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dc.contributor.authorMick, Eric
dc.contributor.authorKim, Jang Woo
dc.contributor.authorBiederman, Joseph
dc.contributor.authorWozniak, Janet
dc.contributor.authorWilens, Timothy
dc.contributor.authorSpencer, Thomas
dc.contributor.authorSmoller, Jordan W.
dc.contributor.authorFaraone, Stephen V.
dc.date.accessioned2021-07-19T17:23:32Z
dc.date.available2021-07-19T17:23:32Z
dc.date.issued2008-10-05
dc.identifier.issn1552-4841
dc.identifier.eissn1552-485X
dc.identifier.doi10.1002/ajmg.b.30745
dc.identifier.urihttp://hdl.handle.net/20.500.12648/1898
dc.description.abstractThedopaminetransportergene(SLC6A3) isacompelling candidate for pediatric bipolar disorder because (a) it has been associated with ADHD, (b) bipolar comorbidity with ADHD has been hypothesized to be an etiologically distinct familial subtype (c) blockade of the dopamine transporter with psychostimulants can induce mania in susceptible individualsand(d) previous studies have implicated the gene in bipolar disorder in adults. We conducted a family-based association study of SLC6A3 in 170 affected offspring trios defined by a child (12.9 5.3 years of age)with DSM-IV Bipolar-I disorder. Twenty-eight tag SNPs were chosen from the CEU (European) population of the International HapMap project (www.hapmap.org). Results indicated nominally positive association for 4 SNPs (rs40184, rs11133767, rs3776512, and rs464049), but only rs40184 survived correction formultiple statistical comparisons (P¼0.038). This is the first examination of the association with SLC6A3 and bipolar disorder in children and, like previous findings in adults with bipolar disorder, we found evidence of association with SNPs in the 30 region of the gene. These data provide suggestive evidence supporting a role for SLC6A3 in the etiology of pediatric bipolar disorder.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://doi.wiley.com/10.1002/tdm_license_1.1
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCellular and Molecular Neuroscienceen_US
dc.subjectPsychiatry and Mental healthen_US
dc.subjectGenetics(clinical)en_US
dc.subjectbipolar disorder; dopamine transporter; pediatricen_US
dc.titleFamily based association study of pediatric bipolar disorder and the dopamine transporter gene (SLC6A3)en_US
dc.typeArticleen_US
dc.source.journaltitleAmerican Journal of Medical Genetics Part B: Neuropsychiatric Geneticsen_US
dc.source.volume147B
dc.source.issue7
dc.source.beginpage1182
dc.source.endpage1185
dc.description.versionAMen_US
refterms.dateFOA2009-10-05T00:00:00Z
dc.description.institutionUpstate Medical Universityen_US
dc.description.departmentPsychiatryen_US
dc.description.degreelevelN/Aen_US


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