannot be art.
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DEPLOYING CREATIVITY IN SMART CITIES PROJECTThe primary objectives of information design are to develop information artifacts, design interactions with technologies, and enable people to navigate in physical and virtual spaces. The aims are to improve efficiency, enhance productivity, or to solve problems through the knowledge produced by the information products. The goal of this project is to present various avenues through which information design could expand its horizons. In conjunction with this paper, the presentation slides: “Synchronizing Creativity in Smart Cities around the World: The Creative Way of Life,” demonstrate that when combining the literature in English with information design and technological abilities, innovation and creativity can emerge. Institutions such as International Organizations, Standards-setting organizations, research agencies, and the U.S. agenda on innovation are discussed. Internet of Things, Big Data, Cyber-Physical Systems, Smart Cities, and the creative economy under the new name of “Orange Economy” are explored. I conclude with a personal reflection on the journey in producing this project relative to the power of the literature in English, including what “smartness” could mean in the field of information design as well as in humanity.
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Modern Virtual Environments and MuseumsToday, many places and environments are replicated digitally for several different reasons. Some of these popular use-cases include video-games, virtual travel, remote learning, and virtual museums. In some cases, they are purely for entertainment, and in others they are purely for convenience or reaching a wider audience. Digital museums, virtual tours, and even modern video games replicate actual and historical places into “Virtual Worlds” in order to overcome barriers like distance, travel, cost, availability, and even existence. Through studying various literature, case studies, and deployed applications, this project will attempt to understand the history and development of virtual worlds and how we use them today. Using the popular example of Virtual Museums, this paper and the associated project attempt to explore and analyze the value and quality of learning and process involved in the deployment of a virtual world.
