Genome-wide association study of response to methylphenidate in 187 children with attention-deficit/hyperactivity disorder
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Keyword
Cellular and Molecular NeurosciencePsychiatry and Mental health
Genetics(clinical)
ADHD; methylphenidate; genomewide association study; pharmacogenomic
Journal title
American Journal of Medical Genetics Part B: Neuropsychiatric GeneticsDate Published
2008-12-05Publication Volume
147BPublication Issue
8Publication Begin page
1412Publication End page
1418
Metadata
Show full item recordAbstract
We conducted a genome-wide association study of symptom response in an open-label study of a methylphenidate transdermal system (MTS). All DNA extraction and genotyping was conducted at SUNY Upstate Medical University using the Affymetrix Genome-Wide Human SNP Array 6.0. All quality control and association analyses were conducted using the software package PLINK. After data cleaning and quality control, there were 187 subjects (72% (N¼135) male) with mean age 9.2 2.0 years and 319,722 SNPs available for analysis. The most statistically significant association (rs9627183 andrs11134178;P¼3 10 6) fell short of the threshold for a genome-wide significant association. The most intriguing association amongsuggestivefindings(rs3792452;P¼2.6 10 5) was with the metabotropic glutamate receptor 7 gene (GRM7) as it is expressed in brain structures also previously associated with ADHD. Among the 102 available SNPs covering previously studied candidate genes, two SNPs within the norepinephrine transporter gene (NET, SLC6A2) were significant at P 1 10 2. These results should be considered preliminary until replicated in larger adequately powered, controlled samples but do suggest that noradrenergic and possibly glutaminergic genes may be involved with response to methylphenidate.DOI
10.1002/ajmg.b.30865ae974a485f413a2113503eed53cd6c53
10.1002/ajmg.b.30865
Scopus Count
The following license files are associated with this item:
- Creative Commons