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dc.contributor.advisorFaraone, Stephen
dc.contributor.authorYang, Lina
dc.date.accessioned2021-07-19T18:18:28Z
dc.date.available2021-07-19T18:18:28Z
dc.date.issued2014
dc.identifier.urihttp://hdl.handle.net/20.500.12648/1901
dc.description.abstractutism spectrum disorders (ASDs) are a group of neurodevelopmental disorders which begin in childhood and persist into adulthood. They cause lifelong impairments and are associated with substantial burdens to patients, families and society. Genetic studies have implicated the sodium/proton exchanger (NHE) nine gene, SLC9A9, to ASDs and attention-deficit/hyperactivity disorder (ADHD). SLC9A9 encodes, NHE9, a membrane protein of the late recycling endosomes. The recycling endosome plays an important role in synapse development and plasticity by regulating the trafficking of membrane neurotransmitter receptors and transporters. Here we tested the hypothesis thatSLC9A9 knock-out (KO) mice would show ADHD-like and ASD-like traits. Ultrasonic vocalization recording showed that SLC9A9 KO mice emitted fewer calls and had shorter call durations, which suggest communication impairment. SLC9A9 KO mice lacked a preference for social novelty, but did not show deficits in social approach; SLC9A9 KO mice spent more time self-grooming, an indicator for restricted and repetitive behavior. We did not observe hyperactivity or other behavior impairments which are commonly comorbid with ASDs in human, such as anxiety-like behavior. Our study is the first animal behavior study that links SLC9A9 to ASDs. By eliminating NHE9 activity, it provides strong evidence that lack of SLC9A9 leads to ASD-like behaviors in mice and provides the field with a new mouse model of ASDs.en_US
dc.language.isoenen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAUTISM SPECTRUM DISORDERen_US
dc.subjectTRAITSen_US
dc.subjectSLC9A9en_US
dc.subjectKNOCK‐OUTen_US
dc.subjectMICEen_US
dc.titleAutism spectrum disorder traits in SLC9A9 knock-out miceen_US
dc.typeThesisen_US
dc.description.versionNAen_US
refterms.dateFOA2021-07-19T18:18:29Z
dc.description.institutionUpstate Medical Universityen_US
dc.description.departmentNeuroscience and Physiologyen_US
dc.description.degreelevelMSen_US
dc.identifier.oclc57564789


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