Show simple item record

dc.contributor.advisorYoungentob, Steven
dc.contributor.authorMANTELLA, NICOLE
dc.date.accessioned2021-07-15T17:19:21Z
dc.date.available2021-07-15T17:19:21Z
dc.date.issued2015
dc.identifier.urihttp://hdl.handle.net/20.500.12648/1861
dc.description.abstractHuman studies demonstrate a predictive association between gestational exposure to alcohol or nicotine and the probabilityoflater nicotine dependence.The flavor qualitiesof both drugsare known to influencetheir earlyacceptance and they share the perceptual attributesof an aversive odor, bitter taste and oral irritation.This dissertationexamined whether there are chemosensory-­‐related consequences offetal: (1) alcohol exposurethat contribute toenhanced nicotine acceptance; or (2)nicotine exposure that also enhances acceptance. The study rationale was drivenby overlappingliteraturesrelated to: (1) the relationship between gestational exposurewith chemosensory stimuli and their postnatal acceptance; (2) lessons learned from prenatal alcohol exposure and its postnatal consequences; and (3) perceptual commonalities between the flavor of alcohol and nicotine.Alcohol studies: rats were alcohol-­‐exposed during gestationvia the dams’ liquid diet. Control damsreceived ad libaccessto an iso-­‐caloric, iso-­‐nutritive diet. Nicotine studies: dams’ were implanted with a mini-­‐osmotic pump containing nicotine.Control animals received either vehicle only or no pump. Behaviorally, we found that fetal alcohol exposed adolescent rats showed anenhanced nicotine odoren_US
dc.language.isoen_USen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectChemosensoryen_US
dc.subjectConsequencesen_US
dc.subjectFetal Ethanolen_US
dc.subjectFetal Nicotine Exposureen_US
dc.subjectContributionen_US
dc.subjectPostnatal Nicotine Acceptanceen_US
dc.titleThe Chemosensory-­Related Consequences of Fetal Ethanol or Fetal Nicotine Exposure: Their Contribution to Postnatal Nicotine Acceptanceen_US
dc.typeDissertationen_US
dc.description.versionNAen_US
refterms.dateFOA2021-07-15T17:19:22Z
dc.description.institutionUpstate Medical Universityen_US
dc.description.departmentNeuroscienceen_US
dc.description.degreelevelPhDen_US
dc.identifier.oclc1034990626


Files in this item

Thumbnail
Name:
Mantella.pdf
Size:
5.811Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International