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dc.contributor.authorKennedy, Byron
dc.contributor.authorBedard, Brenden A.
dc.contributor.authorYounge, Mary
dc.contributor.authorTuttle, Deborah
dc.contributor.authorAmmerman, Eric
dc.contributor.authorRicci, John
dc.contributor.authorDoniger, Andrew S.
dc.contributor.authorEscuyer, Vincent E.
dc.contributor.authorMitchell, Kara
dc.contributor.authorNoble-Wang, Judith A.
dc.contributor.authorO'Connell, Heather A.
dc.contributor.authorLanier, William A.
dc.contributor.authorKatz, Linda M.
dc.contributor.authorBetts, Robert F.
dc.contributor.authorMercurio, Mary Gail
dc.contributor.authorScott, Glynis A.
dc.contributor.authorLewis, Matthew A.
dc.contributor.authorGoldgeier, Mark H.
dc.date.accessioned2021-09-07T17:43:02Z
dc.date.available2021-09-07T17:43:02Z
dc.date.issued8/22/2012
dc.identifier.citationThis article was published on August 22, 2012, at NEJM.org. N Engl J Med 2012;367:1020-4. DOI: 10.1056/NEJMoa1205114 Copyright © 2012 Massachusetts Medical Society.
dc.identifier.doihttps://doi.org/10.1056/NEJMoa1205114
dc.identifier.urihttp://hdl.handle.net/20.500.12648/2356
dc.description.abstractBackground In January 2012, on the basis of an initial report from a dermatologist, we began to investigate an outbreak of tattoo-associated Mycobacterium chelonae skin and softtissue infections in Rochester, New York. The main goals were to identify the extent, cause, and form of transmission of the outbreak and to prevent further cases of infection. Methods We analyzed data from structured interviews with the patients, histopathological testing of skin-biopsy specimens, acid-fast bacilli smears, and microbial cultures and antimicrobial susceptibility testing. We also performed DNA sequencing, pulsed-field gel electrophoresis (PFGE), cultures of the ink and ingredients used in the preparation and packaging of the ink, assessment of source water and faucets at tattoo parlors, and investigation of the ink manufacturer. Results Between October and December 2011, a persistent, raised, erythematous rash in the tattoo area developed in 19 persons (13 men and 6 women) within 3 weeks after they received a tattoo from a single artist who used premixed gray ink; the highest occurrence of tattooing and rash onset was in November (accounting for 15 and 12 patients, respectively). The average age of the patients was 35 years (range, 18 to 48). Skin-biopsy specimens, obtained from 17 patients, showed abnormalities in all 17, with M. chelonae isolated from 14 and confirmed by means of DNA sequencing. PFGE analysis showed indistinguishable patterns in 11 clinical isolates and one of three unopened bottles of premixed ink. Eighteen of the 19 patients were treated with appropriate antibiotics, and their condition improved. Conclusions The premixed ink was the common source of infection in this outbreak. These findings led to a recall by the manufacturer.
dc.subjectMycobacterium Chelonae
dc.subjectTattoo
dc.subjectSkin Infection
dc.subjectInk
dc.titleOutbreak of Mycobacterium chelonae Infection Associated with Tattoo Ink
dc.typearticle
dc.source.journaltitleNew England Journal of Medicine
dc.source.volume367
dc.source.issue11
refterms.dateFOA2021-09-07T17:43:02Z
dc.description.institutionSUNY Brockport
dc.source.peerreviewedTRUE
dc.source.statuspublished
dc.description.publicationtitleHealth Science Faculty Publications
dc.contributor.organizationMonroe County Department of Public Health
dc.contributor.organizationThe College at Brockport
dc.languate.isoen_US


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