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dc.contributor.authorBiederman, Joseph
dc.contributor.authorPetty, Carter R.
dc.contributor.authorWilens, Timothy E.
dc.contributor.authorFraire, Maria G.
dc.contributor.authorPurcell, Caitlin A.
dc.contributor.authorMick, Eric
dc.contributor.authorMonuteaux, Michael C.
dc.contributor.authorFaraone, Stephen V.
dc.date.accessioned2021-08-02T17:04:26Z
dc.date.available2021-08-02T17:04:26Z
dc.date.issued2008-01
dc.identifier.issn0002-953X
dc.identifier.eissn1535-7228
dc.identifier.doi10.1176/appi.ajp.2007.07030419
dc.identifier.pii10.1176/appi.ajp.2007.07030419
dc.identifier.urihttp://hdl.handle.net/20.500.12648/2023
dc.description.abstractObjective: A robust and bidirectional comorbidity between attention deficit hyperactivity disorder (ADHD) and psychoactive substance use disorder (alcohol or drug abuse or dependence) has been consistently reported in the extant literature. Method: First-degree relatives from a large group of pediatrically and psychiatrically referred boys with (112 probands, 385 relatives) and without (105 probands, 358 relatives) ADHD were comprehensively assessed by blind raters with structured diagnostic interviews. Familial risk analysis examined the risks in first-degree relatives for ADHD, psychoactive substance use disorder, alcohol dependence, and drug dependence after stratifying probands by the presence and absence of these disorders. Results: ADHD in the proband was consistently associated with a significant risk for ADHD in relatives. Drug dependence in probands increased the risk for drug dependence in relatives irrespective of ADHD status, whereas alcohol dependence in relatives was predicted only by ADHD probands with comorbid alcohol dependence. In addition, ADHD in the proband predicted drug dependence in relatives, and drug dependence in comparison probands increased the risk for ADHD in relatives. Both alcohol dependence and drug dependence bred true in families without evidence for a common risk between these disorders. Conclusions: Patterns of familial risk analysis suggest that the association between ADHD and drug dependence is most consistent with the hypothesis of variable expressivity of a common risk between these disorders, whereas the association between ADHD and alcohol dependence is most consistent with the hypothesis of independent transmission of these disorders. Findings also suggest specificity for the transmission of alcohol and drug dependence.en_US
dc.language.isoenen_US
dc.publisherAmerican Psychiatric Association Publishingen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPsychiatry and Mental healthen_US
dc.titleFamilial Risk Analyses of Attention Deficit Hyperactivity Disorder and Substance Use Disordersen_US
dc.typeArticleen_US
dc.source.journaltitleAmerican Journal of Psychiatryen_US
dc.source.volume165
dc.source.issue1
dc.source.beginpage107
dc.source.endpage115
dc.description.versionAMen_US
refterms.dateFOA2009-01-31T00:00:00Z
dc.description.institutionUpstate Medical Universityen_US
dc.description.departmentPsychiatryen_US
dc.description.degreelevelN/Aen_US


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