Show simple item record

dc.contributor.authorLi, Jun
dc.contributor.authorWang, Yufeng
dc.contributor.authorHu, Songnian
dc.contributor.authorZhou, Rulun
dc.contributor.authorYu, Xiaomin
dc.contributor.authorWang, Bing
dc.contributor.authorGuan, Lili
dc.contributor.authorYang, Li
dc.contributor.authorZhang, Feng
dc.contributor.authorFaraone, Stephen V.
dc.date.accessioned2021-07-14T16:24:04Z
dc.date.available2021-07-14T16:24:04Z
dc.date.issued2008
dc.identifier.issn1552-4841
dc.identifier.eissn1552-485X
dc.identifier.doi10.1002/ajmg.b.30606
dc.identifier.urihttp://hdl.handle.net/20.500.12648/1843
dc.description.abstractAttention deficit hyperactivity disorder (ADHD) is a common neuropsychiatric condition with strong genetic basis. Recent work in China indicated that ADHD may be linked to Xp1–2 in the Han Chinese population. The gene encoding monoamine oxidase B (MAOB), the main enzyme degrading dopamine in the human brain, is located in this region. The current study sequenced the exons and the 50 and 30 flanking regions of theMAOBgene and found four common variants including 2276C>T and 2327C>T in exon 15, rs1799836 in intron 13 and rs1040399 in 30-UTR. We assessed the association of these variants with ADHD in 548 trios collected from 468 males and 80 females probands. TDT analysis showed that alleles of each polymorphism were preferentially transmitted to probands (rs1799836, P¼3.28E-15; rs1040399, P¼1.87E-6; 2276T>C or 2327T>C, P¼2.20E-6) and haplotype-based TDT analyses also found distorted transmission. In conclusion, this study provides the strongest evidence for the involvement of MAOB gene in the etiology of ADHD to date, at least in Han Chinese population.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://doi.wiley.com/10.1002/tdm_license_1.1
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCellular and Molecular Neuroscienceen_US
dc.subjectPsychiatry and Mental healthen_US
dc.subjectGenetics(clinical)en_US
dc.subjectgene; ADHD; X chromosome; sequence; monoamine oxidase Ben_US
dc.titleThe monoamine oxidase B gene exhibits significant association to ADHDen_US
dc.typeArticleen_US
dc.source.journaltitleAmerican Journal of Medical Genetics Part B: Neuropsychiatric Geneticsen_US
dc.source.volume147B
dc.source.issue3
dc.source.beginpage370
dc.source.endpage374
dc.description.versionAMen_US
refterms.dateFOA2008-07-12T00:00:00Z
dc.description.institutionUpstate Medical Universityen_US
dc.description.departmentPsychiatryen_US
dc.description.degreelevelN/Aen_US


Files in this item

Thumbnail
Name:
Faraone 2008 The_monoamine_oxi ...
Size:
233.4Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record